Single-Cell Lineage Analysis of Oogenesis in Mice

2016 ◽  
pp. 125-138 ◽  
Author(s):  
Lei Lei ◽  
Allan C. Spradling
Keyword(s):  
Single Cell ◽  
Cell Lineage ◽  
Lineage Analysis

scholarly journals Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Christine E. Eyler ◽  
Hironori Matsunaga ◽  
Volker Hovestadt ◽  
Samantha J. Vantine ◽  
Peter van Galen ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Single Cell ◽  
Cell Lineage ◽  
Lineage Analysis

scholarly journals The clonal composition of biramous and uniramous arthropod limbs

2008 ◽  
Vol 275 (1638) ◽  
pp. 1023-1028 ◽  
Author(s):  
Carsten Wolff ◽  
Gerhard Scholtz
Keyword(s):  
Single Cell ◽  
Limb Development ◽  
Cell Lineage ◽  
Growth Zone ◽  
Cell Labelling ◽  
General Belief ◽  
Developmental Approach ◽  
Orchestia Cavimana ◽  
Clonal Composition ◽  
Lineage Analysis

We present the first comparative cell lineage analysis of uniramous and biramous limbs of an arthropod, the crustacean Orchestia cavimana . Via single cell labelling of the cells that are involved in limb development, we are able to present the first complete clonal composition of an arthropod limb. We show that the two main branches of crustacean limbs, exopod and endopod, are formed by a secondary subdivision of the growth zone of the main limb axis. Additional limb outgrowths such as exites result from the establishment of new axes. In contrast to general belief, uniramous limbs in Orchestia are not formed by the loss of the exopod but by suppression of the split into exopod and endopod. Our results offer a developmental approach to discriminate between the different kinds of branches of arthropod appendages. This leads to the conclusion that a ‘true’ biramous limb comprising an endopod and an exopod might have occurred much later in euarthropod evolution than has previously been thought, probably either in the lineage of the Mandibulata or that of the Tetraconata.

scholarly journals Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation

2020 ◽  
Vol 2 (12) ◽  
pp. 1443-1458
Author(s):  
Chen Weng ◽  
Jiajia Xi ◽  
Haiyan Li ◽  
Jian Cui ◽  
Anniya Gu ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Beta Cell ◽  
Single Cell ◽  
Transcriptional Control ◽  
Cell Lineage ◽  
Lineage Analysis

scholarly journals Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

2006 ◽  
Vol 54 (4) ◽  
pp. 1209-1221 ◽  
Author(s):  
Cosimo De Bari ◽  
Francesco Dell'Accio ◽  
Johan Vanlauwe ◽  
Jeroen Eyckmans ◽  
Ilyas M. Khan ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Lineage ◽  
Adult Human ◽  
Periosteal Cells ◽  
Lineage Analysis

scholarly journals Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

2021 ◽  
Author(s):  
Natalia Alkon ◽  
Wolfgang Bauer ◽  
Thomas Krausgruber ◽  
Issac Goh ◽  
Johannes Griss ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Single Cell ◽  
Lymphoid Cell ◽  
Single Cell Analysis ◽  
Cell Lineage ◽  
Cell Analysis ◽  
Innate Lymphoid Cell ◽  
Lineage Infidelity

Major sex-determining genes and the control of sexual dimorphism in Caenorhabditis elegans

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 625-637 ◽  
Author(s):  
Jonathan Hodgkin ◽  
Andrew D. Chisholm ◽  
Michael M. Shen
Keyword(s):  
Caenorhabditis Elegans ◽  
Sex Determination ◽  
X Chromosome ◽  
Germ Line ◽  
Cell Lineage ◽  
Regulatory Genes ◽  
Nematode Caenorhabditis Elegans ◽  
X Chromosomes ◽  
The Many ◽  
Lineage Analysis

Sex determination in Caenorhabditis elegans involves a cascade of major regulatory genes connecting the primary sex determining signal, X chromosome dosage, to key switch genes, which in turn direct development along either male or female pathways. Animals with one X chromosome (XO) are male, while animals with two X chromosomes (XX) are hermaphrodite: hermaphrodite development occurs because the action of the regulatory genes is modified in the germ line so that both sperm and oocytes are made inside a completely female soma. The regulatory genes are being examined by both genetic and molecular means. We discuss how these major genes, in particular the last switch gene in the cascade, tra-1, might regulate the many different sex-specific events that occur during the development of the hermaphrodite and of the male.Key words: nematode, Caenorhabditis elegans, sex determination, sexual differentiation, cell lineage analysis.

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