Modeling Blood Flow Control in the Kidney

2015 ◽  
pp. 55-73
Author(s):  
Julia Arciero ◽  
Laura Ellwein ◽  
Ashlee N. Ford Versypt ◽  
Elizabeth Makrides ◽  
Anita T. Layton
Keyword(s):  
Blood Flow ◽  
Flow Control ◽  
Blood Flow Control

Communication Among Endothelial and Smooth Muscle Cells Coordinates Blood Flow Control During Exercise

Physiology ◽  
1992 ◽  
Vol 7 (4) ◽  
pp. 152-156 ◽  
Author(s):  
SS Segal
Keyword(s):  
Blood Flow ◽  
Smooth Muscle ◽  
Endothelial Cell ◽  
Locus Of Control ◽  
Smooth Muscle Cells ◽  
Flow Control ◽  
Muscle Cells ◽  
Peripheral Blood Flow ◽  
Metabolic Demand ◽  
Blood Flow Control

Peripheral blood flow control during exercise is coordinated among several vascular locations. The locus of control shifts upstream from distal arterioles into feeding arteries as metabolic demand increases. This shift occurs by cell-to-cell conduction and by flow-dependent endothelial cell-mediated relaxation of smooth muscle cells.

scholarly journals Blood Flow Control by ATP-Sensitive Potassium Channel in Heart

2019 ◽  
Vol 116 (3) ◽  
pp. 31a-32a
Author(s):  
Guiling Zhao ◽  
Humberto C. Joca ◽  
W. Jonathan Lederer
Keyword(s):  
Blood Flow ◽  
Flow Control ◽  
Potassium Channel ◽  
Blood Flow Control

Estrogen modulates the contribution of neuropeptide Y to baseline hindlimb blood flow control in female Sprague-Dawley rats

2010 ◽  
Vol 298 (5) ◽  
pp. R1351-R1357 ◽  
Author(s):  
Dwayne N. Jackson ◽  
Christopher G. Ellis ◽  
J. Kevin Shoemaker
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Flow Control ◽  
Neuropeptide Y ◽  
Female Rats ◽  
Vastus Lateralis Muscle ◽  
Peptidase Activity ◽  
Vascular Conductance ◽  
Ovx Rats ◽  
Blood Flow Control

The purpose of this study was to determine the role of estrogen in neuropeptide Y (NPY) and Y1 receptor (Y1R)-mediated vascular responses in female rats. Based on earlier work from our laboratory that female rats lacked an NPY contribution to hindlimb vascular conductance relative to males, we tested the hypothesis that estrogen modulates Y1R-mediated hindlimb blood flow control. Thus it was expected that ovariectomy would: 1) increase skeletal muscle Y1R expression, 2) decrease skeletal muscle Y2 receptor (Y2R) expression, 3) decrease peptidase activity, and/or 4) increase overall skeletal muscle NPY concentration. Separate groups of control (CTL), ovariectomized (OVX), and OVX + 17β-estradiol replacement (OVX + E2; 21-day pellet) rats were studied. Animals were anesthetized and given localized hindlimb delivery of BIBP-3226 (Y1R antagonist), while femoral artery blood flow and blood pressure were recorded. Tissue samples from the white and red vastus lateralis muscle were extracted to examine Y1R and Y2R expression, peptidase activity, and NPY concentration. We found that Y1R blockade resulted in increased baseline hindlimb blood flow and vascular conductance in OVX rats, whereas no change was noted in CTL or OVX + E2 groups ( P < 0.05). This enhanced functional effect in the OVX group aligned with greater skeletal muscle Y1R expression in white vastus muscle and a substantial increase in NPY concentration in both white and red vastus muscle compared with CTL and OVX + E2 groups. There was no change in Y2R expression or peptidase activity among the groups. These data support the hypothesis that estrogen blunts Y1R activation in the rat hindlimb through an effect on Y1R expression and NPY concentration.

Sign in / Sign up

Export Citation Format

Share Document