RNAi Technique in Stem Cell Research: Current Status and Future Perspectives

2017 ◽  
pp. 3-14 ◽  
Author(s):  
Gang-Ming Zou
Keyword(s):  
Stem Cell ◽  
Stem Cell Research ◽  
Current Status ◽  
Future Perspectives ◽  
Rnai Technique

scholarly journals Mesenchymal stem cell as a novel approach to systemic sclerosis; current status and future perspectives

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Mina Abedi ◽  
Sepideh Alavi-Moghadam ◽  
Moloud Payab ◽  
Parisa Goodarzi ◽  
Fereshteh Mohamadi-jahani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Systemic Sclerosis ◽  
Mesenchymal Stem Cell ◽  
Epidemiological Data ◽  
Current Status ◽  
Future Perspectives ◽  
Mesenchymal Stem Cell Transplantation ◽  
Novel Approach ◽  
Contemporary Status

AbstractSystemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and various internal organs. According to epidemiological data, women’s populations are more susceptible to systemic sclerosis than men. Until now, various therapeutic options are employed to manage the symptoms of the disease. Since stem cell-based treatments have developed as a novel approach to rescue from several autoimmune diseases, it seems that stem cells, especially mesenchymal stem cells as a powerful regenerative tool can also be advantageous for systemic sclerosis treatment via their remarkable properties including immunomodulatory and anti-fibrotic effects. Accordingly, we discuss the contemporary status and future perspectives of mesenchymal stem cell transplantation for systemic sclerosis.

scholarly journals Stem Cells: Therapeutic Potential in Dentistry

2009 ◽  
Vol 10 (4) ◽  
pp. 90-96 ◽  
Author(s):  
Flávio Fernando Demarco ◽  
Dárvi de Almeida André ◽  
Fernanda Nedel ◽  
Isabel Oliveira de Oliveira ◽  
Mabel M. Cordeiro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Research ◽  
Cell Biology ◽  
Therapeutic Potential ◽  
Dental Enamel ◽  
Tissue Loss ◽  
Permanent Teeth ◽  
Current Status ◽  
Pulp Tissue

Abstract Aim The aim of this paper is to present a review and discussion of the current status of stem cell research with regard to tooth generation. Background Stem cells have been isolated from the pulp tissue of both deciduous and permanent teeth as well as from the periodontal ligament. Dental pulp stem cells demonstrate the capacity to form a dentin pulp-like complex in immunocompromised mice. A tooth-like structure was successfully formed, using a heterogeneous mixture of dental enamel epithelium, pulp mesenchymal cells, and scaffolds. Conclusion The scientific community understands the need for more investigations to completely understand the conditions that would best favor the creation of a tooth substitute. Recent gains in the understanding of the molecular regulation of tooth morphogenesis, stem cell biology, and biotechnology offers the opportunity to realize this goal. Clinical Significance These findings, combined with the recent progress in stem cell research and tissue engineering, might allow the development of alternatives for current materials and therapies used to treat tooth tissue loss (e.g., enamel, dentin, pulp), reconstruct dentoalveolar and craniofacial bone defects, and eventually replace an entire tooth. Citation Nedel F, André DA, Oliveira IO, Cordeiro MM, Casagrande L, Tarquinio SBC, Nor JE, Demarco FF. Stem Cells: Therapeutic Potential in Dentistry. J Contemp Dent Pract 2009 July; (10)4:090-096.

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