Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension

2017 ◽  
pp. 91-116 ◽  
Author(s):  
Sabine Klein ◽  
Robert Schierwagen ◽  
Frank Erhard Uschner ◽  
Jonel Trebicka
Keyword(s):  
Portal Hypertension ◽  
Hepatic Fibrosis ◽  
Rat Models

Congenital hepatic fibrosis of Riedel's lobe causing portal hypertension: Report of a Case

1969 ◽  
Vol 36 (3) ◽  
pp. 143-148 ◽  
Author(s):  
R. G. Farmer ◽  
R. E. Hermann ◽  
B. H. Sullivan
Keyword(s):  
Portal Hypertension ◽  
Hepatic Fibrosis ◽  
Congenital Hepatic Fibrosis

1001 THE CLINICAL VALUE OF ENDOSCOPIC ULTRASOUND GUIDED PORTAL PRESSURE GRADIENT MEASUREMENT IN DIAGNOSING PORTAL HYPERTENSION AND STAGING HEPATIC FIBROSIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-1300-S-1301
Author(s):  
Alyssa Y. Choi ◽  
Xiadong Li ◽  
Wenchang Guo ◽  
Vishal S. Chandan ◽  
Jason Samarasena ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Pressure Gradient ◽  
Hepatic Fibrosis ◽  
Endoscopic Ultrasound ◽  
Portal Pressure ◽  
Ultrasound Guided ◽  
Clinical Value ◽  
Gradient Measurement

scholarly journals Mechanism of Fibrosis Induced by Echinococcus spp.

Diseases ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 51 ◽  
Author(s):  
Niu ◽  
Chong ◽  
Qin ◽  
Li ◽  
Wei ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Hepatic Fibrosis ◽  
Review Paper ◽  
Normal Liver ◽  
Pathological Feature ◽  
Human Beings ◽  
Lesion Site ◽  
Intermediate Hosts ◽  
Antiparasitic Drugs ◽  
Echinococcus Spp

Infection with Echinococcus spp. causes fibrosis in various vital organs, including the liver and lungs. Hepatic fibrosis is a pathological feature of Echinococcus infection that destroys normal liver tissue, leading to jaundice, cholecystitis, portal hypertension, etc. Severe Echinococcus multilocularis infections lead to liver failure and hepatic encephalopathy. The formation of peripheral fiberboards around the metacestode is a major reason as to why antiparasitic drugs fail to be effectively transported to the lesion site. Studies on the mechanism of hepatic fibrosis caused by Echinococcus are important for treatment in patients. Recent studies have focused on miRNA and TGF-β. More recent findings have focused on the generation of collagen fibers around the metacestode. In this review paper we focus on the mechanism by which the Echinococcus parasite induces fibrosis in liver and some other organs in intermediate hosts—animals as well as human beings.

scholarly journals Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease

2020 ◽  
Author(s):  
Zoe Boyer-Diaz ◽  
Peio Aristu-Zabalza ◽  
María Andrés-Rozas ◽  
Claude Robert ◽  
Martí Ortega-Ribera ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Hepatic Fibrosis ◽  
Chronic Liver ◽  
Ppar Agonist

scholarly journals Its Congenital Hepatic Fibrosis; Not Cirrhosis At All

2018 ◽  
Vol 1 (2) ◽  
pp. 124-126
Author(s):  
Ananta Shrestha ◽  
Mamun Al-Mahtab ◽  
Salimur Rahman ◽  
Jahangir Sarkar ◽  
Thupten K Lama
Keyword(s):  
Portal Hypertension ◽  
Hepatic Fibrosis ◽  
Autosomal Recessive ◽  
Rare Condition ◽  
Recessive Trait ◽  
Congenital Hepatic Fibrosis ◽  
Life Threatening ◽  
Hepatic Histology ◽  
Upper Abdomen ◽  
Medical University

Congenital hepatic fibrosis is a rare condition characterized by extensive fibrosis of liver but with preserved normal lobular architecture inherited as autosomal recessive trait. We report a 19 year-old-female admitted to Bangabandhu Sheikh Mujib Medical University with the complaints of lump in upper abdomen since last 13 years and episodes of fever and abdominal pain for same duration. She was diagnosed with hepatic TB on hepatic histology. Congenital hepatic fibrosis is a rare cause of portal hypertension that presents during childhood. Prognosis of congenital hepatic fibrosis is good. Life threatening events in these patients are related with variceal bleeding and episodes of cholangitis. Owing to relatively good liver function these patients tolerate portosystemic shunt surgeries quite well.Though rare, congenital hepatic fibrosis should be included in the differential diagnosis of portal hypertension in early life.

Arterial hypoxemia and intrapulmonary vasodilatation in rat models of portal hypertension

2005 ◽  
Vol 40 (8) ◽  
pp. 811-819 ◽  
Author(s):  
Yasumi Katsuta ◽  
Xue-Jun Zhang ◽  
Masaru Ohsuga ◽  
Toshio Akimoto ◽  
Hirokazu Komeichi ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Rat Models ◽  
Arterial Hypoxemia

Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats

2009 ◽  
Vol 297 (4) ◽  
pp. G762-G767 ◽  
Author(s):  
William Kemp ◽  
Andrew Kompa ◽  
Arintaya Phrommintikul ◽  
Chandana Herath ◽  
Jia Zhiyuan ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Growth Factor ◽  
Hepatic Fibrosis ◽  
Transforming Growth Factor ◽  
Venous Pressure ◽  
Portal Pressure ◽  
Hepatic Tissue ◽  
High Dose ◽  
Urotensin Ii

The influence of circulating urotensin II (UII) on liver disease and portal hypertension is unknown. We aimed to evaluate whether UII executes a pathogenetic role in the development of hepatic fibrosis and portal hypertension. UII was administered by continuous infusion over 4 wk in 20 healthy rats divided into three treatment groups, controls (saline, n = 7), low dose (UII, 1 nmol·kg−1·h−1, n = 8), and high dose (UII, 3 nmol·kg−1·h−1, n = 5). Hemodynamic parameters and morphometric quantification of fibrosis were assessed, and profibrotic cytokines and fibrosis markers were assayed in hepatic tissue. UII induced a significant dose-dependent increase in portal venous pressure (5.8 ± 0.4, 6.4 ± 0.3, and 7.6 ± 0.7, respectively, P = 0.03). High-dose UII infusion was associated with an increase in hepatic transcript for transforming growth factor-β ( P < 0.05) and platelet-derived growth factor-β ( P = 0.06). Liver tissue hydroxyproline was elevated in the high-dose group ( P < 0.05). No systemic hemodynamic alterations were noted. We concluded that UII infusion elevates portal pressure and induces hepatic fibrosis in normal rats. This response may be mediated via induction of fibrogenic cytokines. These findings have pathophysiological implications in human liver disease where increased plasma UII levels have been observed.

scholarly journals Congenital Hepatic Fibrosis and Portal Hypertension in Autosomal Dominant Polycystic Kidney Disease

2012 ◽  
Vol 54 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Kevin O’Brien ◽  
Esperanza Font-Montgomery ◽  
Linda Lukose ◽  
Joy Bryant ◽  
Katie Piwnica-Worms ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Hepatic Fibrosis ◽  
Autosomal Dominant ◽  
Congenital Hepatic Fibrosis ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney
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