Generation of Mouse Lines Conditionally Over-expressing MicroRNA Using the Rosa26-Lox-Stop-Lox System

2014 ◽  
pp. 203-224 ◽  
Author(s):  
Claudia Piovan ◽  
Foued Amari ◽  
Francesca Lovat ◽  
Qun Chen ◽  
Vincenzo Coppola
Keyword(s):  
Mouse Lines

Fibrogenic genotype-phenotype correlations in selected BXD recombinant inbred mouse lines: Closer to life?!

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
N Fund ◽  
R Hall ◽  
S Dooley ◽  
F Lammert ◽  
R Müllenbach
Keyword(s):  
Recombinant Inbred ◽  
Inbred Mouse ◽  
Recombinant Inbred Mouse ◽  
Mouse Lines

Generation of inducible hepatitis C virus transgenic mouse lines

2006 ◽  
Vol 44 (01) ◽  
Author(s):  
E Ernst ◽  
K Schönig ◽  
H Bläker ◽  
W Stremmel ◽  
J Encke
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Transgenic Mouse ◽  
Mouse Lines

scholarly journals A resource of targeted mutant mouse lines for 5,061 genes

2021 ◽  
Author(s):  
Marie-Christine Birling ◽  
◽  
Atsushi Yoshiki ◽  
David J. Adams ◽  
Shinya Ayabe ◽  
...  
Keyword(s):  
Mutant Mouse ◽  
Mouse Lines

scholarly journals Studying the pharmacogenomic effect of cranberry extract on reducing body weight using collaborative cross mice

2021 ◽  
Author(s):  
Fatima Amer-Sarsour ◽  
Rawan Abu Saleh ◽  
Itzhak Ofek ◽  
Fuad A. Iraqi
Keyword(s):  
Body Weight ◽  
Collaborative Cross ◽  
Diverse Backgrounds ◽  
Mouse Lines

The non-dialyzable material (NDM) of polyphenol-rich cranberry extract (CRE) powder (NDM-CRE) was studied for its effect of inducing body weight (BW) loss in 13 different mouse lines with well-defined genetically diverse backgrounds, named the collaborative cross (CC).

scholarly journals CYP1A1 and CYP1A2 expression: Comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

2009 ◽  
Vol 237 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Shigeyuki Uno ◽  
Kaori Endo ◽  
Yuji Ishida ◽  
Chise Tateno ◽  
Makoto Makishima ◽  
...  
Keyword(s):  
Cell Lines ◽  
Wild Type ◽  
Humanized Mouse ◽  
Mouse Hepatoma ◽  
Human And Mouse ◽  
Mouse Lines

scholarly journals Chimeric elk/mouse prion proteins in transgenic mice

2013 ◽  
Vol 94 (2) ◽  
pp. 443-452 ◽  
Author(s):  
Gültekin Tamgüney ◽  
Kurt Giles ◽  
Abby Oehler ◽  
Natrina L. Johnson ◽  
Stephen J. DeArmond ◽  
...  
Keyword(s):  
Neurodegenerative Disorder ◽  
Prion Proteins ◽  
Second Line ◽  
Mouse Line ◽  
Wasting Disease ◽  
C Terminus ◽  
Incubation Periods ◽  
N Terminus ◽  
Mouse Lines

Chronic wasting disease (CWD) of deer and elk is a highly communicable neurodegenerative disorder caused by prions. Investigations of CWD are hampered by slow bioassays in transgenic (Tg) mice. Towards the development of Tg mice that will be more susceptible to CWD prions, we created a series of chimeric elk/mouse transgenes that encode the N terminus of elk PrP (ElkPrP) up to residue Y168 and the C terminus of mouse PrP (MoPrP) beyond residue 169 (mouse numbering), designated Elk3M(SNIVVK). Between codons 169 and 219, six residues distinguish ElkPrP from MoPrP: N169S, T173N, V183I, I202V, I214V and R219K. Using chimeric elk/mouse PrP constructs, we generated 12 Tg mouse lines and determined incubation times after intracerebral inoculation with the mouse-passaged RML scrapie or Elk1P CWD prions. Unexpectedly, one Tg mouse line expressing Elk3M(SNIVVK) exhibited incubation times of <70 days when inoculated with RML prions; a second line had incubation times of <90 days. In contrast, mice expressing full-length ElkPrP had incubation periods of >250 days for RML prions. Tg(Elk3M,SNIVVK) mice were less susceptible to CWD prions than Tg(ElkPrP) mice. Changing three C-terminal mouse residues (202, 214 and 219) to those of elk doubled the incubation time for mouse RML prions and rendered the mice resistant to Elk1P CWD prions. Mutating an additional two residues from mouse to elk at codons 169 and 173 increased the incubation times for mouse prions to >300 days, but made the mice susceptible to CWD prions. Our findings highlight the role of C-terminal residues in PrP that control the susceptibility and replication of prions.

scholarly journals Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-γ as Contributing to Enhanced Malaria Survival

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10903 ◽  
Author(s):  
Selina E. R. Bopp ◽  
Vandana Ramachandran ◽  
Kerstin Henson ◽  
Angelina Luzader ◽  
Merle Lindstrom ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Genome Wide Analysis ◽  
Ppar Γ ◽  
Genome Wide ◽  
Mouse Lines

C4 Motivation and reward seeking in HD mouse lines: possible association with ventral striatal mHTT load and dopamine receptor loss

2016 ◽  
Vol 87 (Suppl 1) ◽  
pp. A28.1-A28
Author(s):  
Kyle Fears ◽  
Timothy Stone ◽  
Linda Elliston ◽  
Zubeyde Bayram-Weston ◽  
David Harrison ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Reward Seeking ◽  
Mouse Lines

Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons

2012 ◽  
Vol 35 (4) ◽  
pp. 527-538 ◽  
Author(s):  
Noémie Bérubé-Carrière ◽  
Ginette Guay ◽  
Guillaume M. Fortin ◽  
Klas Kullander ◽  
Lars Olson ◽  
...  
Keyword(s):  
Dopamine Neurons ◽  
Ultrastructural Characterization ◽  
Dopamine Innervation ◽  
Mouse Lines
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