Psychopharmacological Treatment and Psychosurgery

1982 ◽  
pp. 241-249 ◽  
Author(s):  
Paul M. G. Emmelkamp
Keyword(s):  
Psychopharmacological Treatment

Metabolic abnormalities in patients with chronic psychiatric disorders receiving long-term psychopharmacological treatment

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
B Reisinger ◽  
E Mueller ◽  
B Kropp-Hartmann ◽  
D Wölflick ◽  
C Zimmerer ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Metabolic Abnormalities ◽  
Psychopharmacological Treatment

Trombodynamics Method in the Assessment of Coagulation Parameters in Psychopharmacotherapy of Endogenous Mental Disorders

Psychiatry ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 16-25
Author(s):  
N. S. Karpova ◽  
O. S. Brusov ◽  
I. V. Oleichik ◽  
M. I. Faktor ◽  
N. S. Levchenko ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Response To Therapy ◽  
Procoagulant Activity ◽  
Coagulation Activity ◽  
Continuous Type ◽  
Chronic Neuroinflammation ◽  
Psychopharmacological Treatment ◽  
Before And After ◽  
First Time ◽  
Schizotypal Disorder

Background: currently, it has been proven that the pathogenesis of endogenous mental disorders is associated with the process of neuroinflammation in the brain of patients. It is also known that chronic neuroinflammation, accompanied by a violation the permeability of the blood-brain barrier. It is accompanied by the activation of platelets that generate procoagulant microparticles, which leads to a disturbance of the hemostasis system, causing an increase in blood clotting in patients. Objective: to investigate the dynamics of procoagulant activity of blood in patients with endogenous mental disorders before and after psychopharmacotherapy.Patients and methods: the study included 185 patients aged 16 to 64 years with the following mental disorders: schizophrenia with attack-like/attack-progressive/continuous type of course (F20.00–2), affective disease (F31.1–5; F32.0–3; F33.0–3), schizotypal disorder with affective fluctuations (F21.3–4). The thrombodynamic test (TD) was performed on T-2 Trombodynamis device according to the manufacturer’s instructions (Hemacore LLC, Moscow, Russia). All patients received standard pharmacotherapy according to their condition.Results: a significant decrease of procoagulant activity of spontaneous clots in the patients’ blood after psychopharmacological treatment is observed. Our data on the positive dynamics of changes in the values of TD test’s indicators in most of the examined patients suggest that a decrease in the coagulation activity of the patients’ blood as a result of treatment may be associated with the anti- inflammatory effect of antipsychotics and antidepressants.Conclusion: for the first time, it was shown that there is a positive dynamic in changing the values of the main parameters of the TD test in most patients with endogenous mental diseases. The results of TD tests can be the basis for monitoring the response to therapy.

scholarly journals Clinical Pharmacology of Hyperammonemia by Sodium Valproate and Carbamazepine in People Living with HIV

CNS Spectrums ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 143-143
Author(s):  
Martin J. Mazzoglio y Nabar ◽  
Santiago Muñoz ◽  
Milagros Muñiz ◽  
Alexis Mejías ◽  
Christian Montivero ◽  
...  
Keyword(s):  
Valproic Acid ◽  
People Living With Hiv ◽  
Preventive Control ◽  
Decompensated Liver Disease ◽  
Viral Loads ◽  
Daily Life Activities ◽  
Psychopharmacological Treatment ◽  
Immunodeficiency Virus ◽  
Cirrhotic Patients ◽  
Living With Hiv

AbstractIntroductionHyperammonaemia (HA) is observed in decompensated liver disease. The picture of hyperammonemic encephalopathy in non-cirrhotic patients was reported mostly associated with valproic acid. There are few reports of hyperammonemia in people living with human immunodeficiency virus (PLHIV) and they are associated with other comorbidities and few with antiretrovirals (HAART), but not as adverse drug reactions associated with psychotropic drugs associated with the virus.ObjectiveReport of cases of PLHIV in HARRT with hyperammonemia, its clinical impact and ammonium levels.Materials and MethodsWe report 67 PLHIV in treatment with HAART, negative viral loads, psychopharmacological treatment with valproic acid (n=45) or carbamazepine (n=22). Exclusion criteria were = HCV, HBV and alcohol consumption disorder (current or recent history) and decompensated liver pathology. We apply scales to evaluate side effects (UKU), subjective adherence (DAI), daily life activities (Barthel Index), liver severity (Child-Pugh Classification) and degrees of hepatic encephalopathy (West Haven Scale). The ethical-legal requirements were met. Results: 26.86% presented hyperammonemia, among which 38.88% was symptomatic. The clinical presentation was heterogeneous with a higher prevalence of gastrointestinal and cognitive alterations; the most severe cases presented alterations of the sensorium and 1 case of convulsions. We recorded a greater symptomatic severity with carbamazepine (average ammonia =104.4 pmol/L), but a higher prevalence of non-symptomatic hyperammonemia with valproic acid (62.3 pmol/L). The time of onset of symptoms was lower with carbamazepine, but the time until its decrease was higher with valproic acid.ConclusionsWe observed a higher prevalence of hyperammonemia and associated symptomatology in PLHIV with HAART medicated with carbamazepine. The significant percentage of this adverse drug reaction suggests a biochemical, perhaps preventive, control.

