Genetic Alterations During Carcinogenesis in Rodents: Implications for Cancer Risk Assessment

1990 ◽  
pp. 49-68
Author(s):  
Roger W. Wiseman
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Genetic Alterations ◽  
Cancer Risk Assessment

Molecular Genetics of Cancer

2012 ◽  
Author(s):  
Leif W. Ellisen
Keyword(s):  
Risk Assessment ◽  
Tumor Suppressor ◽  
Environmental Factors ◽  
Cancer Risk ◽  
Tumor Progression ◽  
Cancer Genomics ◽  
Precancerous Lesions ◽  
Expression Profiles ◽  
Genetic Alterations ◽  
Cancer Risk Assessment

The uncontrolled clonal expansion of a cell, which often leads to invasion of surrounding tissues and metastatic spread, produces cancer. A clear histologic and molecular genetic evolution from precancerous lesions to frankly malignant and invasive cancer has been defined for some tumors (e.g., colon and bladder cancers). In rare cases, mutations may occur and be passed on in the germline, resulting in genetic predisposition to cancer (i.e., familial cancer syndromes). Environmental factors are also thought to contribute to the development of cancer. Interactions between environmental factors and subtle germline genetic variations that distinguish individuals may in some cases constitute an important determinant of cancer risk within the general population. Finally, viral infection has been linked to the development of specific cancers. Oncogenes and proto-oncogenes, and germline genetic analysis and cancer risk assessment are covered. Also discussed are genetic alterations and abnormalities, tumor suppressor genes, tumor progression, genetic mechanisms of treatment sensitivity and resistance, and emerging trends in cancer genomics and risk assessment. Figures illustrate activation of proto-oncogenes, the Knudsen two-hit model of tumor initiation, allelic losses in tumors, the retinoblastoma gene (RB1) cell cycle pathway, the p53 cellular stress and DNA damage response pathway, microsatellite instability and DNA mismatch repair, multiple oncogenes and tumor suppressors, tumor progression, cellular senescence and telomerase activation, tumor angiogenesis, chemotherapy drug resistance, targeting of oncogenic proteins by imatinib mesylate, analysis of expression profiles using high-density microarrays, and the spectrum of risk alleles for breast cancer predisposition. Tables outline oncogene and tumor suppressor gene mutations. This chapter contains 119 references.

Risk assessment of ethyl carbamate in alcoholic beverages in Korea using the margin of exposure approach and cancer risk assessment

Food Control ◽  
2021 ◽  
Vol 124 ◽  
pp. 107867
Author(s):  
Sunghyeon Jung ◽  
Seungmin Kim ◽  
Inhwan Kim ◽  
Myung-Sub Chung ◽  
BoKyung Moon ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Ethyl Carbamate ◽  
Alcoholic Beverages ◽  
Cancer Risk Assessment ◽  
Margin Of Exposure

scholarly journals Towards radiologist-level cancer risk assessment in CT lung screening using deep learning

2021 ◽  
pp. 101883
Author(s):  
Stojan Trajanovski ◽  
Dimitrios Mavroeidis ◽  
Christine Leon Swisher ◽  
Binyam Gebrekidan Gebre ◽  
Bastiaan S. Veeling ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Deep Learning ◽  
Cancer Risk ◽  
Cancer Risk Assessment ◽  
Lung Screening

scholarly journals Associations of sociodemographic and clinical factors with gastrointestinal cancer risk assessment appointment completion

2020 ◽  
Vol 29 (4) ◽  
pp. 616-624
Author(s):  
Jessica E. Ebrahimzadeh ◽  
Jessica M. Long ◽  
Louise Wang ◽  
John T. Nathanson ◽  
Shazia Mehmood Siddique ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Gastrointestinal Cancer ◽  
Cancer Risk Assessment ◽  
Clinical Factors
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