Pulmonary Infections—Oxidant Injury and Role of Antioxidants

2014 ◽  
pp. 85-99
Author(s):  
Bidyalaxmi Devi Leishangthem ◽  
Ruchi Rastogi ◽  
Archana Bhatnagar
Keyword(s):  
Pulmonary Infections ◽  
Oxidant Injury

scholarly journals Role of intrinsic antioxidant enzymes in renal oxidant injury

1990 ◽  
Vol 38 (2) ◽  
pp. 282-288 ◽  
Author(s):  
Toshimasa Yoshioka ◽  
Teresa Bills ◽  
Tracy Moore-Jarrett ◽  
Harry L. Greene ◽  
Ian M. Burr ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Oxidant Injury

Dang-Gui Buxue Tang Protects against Oxidant Injury by Enhancing Cellular Glutathione in H9c2 Cells: Role of Glutathione Synthesis and Regeneration

Planta Medica ◽  
2007 ◽  
Vol 73 (2) ◽  
pp. 134-141 ◽  
Author(s):  
Po Chiu ◽  
Hoi Leung ◽  
Ada Siu ◽  
Michel Poon ◽  
Tina Dong ◽  
...  
Keyword(s):  
H9c2 Cells ◽  
Oxidant Injury ◽  
Glutathione Synthesis

scholarly journals The Role of P53 in Sepsis-Induced Cardiomyopathy

2021 ◽  
Vol 26 (3) ◽  
pp. 45-47
Author(s):  
Peter Michael Reil ◽  
Teodor Traian Maghiar ◽  
Karlheinz Seidl ◽  
Claudia Teodora Judea Pusta ◽  
Ciprian Borza ◽  
...  
Keyword(s):  
Cardiac Tissue ◽  
Medical Problem ◽  
Statistical Correlation ◽  
Control Group ◽  
Study Group ◽  
Septic Cardiomyopathy ◽  
Pulmonary Infections ◽  
P53 Expression ◽  
The Difference

Abstract Septic cardiomyopathy remains a difficult medical problem to manage in critically ill patients. With all currently available therapeutic options, the mortality rate in these patients remains high. Our study included 29 patients diagnosed clinically with sepsis. A control group was used to compare the results. In all patients, p53 expression was assessed in cardiac tissue obtained from these patients and a statistical correlation was made with clinical data. The different expression rates of p53 do not correlate with patient’s age, having appropriate means in years, but with an increasing tendency with increasing expression (p=0.2110). The pulmonary infections are responsible for the majority of the septic state in the study group (over 55%). The difference between the infection sites is statistically significant (p<0.0001).

scholarly journals Successful Management of Sequential Pulmonary Infections in a Cardiac Transplant Recipient

1990 ◽  
Vol 1 (3) ◽  
pp. 85-91 ◽  
Author(s):  
John Galbraith ◽  
Jutta K Preiksaitis ◽  
Sandra Czekanski ◽  
Mark J Poznansky ◽  
Mohamed Hirji
Keyword(s):  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Nocardia Asteroides ◽  
Cardiac Transplant ◽  
Pulmonary Infections ◽  
Computed Tomographic ◽  
Cardiac Transplant Recipient ◽  
Syncytial Virus

A case of a cardiac allograft recipient who had an initial combined pulmonary infection with cytomegalovirus,Aspergillus fumigatusandNocardia asteroides,successfully treated with liposomal amphotericin B and sulfisoxazole and followed by an episode of respiratory syncytial virus pneumonitis, is presented. This case illustrates the role of computed tomographic imaging in the recognition, diagnosis and monitoring of complex opportunistic pulmonary infections and the benefits of liposomal amphotericin B in the treatment of aspergillosis.

scholarly journals Role of therapeutic drug monitoring in pulmonary infections: use and potential for expanded use of dried blood spot samples

Bioanalysis ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 481-495 ◽  
Author(s):  
Susan Hofman ◽  
Mathieu S Bolhuis ◽  
Remco A Koster ◽  
Onno W Akkerman ◽  
Sander van Assen ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Dried Blood Spot ◽  
Therapeutic Drug ◽  
Pulmonary Infections ◽  
Blood Spot

scholarly journals Role of cytokine profile in the differential diagnosis between acute lung rejection and pulmonary infections after lung transplantation†

2014 ◽  
Vol 47 (6) ◽  
pp. 1031-1036 ◽  
Author(s):  
Miriam Patella ◽  
Marco Anile ◽  
Paola Del Porto ◽  
Daniele Diso ◽  
Ylenia Pecoraro ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Lung Transplantation ◽  
Cytokine Profile ◽  
Pulmonary Infections

scholarly journals Role of matrix metalloprotease-9 in hyperoxic injury in developing lung

2008 ◽  
Vol 295 (4) ◽  
pp. L584-L592 ◽  
Author(s):  
Anne Chetty ◽  
Gong-Jie Cao ◽  
Mariano Severgnini ◽  
Amy Simon ◽  
Rod Warburton ◽  
...  
Keyword(s):  
Lung Injury ◽  
Structural Changes ◽  
Type I Collagen ◽  
Alveolar Epithelium ◽  
Mouse Lung ◽  
Type I ◽  
Matrix Metalloprotease ◽  
Oxidant Injury ◽  
Hyperoxia Exposure

Matrix metalloprotease-9 (MMP-9) is increased in lung injury following hyperoxia exposure in neonatal mice, in association with impaired alveolar development. We studied the role of MMP-9 in the mechanism of hyperoxia-induced functional and histological changes in neonatal mouse lung. Reduced alveolarization with remodeling of ECM is a major morbidity component of oxidant injury in developing lung. MMP-9 mediates oxidant injury in developing lung causing altered lung remodeling. Five-day-old neonatal wild-type (WT) and MMP-9 (−/−) mice were exposed to hyperoxia for 8 days. The lungs were inflation fixed, and sections were examined for morphometry. The mean linear intercept and alveolar counts were evaluated. Immunohistochemistry for MMP-9 and elastin was performed. MMP-2, MMP-9, type I collagen, and tropoelastin were measured by Western blot analysis. Lung quasistatic compliance was studied in anaesthetized mice. MMP-2 and MMP-9 were significantly increased in lungs of WT mice exposed to hyperoxia compared with controls. Immunohistochemistry showed an increase in MMP-9 in mesenchyme and alveolar epithelium of hyperoxic lungs. The lungs of hyperoxia-exposed WT mice had less gas exchange surface area and were less compliant compared with room air-exposed WT and hyperoxia-exposed MMP-9 (−/−) mice. Type I collagen and tropoelastin were increased in hyperoxia-exposed WT with aberrant elastin staining. These changes were ameliorated in hyperoxia-exposed MMP-9 (−/−) mice. MMP-9 plays an important role in the structural changes consequent to oxygen-induced lung injury. Blocking MMP-9 activity may lead to novel therapeutic approaches in preventing bronchopulmonary dysplasia.

Role of Bronchoalveolarlavage in the Diagnosis of Pulmonary Infections

2015 ◽  
Vol 1 (1) ◽  
pp. 110
Author(s):  
BC Stany ◽  
N Girish ◽  
CY Ranjini ◽  
K Leela Rani ◽  
A Dhanalaxmi ◽  
...  
Keyword(s):  
Pulmonary Infections
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