Development of Novel Antioxidants

2014 ◽  
pp. 349-367
Author(s):  
Subhabrata Moitra ◽  
Sneha Limaye ◽  
Bill Brashier
Keyword(s):  
Novel Antioxidants

scholarly journals Antioxidants in Fish Sperm and the Potential Role of Melatonin

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 36
Author(s):  
Francisca Félix ◽  
Catarina C. V. Oliveira ◽  
Elsa Cabrita
Keyword(s):  
Oxidative Stress ◽  
Fish Cell ◽  
Cell Protection ◽  
Factors Affecting ◽  
Fish Sperm ◽  
Scavenger Activity ◽  
Stress Damage ◽  
Novel Antioxidants ◽  
Aquaculture Production

In recent years, the effects of novel antioxidants have played an important role in the research focusing on fish cell protection. As food demand grows, aquaculture production becomes more intensive, and fish are more exposed to oxidative stress conditions, like high densities, temperature shifting, frequent fish handling and samplings, and prophylactic or disease treatments, which expose fish to a different environment. Particularly in reproduction, germ cells lose antioxidant capacity with spermatogenesis, as spermatozoa are more prone to oxidative stress. Antioxidants have been used in a variety of fish physiological problems including in reproduction and in the establishment of cryopreservation protocols. From the most used antioxidants to natural plant food and herbs, and endogenously produced antioxidants, like melatonin, a review of the literature available in terms of their effects on the protection of fish spermatozoa is presented here in a classified structure. Several direct and indirect approaches to improve gamete quality using antioxidants administration are mentioned (through feed supplementation or by adding in cryopreservation media), as well as factors affecting the efficiency of these molecules and their mechanisms of action. Special attention is given to the unclear melatonin pathway and its potential scavenger activity to prevent and counteract oxidative stress damage on fish spermatozoa.

ChemInform Abstract: 2,6-Diamino-3,5-diaryl-1,4-pyrazine Derivatives as Novel Antioxidants.

ChemInform ◽  
2010 ◽  
Vol 32 (33) ◽  
pp. no-no
Author(s):  
Jean-Francois Cavalier ◽  
Maggi Burton ◽  
Catherine De Tollenaere ◽  
Frederique Dussart ◽  
Cecile Marchand ◽  
...  
Keyword(s):  
Novel Antioxidants

Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties

2003 ◽  
Vol 13 (14) ◽  
pp. 2273-2275 ◽  
Author(s):  
Kyung-Mi Kim ◽  
Kyung-Hwa Kim ◽  
Tae-Cheon Kang ◽  
Won-Yeon Kim ◽  
Myung-ryul Lee ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Novel Antioxidants

Novel antioxidants isolated from plants of the genera Ferula, Inula, Prangos and Rheum collected in Uzbekistan

Phytomedicine ◽  
2004 ◽  
Vol 11 (7-8) ◽  
pp. 645-651 ◽  
Author(s):  
K. Kogure ◽  
I. Yamauchi ◽  
A. Tokumura ◽  
K. Kondou ◽  
N. Tanaka ◽  
...  
Keyword(s):  
Novel Antioxidants

scholarly journals Antioxidants from the Leaves of Cinnamomum kotoense

2010 ◽  
Vol 5 (6) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Kuo-Chen Cheng ◽  
Man-Chun Hsueh ◽  
Hou-Chien Chang ◽  
Alan Yueh-Luen Lee ◽  
Hui-Min Wang ◽  
...  
Keyword(s):  
Potential Role ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Natural Antioxidants ◽  
Scavenging Activity ◽  
Dpph Radical ◽  
Dpph Radical Scavenging Activity ◽  
Novel Antioxidants ◽  
Dpph Radical Scavenging

Two novel antioxidants, obtusilactone A (1) and (-)-sesamin (2) have been identified in Cinnamomum kotoense Kanehira. Both showed effective 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared with vitamin C, and reducing power compared with BHA. These results suggest that these constituents of C. kotoense act as natural antioxidants and play a potential role in cancer prevention.

6-Hydroxychroman-2-carboxylic acids: Novel antioxidants

1974 ◽  
Vol 51 (5) ◽  
pp. 200-203 ◽  
Author(s):  
John W. Scott ◽  
Winifred M. Cort ◽  
Hampton Harley ◽  
David R. Parrish ◽  
Gabriel Saucy
Keyword(s):  
Carboxylic Acids ◽  
Novel Antioxidants

DFT Study on Molecular Structures and ROS Scavenging Mechanisms of Novel Antioxidants fromLespedeza Virgata

2011 ◽  
Vol 24 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Min-jie Li ◽  
Liang-miao Zhang ◽  
Wei-xia Liu ◽  
Wen-cong Lu
Keyword(s):  
Molecular Structures ◽  
Dft Study ◽  
Ros Scavenging ◽  
Novel Antioxidants

Lipophilized Epigallocatechin Gallate (EGCG) Derivatives as Novel Antioxidants

2011 ◽  
Vol 59 (12) ◽  
pp. 6526-6533 ◽  
Author(s):  
Ying Zhong ◽  
Fereidoon Shahidi
Keyword(s):  
Epigallocatechin Gallate ◽  
Novel Antioxidants

scholarly journals Protective effect of placenta extracts against nitrite-induced oxidative stress in human erythrocytes

2012 ◽  
Vol 17 (2) ◽  
Author(s):  
Svitlana Rozanova ◽  
Yana Cherkashina ◽  
Svitlana Repina ◽  
Katherina Rozanova ◽  
Oleg Nardid
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Protein Conformation ◽  
Biological Models ◽  
High Concentration ◽  
Bioactive Substances ◽  
Structural Dynamic ◽  
Spin Resonance ◽  
Extract Fraction ◽  
Novel Antioxidants

AbstractAqueous-saline human placenta extract (HPE) is known to possess antioxidant activity due to the high concentration of bioactive substances. This fact allows its application in clinical practice in order to treat oxidation-induced diseases. Extract antioxidant activity is mainly conditioned by proteins. Freezing of extracts has been shown to lead to their antioxidant activity increasing due to protein conformation changes.Different biological models are widely used in order to evaluate efficacy of novel antioxidants and mechanisms of their action. One such model appears to be erythrocytes under nitrite-induced oxidative stress. Nitrite is known to be able to penetrate erythrocyte membrane and to oxidize hemoglobin. In order to investigate whether HPE is able to decrease nitrite-induced oxidative injuries and to evaluate the protein contribution to this process, spectrophotometric and electron spin resonance (ESR) assays were used.Experimental data have revealed that antioxidant activity of extracts and of some of their fractions correlates with methemoglobin concentration lowering. Preliminary erythrocyte incubation with an extract fraction of 12 kDa allows preservation of the structural-dynamic cytosol state the closest to the control.

Sign in / Sign up

Export Citation Format

Share Document