Beta-Endorphin in Peripheral Blood Mononuclear Cells: Effect of Aging and Pharmacological Treatments

1994 ◽  
pp. 339-348 ◽  
Author(s):  
Paola Sacerdote ◽  
Emilio Clementi ◽  
Barbara Manfredi ◽  
Alberto E. Panerai
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Pharmacological Treatments ◽  
Peripheral Blood Mononuclear ◽  
Beta Endorphin ◽  
Blood Mononuclear Cells

Age-Related Changes of Beta-Endorphin and Cholecystokinin in Peripheral Blood Mononuclear Cells

1991 ◽  
Vol 621 (1 Physiological) ◽  
pp. 174-178 ◽  
Author(s):  
ALBERTO E. PANERAI ◽  
BARBARA MANFREDI ◽  
LUISA LOCATELLI ◽  
FRANCESCA RUBBOLI ◽  
PAOLA SACERDOTE
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Beta Endorphin ◽  
Age Related ◽  
Blood Mononuclear Cells ◽  
Age Related Changes

Beta-Endorphin Levels are Reduced in Peripheral Blood Mononuclear Cells of Cluster Headache Patients

Cephalalgia ◽  
1993 ◽  
Vol 13 (6) ◽  
pp. 413-416 ◽  
Author(s):  
M Leone ◽  
P Sacerdote ◽  
D D'Amico ◽  
AE Panerai ◽  
G Bussone
Keyword(s):  
Cerebrospinal Fluid ◽  
Cluster Headache ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Healthy Controls ◽  
Peripheral Blood Mononuclear ◽  
Beta Endorphin ◽  
Blood Mononuclear Cells ◽  
Headache Patients

Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p < 0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.

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