Culture and attitudes towards contraception of women in subsistence markets: the role of values and social axioms

Purpose The purpose of this paper is to investigate the effects of culture on attitudes to contraception by rural-based women in a developing economy. Design/methodology/approach Based on data collected from 395 rural women in Eastern Zimbabwe, this study examines the hypothesized relationships between values (resultant conservation, resultant self-enhancement), social axioms (reward for application, social cynicism, religiosity, social complexity, fate control and Ubuntu) and contraceptive attitudes, considering the moderating effects of age and education. Findings Using covariance-based Structural Equation Modelling and Multi-Group Analysis, this study found that resultant self-enhancement, fate control, the reward for application and religiosity significantly relate to attitudes to contraception whilst resultant conservation, social complexity, Ubuntu and social cynicism, did not produce significant correlations. Age and education moderate the significant relationships. Research limitations/implications The study's findings suggest that contraception social marketers, non-governmental organizations and health practitioners should develop marketing strategies to neutralize the negative impact of these beliefs held by rural contraceptive consumers to increase contraceptive awareness and uptake in such subsistence markets. In addition, this study provides empirical evidence on the role of Ubuntu as a new culture construct in African markets. Originality/value Despite being limited to a single developing economy, this paper extends prior research on consumer culture and attitudes on contraception use by exploring the role of values and social axioms, an imperative issue for rural women health and general subsistence market well-being.

The social axioms of populism: Investigating the relationship between culture and populist attitudes

Populism is on the rise with various movements having electoral breakthroughs. Most social-science research on populism has focused primarily on party tactics and rhetoric, and a definition for the term itself; only recently has populism emerged as a psychological construct. We contribute to this growing literature with two studies (n = 456 and n = 5,837) that investigated the cultural worldviews underpinned in populist attitudes. Using the social axioms model, an etic framework for assessing people’s generalized social expectations, we linked populist attitudes to universal dimensions of culture. We found that higher levels of social cynicism and social flexibility, and to a lesser extent, lower levels of fate control and reward for application predicted populist attitudes. These findings indicate that people who endorse populist attitudes, across a range of contexts, are cynical regarding the social world, believe in alternative solutions to social dilemmas, but may also perceive a world that is difficult to control and potentially unfair. The discussion focuses on the cultural forces that may drive or facilitate populist attitudes across context and time.

Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs

Recent single-cell studies have revealed that yeast stress response involves transcription factors that are activated in pulses. However, it remains unclear whether and how these dynamic transcription factors temporally interact to regulate stress survival. Here we show that budding yeast cells can exploit the temporal relationship between paralogous general stress regulators, Msn2 and Msn4, during stress response. We find that individual pulses of Msn2 and Msn4 are largely redundant, and cells can enhance the expression of their shared targets by increasing their temporal divergence. Thus, functional redundancy between these two paralogs is modulated in a dynamic manner to confer fitness advantages for yeast cells, which might feed back to promote the preservation of their redundancy. This evolutionary implication is supported by evidence from Msn2/Msn4 orthologs and analyses of other transcription factor paralogs. Together, we show a cell fate control mechanism through temporal redundancy modulation in yeast, which may represent an evolutionarily important strategy for maintaining functional redundancy between gene duplicates.

Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

During mammalian brain development, neural progenitor cells proliferate extensively but can ensure the production of correct numbers of various types of mature cells by balancing symmetric proliferative versus asymmetric differentiative cell divisions. This process of cell fate determination may be harnessed for developing cancer therapy. Here, we test this idea by targeting KIF20A, a mitotic kinesin crucial for the control of cell division modes, in a genetic model of medulloblastoma (MB) and human MB cells. Inducible Kif20a knockout in both normal and MB-initiating granule neuron progenitors (GNPs) causes early cell cycle exit and precocious neuronal differentiation without causing cytokinesis failure and suppresses the development of Sonic Hedgehog (SHH)-activated MB. Inducible KIF20A knockdown in human MB cells inhibits proliferation both in cultures and in growing tumors. Our results indicate that targeting the fate specification process of nascent daughter cells presents a novel avenue for developing anti-proliferation treatment for malignant brain tumors.

Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond

Ubiquitination, and its control by deubiquitinating enzymes (DUBs), mediates protein stability, function, signaling and cell fate. The ovarian tumor (OTU) family DUB OTULIN (FAM105B) exclusively cleaves linear (Met1-linked) poly-ubiquitin chains and plays important roles in auto-immunity, inflammation and infection. OTULIN regulates Met1-linked ubiquitination downstream of tumor necrosis factor receptor 1 (TNFR1), toll-like receptor (TLR) and nucleotide-binding and oligomerization domain-containing protein 2 (NOD2) receptor activation and interacts with the Met1 ubiquitin-specific linear ubiquitin chain assembly complex (LUBAC) E3 ligase. However, despite extensive research efforts, the receptor and cytosolic roles of OTULIN and the distributions of multiple Met1 ubiquitin-associated E3-DUB complexes in the regulation of cell fate still remain controversial and unclear. Apart from that, novel ubiquitin-independent OTULIN functions have emerged highlighting an even more complex role of OTULIN in cellular homeostasis. For example, OTULIN interferes with endosome-to-plasma membrane trafficking and the OTULIN-related pseudo-DUB OTULINL (FAM105A) resides at the endoplasmic reticulum (ER). Here, we discuss how OTULIN contributes to cell fate control and highlight novel ubiquitin-dependent and -independent functions.

Social axioms and coping strategies: the case of a Greek sample

Social axioms are individual assessments of psychological, social, material and spiritual reality expressed as generalized beliefs or assertions about the relationship between two entities or concepts. This study explores how social axioms are associated with coping styles in a Greek sample composed of students and adults. Previous studies of how social axioms are related to coping styles showed that Social Complexity predicted the coping style of problem solving, Fate Control predicted the strategies of distancing, and Social Cynicism predicted the wishful thinking coping processes. In the present study, the 82 item questionnaire version of the Social Axioms Survey (SAS) was employed, along with the Folkman and Lazarus questionnaire of coping styles adapted in the Greek language. Both questionnaires were administered to a sample of 192 individuals, of 48 men and 144 women, among whom 108 were adults and 84 were university students. The sample was composed by two age groups: young adults-students of age 18-30 years (43.8%) and adults of age 31-59 years (56.3%). The results showed that Social Cynicism was not correlated in any way withcoping strategies; however, Social Complexity was significantly associated with problem solving strategies, and Fate control was also associated with wishful thinking and distancing coping strategies.