The Effect of Ingestion of Megadoses of Ascorbic Acid on Urinary Oxalate Excretion in Normal Subjects and Stone Formers

1985 ◽  
pp. 225-228 ◽  
Author(s):  
A. K. Pendse ◽  
A. K. Purchit ◽  
R. Ghosh ◽  
A. Goyal ◽  
P. P. Singh
Keyword(s):  
Ascorbic Acid ◽  
Normal Subjects ◽  
Urinary Oxalate ◽  
Oxalate Excretion ◽  
Stone Formers ◽  
Urinary Oxalate Excretion

scholarly journals The Variability and Dietary Dependence of Urinary Oxalate Excretion in Recurrent Calcium Stone Formers

1987 ◽  
Vol 24 (4) ◽  
pp. 385-390 ◽  
Author(s):  
J M Brown ◽  
G Stratmann ◽  
D M Cowley ◽  
B M Mottram ◽  
A H Chalmers
Keyword(s):  
Calcium Intake ◽  
Normal Subjects ◽  
Urinary Calcium ◽  
Stone Disease ◽  
Calcium Excretion ◽  
Urinary Oxalate ◽  
Calcium Stone ◽  
Oxalate Excretion ◽  
Stone Formers ◽  
Urinary Oxalate Excretion

Twenty-two recurrent calcium stone formers had 24-h urinary oxalate excretions on their home diets which were significantly greater than those of 30 normal subjects (0·48±0·23 mmol/d; mean±SD compared with 0·31±0·11; P<0·01). The stone formers also demonstrated marked day to day variability in oxalate excretion indicating that a single normal urinary oxalate measurement did not exclude significant hyperoxaluria at other times. On a hospital diet containing 1000 mg calcium per day, urinary oxalate excretion fell significantly from 0·48±0·23 mmol/d to 0·32±0·12; P<0·01. As the urinary calcium excretion in and out of hospital was similar, it seems unlikely that low calcium intake at home was responsible for the hyperoxaluria. All patients had recurrent symptomatic stone disease and had been advised to avoid foods rich in oxalate. Whilst poor compliance is a possible explanation for the variability in oxalate excretion, we believe it is more likely that there is an inadvertent intake of oxalogenic precursors in their diet. As normal subjects do not demonstrate hyperoxaluria on similar home diets, stone formers may have a metabolic defect in the handling of these precursors.

Effect of High-Calcium Diet on Urinary Oxalate Excretion in Urinary Stone Formers

1988 ◽  
Vol 15 (3-4) ◽  
pp. 264-270 ◽  
Author(s):  
Teruhiro Nakada ◽  
Isoji Sasagawa ◽  
Hidekatsu Furuta ◽  
Takashi Katayama ◽  
Jun Shimazaki
Keyword(s):  
Urinary Stone ◽  
Urinary Oxalate ◽  
Oxalate Excretion ◽  
Calcium Diet ◽  
Stone Formers ◽  
High Calcium ◽  
High Calcium Diet ◽  
Urinary Oxalate Excretion

scholarly journals Association of urinary sex steroid hormones with urinary calcium, oxalate and citrate excretion in kidney stone formers

2020 ◽  
Author(s):  
Daniel G Fuster ◽  
Gaétan A Morard ◽  
Lisa Schneider ◽  
Cedric Mattmann ◽  
David Lüthi ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Urinary Calcium ◽  
Sex Hormone ◽  
Urinary Oxalate ◽  
Oxalate Excretion ◽  
Stone Formers ◽  
17Β Estradiol ◽  
Urinary Citrate ◽  
Urinary Oxalate Excretion

Abstract Background Sex-specific differences in nephrolithiasis with respect to both distribution of prevalence and stone composition are widely described and may be influenced by sex hormones. Methods We conducted a cross-sectional analysis of the relationship between 24-hour urinary sex hormone metabolites measured by gas chromatography–mass spectrometry with urinary calcium, oxalate and citrate excretion in a cohort of 628 kidney stone formers from a tertiary care hospital in Switzerland, taking demographic characteristics, kidney function and dietary factors into account. Results We observed a positive association of urinary calcium with urinary testosterone and 17β-estradiol. Positive associations of urinary calcium with dehydroepiandrosterone, 5α-DH-testosterone, etiocholanolone, androsterone, and estriol were modified by net gastrointestinal alkali absorption or urinary sulfate excretion. As the only sex hormone, dehydroepiandrosterone was inversely associated with urinary oxalate excretion in adjusted analyses. Urinary citrate correlated positively with urinary testosterone. Associations of urinary citrate with urinary androsterone, 17β-estradiol and estriol were modified by urinary sulfate or sodium, or by sex. Conclusions Urinary androgens and estrogens are significantly associated with urinary calcium and citrate excretion, and associations are in part modified by diet. Our data furthermore reveal dehydroepiandrosterone as a novel factor associated with urinary oxalate excretion in humans.

Urinary oxalate excretion after large intakes of ascorbic acid in man

1981 ◽  
Vol 34 (3) ◽  
pp. 305-311 ◽  
Author(s):  
K H Schmidt ◽  
V Hagmaier ◽  
D H Hornig ◽  
J P Vuilleumier ◽  
G Rutishauser
Keyword(s):  
Ascorbic Acid ◽  
Urinary Oxalate ◽  
Oxalate Excretion ◽  
Urinary Oxalate Excretion

scholarly journals COLON OXALATE-DEGRADING BACTERIA COLONIZATION IN PATIENTS WITH RECURRENT PYELONEPHRITIS AND ITS RELATIONSHIP WITH ADMINISTRATION OF ANTIBIOTICS (PILOT STUDY)

2016 ◽  
pp. 28-31
Author(s):  
N. Dzyubenko ◽  
N. Stashevska ◽  
G. Tolstanova ◽  
T. Sergiychuk ◽  
I. Akulenko ◽  
...  
Keyword(s):  
Inverse Correlation ◽  
Culture Method ◽  
Cross Sectional Study ◽  
Sodium Oxalate ◽  
Urinary Oxalate ◽  
Cross Sectional ◽  
Oxalate Excretion ◽  
Stone Formers ◽  
Degrading Bacteria ◽  
Urinary Oxalate Excretion

Antibiotic therapy and long-term antibiotic prophylaxis affect the normal flora of the gastrointestinal tract in the patients with recurrent pyelonephritis. It may disturb the balance in oxalate-degrading bacteria in colon and induce hyperoxaluria. The aim of this study was to investigate the level of colon oxalate-degrading bacteria colonization inpatients with recurrentpyelonephritis and its association with administration ofantibiotics. Patients and methods. The pilot observational cross-sectional study, involving 12 patients with uncomplicated recurrent pyelonephritis, non-stone formers. Oxalate-degrading bacteria in feces were identified by bacteriological culture method in the sodium oxalate reach medium. Results. Oxalate-degrading bacteria were detected in feces of 6 (50%) surveyed patients. The number of oxalatedegrading bacteria ranged from 2,0 to 7,0 lg CFU/g in feces and depended on the time after the last administration of antibiotics (F = 4,6; P = 0.05). The levels of oxalate-degrading bacteria colonization and urinary oxalate excretion in surveyed women had a moderate inverse correlation (p =-0,6;P = 0.03). Conclusions. The significantly higher urinary oxalate excretion in women non stone-formers with recurrent pyelonephritis may be associated with the application of antibiotics and a subsequent decolonization of oxalate-degrading bfcteria:     must befurther confirmed in ranaomizea study.

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