Leukocyte Integrins

1993 ◽  
pp. 307-333 ◽  
Author(s):  
Ian Dransfield
Keyword(s):  
Leukocyte Integrins

scholarly journals Leukocyte–Endothelial Adhesion Mechanisms in Epilepsy: Cheers and Jeers

2009 ◽  
Vol 9 (4) ◽  
pp. 118-121 ◽  
Author(s):  
Annamaria Vezzani ◽  
Damir Janigro
Keyword(s):  
Neuronal Excitability ◽  
World Population ◽  
Brain Vessels ◽  
Acute Seizures ◽  
Leukocyte Integrins ◽  
Acute Seizure ◽  
Elevated Expression ◽  
Vascular Adhesion ◽  
Spontaneous Recurrent Seizures ◽  
Blocking Antibodies

A Role for Leukocyte-Endothelial Adhesion Mechanisms in Epilepsy. Fabene PF, Navarro MG, Martinello M, Rossi B, Merigo F, Ottoboni L, Bach S, Angiari S, Benati D, Chakir A, Zanetti L, Schio F, Osculati A, Marzola P, Nicolato E, Homeister JW, Xia L, Lowe JB, McEver RP, Osculati F, Sbarbati A, Butcher EC, Constantin G. Nat Med 2008;14(12):1377–1383. The mechanisms involved in the pathogenesis of epilepsy, a chronic neurological disorder that affects approximately one percent of the world population, are not well understood1,2,3. Using a mouse model of epilepsy, we show that seizures induce elevated expression of vascular cell adhesion molecules and enhanced leukocyte rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1 (PSGL-1, encoded by Selplg) and leukocyte integrins41 and L2. Inhibition of leukocyte-vascular interactions, either with blocking antibodies or by genetically interfering with PSGL-1 function in mice, markedly reduced seizures. Treatment with blocking antibodies after acute seizures prevented the development of epilepsy. Neutrophil depletion also inhibited acute seizure induction and chronic spontaneous recurrent seizures. Blood-brain barrier (BBB) leakage, which is known to enhance neuronal excitability, was induced by acute seizure activity but was prevented by blockade of leukocyte-vascular adhesion, suggesting a pathogenetic link between leukocyte-vascular interactions, BBB damage and seizure generation. Consistent with the potential leukocyte involvement in epilepsy in humans, leukocytes were more abundant in brains of individuals with epilepsy than in controls. Our results suggest leukocyte-endothelial interaction as a potential target for the prevention and treatment of epilepsy.

The gene organization of the human β7 subunit, the common β subunit of the leukocyte integrins HML-1 and LPAM-1

1992 ◽  
Vol 4 (9) ◽  
pp. 1031-1040 ◽  
Author(s):  
Wei-Meng Jiang ◽  
David Jenkins ◽  
Qian Yuan ◽  
Euphemia Leung ◽  
K. H. Andy Choo ◽  
...  
Keyword(s):  
Gene Organization ◽  
Β Subunit ◽  
Leukocyte Integrins ◽  
The Common

Regulation of leukocyte integrins

1992 ◽  
pp. 183-187
Author(s):  
S. D. Wright ◽  
A. Hermanowski-Vosatka ◽  
J. A. G. Van Strijp ◽  
P. A. Detmers
Keyword(s):  
Leukocyte Integrins

Leukocyte Integrins

Integrins ◽  
1994 ◽  
pp. 163-194 ◽  
Author(s):  
Mariano J. Elices
Keyword(s):  
Leukocyte Integrins

The mouse β7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290

1993 ◽  
Vol 5 (5) ◽  
pp. 551-558 ◽  
Author(s):  
Euphemia Leung ◽  
Paul E. Mead ◽  
Qian Yuan ◽  
Wei-Meng Jiang ◽  
James D. Watson ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Gene Promoter ◽  
Leukocyte Integrins ◽  
Integrin Gene

Chapter 4 Activation of Leukocyte Integrins

2009 ◽  
pp. 115-132
Author(s):  
Eun Jeong Park ◽  
Motomu Shimaoka
Keyword(s):  
Leukocyte Integrins

scholarly journals Biology and structure of leukocyte β2 integrins and their role in inflammation

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2433 ◽  
Author(s):  
M. Amin Arnaout
Keyword(s):  
Immune Responses ◽  
Host Defense ◽  
Large Family ◽  
Structural Basis ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Leukocyte Integrins ◽  
And Function ◽  
Integrin Family ◽  
Β2 Integrins

Integrins comprise a large family of αβ heterodimeric cell adhesion receptors that are expressed on all cells except red blood cells and that play essential roles in the regulation of cell growth and function. The leukocyte integrins, which include members of the β1, β2, β3, and β7integrin family, are critical for innate and adaptive immune responses but also can contribute to many inflammatory and autoimmune diseases when dysregulated. This review focuses on the β2integrins, the principal integrins expressed on leukocytes. We review their discovery and role in host defense, the structural basis for their ligand recognition and activation, and their potential as therapeutic targets.

scholarly journals The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 ◽  
Vol 171 (5) ◽  
pp. 1753-1771 ◽  
Author(s):  
J P Metlay ◽  
M D Witmer-Pack ◽  
R Agger ◽  
M T Crowley ◽  
D Lawless ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Peritoneal Macrophages ◽  
Mouse Spleen ◽  
White Pulp ◽  
Leukocyte Integrins ◽  
Binding Function ◽  
Murine Homologue ◽  
Lymph Node Cells ◽  
Beta 2

Hybridoma fusions with hamster hosts were undertaken to generate mAbs to mouse spleen dendritic cells. Two mAb were obtained and used to uncover the distinct integrins of these APC. One, 2E6, bound a determinant common to all members of the CD11/CD18 family, most likely the shared 90 kD CD18 beta chain. 2E6 immunoprecipitated the characteristic beta 2 integrin heterodimers from lymphocytes (p180, 90; CD11a) and macrophages (p170,90; CD11b), but from dendritic cells, a p150,90 (presumably CD11c) integrin was the predominant species. 2E6 inhibited the binding function of the CD11a and CD11b integrins on B cells and macrophages in appropriate assays, but 2E6 exerted little or no inhibition on the clustering of dendritic cells to T cells early in primary MLR, suggesting a CD11/CD18-independent mechanism for this binding. The second mAb, N418, precipitated a 150, 90 kD heterodimer that shared the 2E6 CD18 epitope. This N418 epitope may be the murine homologue of the previously characterized human CD11c molecule, but the epitope was only detected on dendritic cells. N418 did not react with peritoneal macrophages, anti-Ig-induced spleen B blasts, or bulk lymph node cells. When used to stain sections of spleen, N418 stained dendritic cells in the T-dependent areas, much like anti-class II mAbs that were also generated in these fusions. In addition, N418 revealed nests of dendritic cells that punctuated the rim of marginal zone macrophages between red and white pulp. This localization positioned most dendritic cells at regions where arterial vessels and T cells enter the white pulp. We conclude that the p150, 90 heterodimer is the major beta 2 integrin of spleen dendritic cells, and we speculate that it may function to localize these APC at sites that permit access to the recirculating pool of resting T cells.

Functional insights on the polarized redistribution of leukocyte integrins and their ligands during leukocyte migration and immune interactions

2007 ◽  
Vol 218 (1) ◽  
pp. 147-164 ◽  
Author(s):  
Olga Barreiro ◽  
Hortensia de la Fuente ◽  
María Mittelbrunn ◽  
Francisco Sánchez-Madrid
Keyword(s):  
Leukocyte Migration ◽  
Leukocyte Integrins
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