VEGF Gene Transfer to the Utero-Placental Circulation of Pregnant Guinea Pigs to Enhance Fetal Growth

2015 ◽  
pp. 189-196
Author(s):  
Vedanta Mehta ◽  
David J. Carr ◽  
Anna Swanson ◽  
Anna L. David
Keyword(s):  
Gene Transfer ◽  
Fetal Growth ◽  
Guinea Pigs ◽  
Vegf Gene

VEGF Gene Transfer to the Utero-Placental Circulation of Pregnant Sheep to Enhance Fetal Growth

2015 ◽  
pp. 197-204 ◽  
Author(s):  
David J. Carr ◽  
Vedanta Mehta ◽  
Jacqueline M. Wallace ◽  
Anna L. David
Keyword(s):  
Gene Transfer ◽  
Fetal Growth ◽  
Vegf Gene ◽  
Pregnant Sheep

HGF or VEGF gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
T Deuse ◽  
W Zimmermann ◽  
T Eschenhagen ◽  
H Reichenspurner ◽  
RC Robbins ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cell ◽  
Gene Transfer ◽  
Mesenchymal Stem Cell ◽  
Myocardial Salvage ◽  
Vegf Gene

scholarly journals Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with increased brain apoptosis

2018 ◽  
Vol 85 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Andrew Ghaly ◽  
Yohei Maki ◽  
Karen Nygard ◽  
Robert Hammond ◽  
Daniel B. Hardy ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Guinea Pigs ◽  
Growth Restriction ◽  
Nutrient Restriction

Maternal Nutrient Restriction in Guinea Pigs as an Animal Model for Inducing Fetal Growth Restriction

2015 ◽  
Vol 23 (2) ◽  
pp. 219-227 ◽  
Author(s):  
Alexander A. Elias ◽  
Andrew Ghaly ◽  
Brad Matushewski ◽  
Timothy R. H. Regnault ◽  
Bryan S. Richardson
Keyword(s):  
Animal Model ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Guinea Pigs ◽  
Growth Restriction ◽  
Nutrient Restriction

025 Modulation of Wound Repair in the Obese Diabetic Mouse: a Role for VEGF Gene Transfer

2004 ◽  
Vol 12 (2) ◽  
pp. A9-A9
Author(s):  
SB Schwartz ◽  
B McCampbell ◽  
R Garone ◽  
Z Vodslon ◽  
E Tokarcsik ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Wound Repair ◽  
Diabetic Mouse ◽  
Vegf Gene

HGF, VEGF gene transfer into CNS successful

2002 ◽  
Vol &NA; (1345) ◽  
pp. 11
Author(s):  
&NA;
Keyword(s):  
Gene Transfer ◽  
Vegf Gene

scholarly journals 273.Insulin-like growth factor treatment of pregnant guinea pigs during early pregnancy promotes fetal growth

2004 ◽  
Vol 16 (9) ◽  
pp. 273
Author(s):  
A. N. Sferruzzi-Perri ◽  
J. A. Owens ◽  
J. S. Robinson ◽  
C. T. Roberts
Keyword(s):  
Growth Factor ◽  
Fetal Growth ◽  
Early Pregnancy ◽  
Guinea Pigs ◽  
Placental Weight ◽  
Fetal Weight ◽  
Abdominal Circumference ◽  
Insulin Like Growth Factor ◽  
Crown Rump Length ◽  
Igf I

Insulin-like growth factor (IGF)-II is an important regulator of growth in many tissues and is abundantly expressed in the placenta during pregnancy. Gene ablation studies performed in mice have shown that IGF-II deficiency results in both impaired fetal and placental growth, whereas deficiency in IGF-I reduces fetal growth only. Conversely, maternal IGF supplementation in early pregnancy in the guinea pig increases placental and fetal size by mid pregnancy. This study aimed to determine whether these anabolic effects persist into late pregnancy after cessation of treatment. On Day 20 of pregnancy, mothers were anaesthetised and a mini osmotic pump was implanted subcutaneously, to deliver 1mg/kg/day IGF-I (n = 7), IGF-II (n = 9) or vehicle (n = 7) for 17 days. Guinea pigs were killed on Day 62 of pregnancy (term ~67 days). Fetal and placental weights, and maternal and fetal body composition, were measured. Total litter size was unaffected by IGF treatment; however, IGF-II increased the number of viable fetuses by 26% (P = 0.01). After adjusting for the number of viable pups per litter, maternal IGF treatment increased fetal growth by increasing abdominal circumference, crown-rump length and fetal weight (fetal weight: IGF-I 79+/–2.5 g; IGF-II 78+/–2.6 g; vs vehicle 68+/–2.5 g, P = 0.02). IGF treatment did not alter absolute or relative fetal organ weights. IGF-I reduced placental weight by 9% and IGF-II increased it by 9%, but not significantly. IGF-I increased the fetal weight�:�placental weight ratio (19+/–0.9 vs 15+/–0.9, respectively P = 0.043). IGF treatment did not affect maternal weight gain during pregnancy nor net carcass weight; however, IGF-I reduced maternal lung and adipose tissue weights. In conclusion, maternal IGF-II treatment during early pregnancy improved fetal growth into late gestation, possibly by modulating placental efficiency. As poor placental development is implicated in fetal growth restriction, increasing maternal IGF abundance in early to mid pregnancy may be a potential therapeutic approach to placental insufficiency.

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