Functional Imaging Probes to Study the Neural Bases of Behavior in Genetic Animal Models of ADHD

Identifying the neural mechanisms underlying spatial orientation and navigation has long posed a challenge for researchers. Multiple approaches incorporating a variety of techniques and animal models have been used to address this issue. More recently, virtual navigation has become a popular tool for understanding navigational processes. Although combining this technique with functional imaging can provide important information on many aspects of spatial navigation, it is important to recognize some of the limitations these techniques have for gaining a complete understanding of the neural mechanisms of navigation. Foremost among these is that, when participants perform a virtual navigation task in a scanner, they are lying motionless in a supine position while viewing a video monitor. Here, we provide evidence that spatial orientation and navigation rely to a large extent on locomotion and its accompanying activation of motor, vestibular, and proprioceptive systems. Researchers should therefore consider the impact on the absence of these motion-based systems when interpreting virtual navigation/functional imaging experiments to achieve a more accurate understanding of the mechanisms underlying navigation.

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Development of imaging probes for bone cancer in animal models. A systematic review

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2016.08.039 ◽

2016 ◽

Vol 83 ◽

pp. 1253-1264 ◽

Cited By ~ 5

Author(s):

Renata Salgado Fernandes ◽

Diego dos Santos Ferreira ◽

Carolina de Aguiar Ferreira ◽

Francesco Giammarile ◽

Domenico Rubello ◽

...

Keyword(s):

Systematic Review ◽

Animal Models ◽

Bone Cancer ◽

Imaging Probes

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Functional imaging of tumor vascular network in small animal models

10.1117/12.890746 ◽

2011 ◽

Author(s):

Vyacheslav Kalchenko ◽

Noa Madar-Balakirski ◽

Yuri Kuznetsov ◽

Igor Meglinski ◽

Alon Harmelin

Keyword(s):

Animal Models ◽

Functional Imaging ◽

Small Animal ◽

Vascular Network ◽

Small Animal Models

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Spatial and temporal processing for functional imaging probes

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) ◽

10.1109/nssmic.2014.7430819 ◽

2014 ◽

Author(s):

Mingwu Jin ◽

Cong Zhao ◽

Jaehoon Yu ◽

Wei Chen ◽

Guiyang Hao ◽

...

Keyword(s):

Functional Imaging ◽

Temporal Processing ◽

Imaging Probes

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Functional definitions of parietal areas in human and non-human primates

Proceedings of The Royal Society B Biological Sciences ◽

10.1098/rspb.2016.0118 ◽

2016 ◽

Vol 283 (1828) ◽

pp. 20160118 ◽

Cited By ~ 33

Author(s):

Guy A. Orban

Keyword(s):

Animal Models ◽

Human Brain ◽

Functional Imaging ◽

Tool Use ◽

Action Planning ◽

Supramarginal Gyrus ◽

Translational Neuroscience ◽

Cortical Areas

Establishing homologies between cortical areas in animal models and humans lies at the heart of translational neuroscience, as it demonstrates how knowledge obtained from these models can be applied to the human brain. Here, we review progress in using parallel functional imaging to ascertain homologies between parietal areas of human and non-human primates, species sharing similar behavioural repertoires. The human homologues of several areas along monkey IPS involved in action planning and observation, such as AIP, LIP and CIP, as well as those of opercular areas (SII complex), have been defined. In addition, uniquely human areas, such as the tool-use area in left anterior supramarginal gyrus, have also been identified.

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Reductionist thinking and animal models in neuropsychiatric research

Behavioral and Brain Sciences ◽

10.1017/s0140525x18001231 ◽

2019 ◽

Vol 42 ◽

Cited By ~ 1

Author(s):

Nicole M. Baran

Keyword(s):

Animal Models ◽

Mental Disorders ◽

Environmental Factors ◽

Neuropsychiatric Disorders ◽

Model Organisms ◽

Developmental Genetic ◽

Term Study ◽

Genetic And Environmental Factors ◽

Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

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Lessons From the Neural Bases of Speech and Voice

Perspectives on Speech Science and Orofacial Disorders ◽

10.1044/ssod21.1.5 ◽

2011 ◽

Vol 21 (1) ◽

pp. 5-14

Author(s):

Christy L. Ludlow

Keyword(s):

Brain Networks ◽

Neural Substrates ◽

Voice Behavior ◽

Therapeutic Approaches ◽

Neural Bases ◽

Sound Foundation ◽

The Brain ◽

Normal Speech

The premise of this article is that increased understanding of the brain bases for normal speech and voice behavior will provide a sound foundation for developing therapeutic approaches to establish or re-establish these functions. The neural substrates involved in speech/voice behaviors, the types of muscle patterning for speech and voice, the brain networks involved and their regulation, and how they can be externally modulated for improving function will be addressed.

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