025 Modulation of Wound Repair in the Obese Diabetic Mouse: a Role for VEGF Gene Transfer

2004 ◽  
Vol 12 (2) ◽  
pp. A9-A9
Author(s):  
SB Schwartz ◽  
B McCampbell ◽  
R Garone ◽  
Z Vodslon ◽  
E Tokarcsik ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Wound Repair ◽  
Diabetic Mouse ◽  
Vegf Gene

HGF or VEGF gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
T Deuse ◽  
W Zimmermann ◽  
T Eschenhagen ◽  
H Reichenspurner ◽  
RC Robbins ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stem Cell ◽  
Gene Transfer ◽  
Mesenchymal Stem Cell ◽  
Myocardial Salvage ◽  
Vegf Gene

Gene transfer of hepatocyte growth factor by electroporation reduces bleomycin-induced lung fibrosis

2007 ◽  
Vol 292 (2) ◽  
pp. L529-L536 ◽  
Author(s):  
Amiq Gazdhar ◽  
Patrick Fachinger ◽  
Coretta van Leer ◽  
Jaroslaw Pierog ◽  
Mathias Gugger ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Transfer ◽  
Pulmonary Fibrosis ◽  
Wound Repair ◽  
Alveolar Epithelial Cells ◽  
Epithelial Repair ◽  
Alveolar Epithelial ◽  
Hepatocyte Growth

Abnormal alveolar wound repair contributes to the development of pulmonary fibrosis after lung injury. Hepatocyte growth factor (HGF) is a potent mitogenic factor for alveolar epithelial cells and may therefore improve alveolar epithelial repair in vitro and in vivo. We hypothesized that HGF could increase alveolar epithelial repair in vitro and improve pulmonary fibrosis in vivo. Alveolar wound repair in vitro was determined using an epithelial wound repair model with HGF-transfected A549 alveolar epithelial cells. Electroporation-mediated, nonviral gene transfer of HGF in vivo was performed 7 days after bleomycin-induced lung injury in the rat. Alveolar epithelial repair in vitro was increased after transfection of wounded epithelial monolayers with a plasmid encoding human HGF, pCikhHGF [human HGF (hHGF) gene expressed from the cytomegalovirus (CMV) immediate-early promoter and enhancer] compared with medium control. Electroporation-mediated in vivo HGF gene transfer using pCikhHGF 7 days after intratracheal bleomycin reduced pulmonary fibrosis as assessed by histology and hydroxyproline determination 14 days after bleomycin compared with controls treated with the same vector not containing the HGF sequence (pCik). Lung epithelial cell proliferation was increased and apoptosis reduced in hHGF-treated lungs compared with controls, suggesting increased alveolar epithelial repair in vivo. In addition, profibrotic transforming growth factor-β1 (TGF-β1) was decreased in hHGF-treated lungs, indicating an involvement of TGF-β1 in hHGF-induced reduction of lung fibrosis. In conclusion, electroporation-mediated gene transfer of hHGF decreases bleomycin-induced pulmonary fibrosis, possibly by increasing alveolar epithelial cell proliferation and reducing apoptosis, resulting in improved alveolar wound repair.

HGF, VEGF gene transfer into CNS successful

2002 ◽  
Vol &NA; (1345) ◽  
pp. 11
Author(s):  
&NA;
Keyword(s):  
Gene Transfer ◽  
Vegf Gene

scholarly journals Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.

1998 ◽  
Vol 101 (5) ◽  
pp. 967-971 ◽  
Author(s):  
K Yamasaki ◽  
H D Edington ◽  
C McClosky ◽  
E Tzeng ◽  
A Lizonova ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Wound Repair ◽  
Inos Gene ◽  
Deficient Mice

scholarly journals Reversal of experimental diabetic neuropathy by VEGF gene transfer

2001 ◽  
Vol 107 (9) ◽  
pp. 1083-1092 ◽  
Author(s):  
Peter Schratzberger ◽  
Dirk H. Walter ◽  
Kilian Rittig ◽  
Ferdinand H. Bahlmann ◽  
Roberto Pola ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Diabetic Neuropathy ◽  
Vegf Gene ◽  
Experimental Diabetic Neuropathy

VEGF Gene Transfer to the Utero-Placental Circulation of Pregnant Guinea Pigs to Enhance Fetal Growth

2015 ◽  
pp. 189-196
Author(s):  
Vedanta Mehta ◽  
David J. Carr ◽  
Anna Swanson ◽  
Anna L. David
Keyword(s):  
Gene Transfer ◽  
Fetal Growth ◽  
Guinea Pigs ◽  
Vegf Gene
Sign in / Sign up

Export Citation Format

Share Document