scholarly journals Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis

Medicina ◽  
2020 ◽  
Vol 56 (2) ◽  
pp. 67
Author(s):  
Adam Włodarczyk ◽  
Wiesław Jerzy Cubała
Keyword(s):  
Bipolar Depression ◽  
Myocardial Infarct ◽  
The Elderly ◽  
Nmda Receptor Antagonist ◽  
Treatment Resistant ◽  
Psychopharmacological Treatment ◽  
Somatic Comorbidities ◽  
Single Use ◽  
Diabetes And Obesity ◽  
Depressive Patients

The current psychopharmacological treatment approaches for major depression focus on monoaminergic interventions, which are ineffective in a large proportion of patients. Globally, treatment-resistant bipolar depression (TRBD) affects up to 33% of depressive patients receiving treatment. Certain needs are still unmet and require new approaches. Many studies are in favor of treatments with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, even in single use, whose effects emerge in minutes to hours post administration. However, little data are available on ketamine performance in TRBD patients with somatic comorbidities, including highly prevalent ones, i.e., cardiovascular disease (heart failure, hypertension, post-myocardial infarct, arrhythmias, etc.) diabetes, and obesity, and depression-associated comorbidities such as stroke, epilepsy, as well as in the elderly population. The literature shows that treatment with ketamine is efficacious and safe, and the majority of adverse drug reactions are mild and tend to mostly disappear within 30 min to 2 h of ketamine administration.

I38 A clinical based synopsis of available psychopharmacological treatment in huntington’s disease

2016 ◽  
Vol 87 (Suppl 1) ◽  
pp. A72.1-A72
Author(s):  
Elisabetta Caletti ◽  
Elisa Zugno ◽  
Andrea Botturi ◽  
Cecilia Prunas ◽  
Michela Cigliobianco ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Psychopharmacological Treatment

P-2-38 Psychopharmacological treatment of anorexia nervosa

1995 ◽  
Vol 5 (3) ◽  
pp. 287
Author(s):  
A. Cebollada ◽  
A. Chinchilla ◽  
M. Vega ◽  
J.J. Padín ◽  
J.M. Montes ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Psychopharmacological Treatment

scholarly journals Predictors and Moderators of Quality of Life Among College Students With ADHD

2017 ◽  
Vol 23 (14) ◽  
pp. 1736-1745 ◽  
Author(s):  
Trevor D. Pinho ◽  
Patricia H. Manz ◽  
George J. DuPaul ◽  
Arthur D. Anastopoulos ◽  
Lisa L Weyandt
Keyword(s):  
Quality Of Life ◽  
College Students ◽  
Drug Use ◽  
Psychosocial Treatment ◽  
Psychopharmacological Treatment ◽  
Study Results ◽  
Students With Adhd ◽  
The Relationship ◽  
Total Impact

Objective: The current study examines (a) whether ADHD among college students is associated with differences in perceptions of quality of life (QoL); (b) the moderating roles of comorbidity, drug use, psychopharmacological treatment, and psychosocial treatment; and (c) the total impact of these variables on QoL. Method: Participants were college students with and without ADHD ( N = 372) in a longitudinal study. Results: College students with ADHD were more likely to assert negative global QoL evaluations relative to non-ADHD peers. The relationship between ADHD and QoL was not altered as a function of medication treatment, comorbid psychopathology, psychosocial treatment, or drug use. Conclusion: College students with ADHD behave similarly to other adults with ADHD in that they make lower subjective global evaluations of their QoL relative to their non-ADHD agemates. Other factors associated with ADHD and QoL do not appear to moderate this relationship.

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