Neural Stem Cell Fate Control on Micropatterned Substrates

2017 ◽  
pp. 19-44 ◽  
Author(s):  
Leonora Buzanska ◽  
Marzena Zychowicz ◽  
Ana Ruiz ◽  
François Rossi
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Stem Cell Fate ◽  
Fate Control ◽  
Cell Fate Control

scholarly journals ANALYSIS OF INTRACELLULAR SIGNALING KINETICS PREDICTS PRESENTATION MODES AND TARGETS FOR STEM CELL FATE CONTROL

2005 ◽  
Vol preprint (2007) ◽  
pp. e130
Author(s):  
Alborz Mahdavi ◽  
Ryan E Davey ◽  
Patrick Bhola ◽  
Ting Yin ◽  
Peter W Zandstra
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Intracellular Signaling ◽  
Stem Cell Fate ◽  
Fate Control ◽  
Presentation Modes ◽  
Cell Fate Control

scholarly journals Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

Nano Today ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. 759-784 ◽  
Author(s):  
Weiqiang Chen ◽  
Yue Shao ◽  
Xiang Li ◽  
Gang Zhao ◽  
Jianping Fu
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Control Engineering ◽  
Stem Cell Fate ◽  
Fate Control ◽  
Cell Fate Control

scholarly journals Cell Fate Control by Translation: mRNA Translation Initiation as a Therapeutic Target for Cancer Development and Stem Cell Fate Control

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 665 ◽  
Author(s):  
Hyun-Jung Kim
Keyword(s):  
Protein Synthesis ◽  
Stem Cell ◽  
Cell Fate ◽  
Translation Initiation ◽  
Mrna Translation ◽  
Cancer Development ◽  
Cell Behavior ◽  
Stem Cell Fate ◽  
Fate Control ◽  
Cell Fate Control

Translation of mRNA is an important process that controls cell behavior and gene regulation because proteins are the functional molecules that determine cell types and function. Cancer develops as a result of genetic mutations, which lead to the production of abnormal proteins and the dysregulation of translation, which in turn, leads to aberrant protein synthesis. In addition, the machinery that is involved in protein synthesis plays critical roles in stem cell fate determination. In the current review, recent advances in the understanding of translational control, especially translational initiation in cancer development and stem cell fate control, are described. Therapeutic targets of mRNA translation such as eIF4E, 4EBP, and eIF2, for cancer treatment or stem cell fate regulation are reviewed. Upstream signaling pathways that regulate and affect translation initiation were introduced. It is important to regulate the expression of protein for normal cell behavior and development. mRNA translation initiation is a key step to regulate protein synthesis, therefore, identifying and targeting molecules that are critical for protein synthesis is necessary and beneficial to develop cancer therapeutics and stem cells fate regulation.

Instructions from the Vascular System - Directing Neural Stem Cell Fate in Health and Disease

2014 ◽  
Vol 21 (19) ◽  
pp. 2190-2207 ◽  
Author(s):  
S. Schildge ◽  
C. Bohrer ◽  
S. Pfurr ◽  
K. Mammadzada ◽  
K. Schachtrup ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Vascular System ◽  
Stem Cell Fate ◽  
Health And Disease

scholarly journals The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation

2012 ◽  
Vol 72 (7) ◽  
pp. 1068-1084 ◽  
Author(s):  
Allison M. Bond ◽  
Oneil G. Bhalala ◽  
John A. Kessler
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Bone Morphogenetic Proteins ◽  
Stem Cell Fate
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