Immunocytochemical Identification of Mammalian Differentiating Neurons in the Process of Adult Neurogenesis in the Hippocampal Dentate Gyrus

2015 ◽  
pp. 109-122 ◽  
Author(s):  
Oliver von Bohlen und Halbach
Keyword(s):  
Dentate Gyrus ◽  
Adult Neurogenesis ◽  
Hippocampal Dentate Gyrus

Oroxylin A, a Flavonoid, Stimulates Adult Neurogenesis in the Hippocampal Dentate Gyrus Region of Mice

2010 ◽  
Vol 35 (11) ◽  
pp. 1725-1732 ◽  
Author(s):  
Seungjoo Lee ◽  
Dong Hyun Kim ◽  
Dong Hwa Lee ◽  
Su Jin Jeon ◽  
Chang Hwan Lee ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Adult Neurogenesis ◽  
Oroxylin A ◽  
Hippocampal Dentate Gyrus ◽  
Dentate Gyrus Region

scholarly journals Astragaloside IV Promotes Adult Neurogenesis in Hippocampal Dentate Gyrus of Mouse through CXCL1/CXCR2 Signaling

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2178 ◽  
Author(s):  
Fei Huang ◽  
Yunyi Lan ◽  
Liyue Qin ◽  
Huaihuai Dong ◽  
Hailian Shi ◽  
...  
Keyword(s):  
Protein Expression ◽  
Dentate Gyrus ◽  
Adult Neurogenesis ◽  
Astragaloside Iv ◽  
Hippocampal Dentate Gyrus ◽  
Promotive Effect ◽  
Mature Neurons ◽  
Underlying Mechanisms ◽  
Proliferation In Vitro

Astragaloside IV (ASI) has been reported to promote neural stem cells proliferation in vitro and CXCR2 expression on neutrophils. The present study was aimed to investigate the influence of ASI on adult neurogenesis in hippocampal dentate gyrus (DGs) of mouse and to discuss the possible underlying mechanisms. Total number of proliferative cells (BrdU+), pre-mature neurons (DCX+), early proliferative cells (BrdU+/DCX+), proliferative radial gila-like cells (BrdU+/GFAP+) and newly generated neurons (BrdU+/NeuN+) after ASI or vehicle administration for two weeks were counted, respectively. The results showed that BrdU+ cells and DCX+ cells were significantly increased in DGs of mice administered with ASI. The numbers of BrdU+/DCX+, BrdU+/GFAP+ cells and BrdU+/NeuN+ cells were also elevated in the ASI group. Correspondingly, ASI increased the protein expression of hippocampal DCX, GFAP and NeuN. Further study disclosed that ASI remarkably up-regulated the mRNA and protein expressions of CXCL1 as well as that of CXCR2 in the hippocampus. The promotive effect of ASI on DCX, GFAP and NeuN protein expression was abolished by SB225002, the inhibitor of CXCR2. Our results indicated that ASI modulated the homeostasis of the CXCL1/CXCR2 signaling pathway, which might be responsible for the increased neurogenesis within the hippocampal DGs of mice.

CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus

2017 ◽  
Vol 661 ◽  
pp. 121-125 ◽  
Author(s):  
Kaori Yagishita ◽  
Ritsuko Suzuki ◽  
Shota Mizuno ◽  
Ritsuko Katoh-Semba ◽  
Tetsushi Sadakata ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Adult Neurogenesis ◽  
Environmental Enrichment ◽  
Hippocampal Dentate Gyrus ◽  
Newborn Neurons

scholarly journals Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zheng Yu ◽  
Dong Lin ◽  
Yanzi Zhong ◽  
Bin Luo ◽  
Shengsheng Liu ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Adult Neurogenesis ◽  
Transmembrane Protein ◽  
Hippocampal Dentate Gyrus

Adult Neurogenesis and Synaptic Rewiring in the Hippocampal Dentate Gyrus

2017 ◽  
pp. 389-408
Author(s):  
Arjen van Ooyen ◽  
Gertraud Teuchert-Noodt ◽  
Keren Grafen ◽  
Markus Butz-Ostendorf
Keyword(s):  
Dentate Gyrus ◽  
Adult Neurogenesis ◽  
Hippocampal Dentate Gyrus

Sustained increase in adult neurogenesis in the rat hippocampal dentate gyrus after transient brain ischemia

2011 ◽  
Vol 488 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Congmin Wang ◽  
Mingguang Zhang ◽  
Chifei Sun ◽  
Yuqun Cai ◽  
Yan You ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Brain Ischemia ◽  
Adult Neurogenesis ◽  
Hippocampal Dentate Gyrus ◽  
Sustained Increase

scholarly journals Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus

2015 ◽  
Vol 16 (3) ◽  
pp. 245 ◽  
Author(s):  
Sung Min Nam ◽  
Jong Whi Kim ◽  
Dae Young Yoo ◽  
Jung Hoon Choi ◽  
Woosuk Kim ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Adult Neurogenesis ◽  
Cyclooxygenase 2 ◽  
Hippocampal Dentate Gyrus

scholarly journals Adult Neurogenesis in the Hippocampus From a Perspective of Discrimination and Generalization: A Hypothesis

2017 ◽  
pp. 441-448 ◽  
Author(s):  
A. PISTIKOVA ◽  
H. BROZKA ◽  
A. STUCHLIK
Keyword(s):  
Dentate Gyrus ◽  
Continuous Spectrum ◽  
Adult Neurogenesis ◽  
The Other ◽  
Testable Hypothesis ◽  
Behavioral Tests ◽  
Hippocampal Dentate Gyrus ◽  
Other Hand ◽  
Behavioral Tasks

The function of adult neurogenesis in the dentate gyrus is not yet completely understood, though many competing theories have attempted to explain the function of these newly-generated neurons. Most theories give adult neurogenesis a role in aiding known hippocampal/dentate gyrus functions. Other theories offer a novel role for these new cells based on their unique physiological qualities, such as their low excitability threshold. Many behavioral tests have been used to test these theories, but results have been inconsistent and often contradictory. Substantial variability in tests and protocols may be at least partially responsible for the mixed results. On the other hand, conflicting results arising from the same tests can serve as aids in elucidating the function of adult neurogenesis. Here, we offer a hypothesis that considers the cognitive nature of tasks commonly used to assess the function of adult neurogenesis, and introduce a dichotomy between tasks focused on discrimination vs. generalization. We view these two aspects as opposite ends of the continuous spectrum onto which traditional tests can be mapped. We propose that high neurogenesis favors behavioral discrimination while low adult neurogenesis favors behavioral generalization of a knowledge or rule. Since many tasks require both, the effects of neurogenesis could be cancelled out in many cases. Although speculative, we hope that our view presents an interesting and testable hypothesis of the effect of adult neurogenesis in traditional behavioral tasks. We conclude that new, carefully designed behavioral tests may be necessary to reach a final consensus on the role of adult neurogenesis in behavior.

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

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