Bioinformatics Pipeline for Accurate Quantification of Fetal DNA Fraction in Maternal Plasma

2018 ◽  
pp. 177-180
Author(s):  
Meng Ni ◽  
Xianlu Laura Peng ◽  
Peiyong Jiang
Keyword(s):  
Maternal Plasma ◽  
Bioinformatics Pipeline ◽  
Fetal Dna ◽  
Accurate Quantification

scholarly journals FetalQuantSD: accurate quantification of fetal DNA fraction by shallow-depth sequencing of maternal plasma DNA

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Peiyong Jiang ◽  
Xianlu Peng ◽  
Xiaoxi Su ◽  
Kun Sun ◽  
Stephanie C Y Yu ◽  
...  
Keyword(s):  
Maternal Plasma ◽  
Shallow Depth ◽  
Plasma Dna ◽  
Fetal Dna ◽  
Accurate Quantification

582: Early prediction of fetal gender by using free fetal DNA from maternal plasma

2008 ◽  
Vol 199 (6) ◽  
pp. S169
Author(s):  
Gian Carlo Di Renzo ◽  
Elena Picchiassi ◽  
Alessia Fanetti ◽  
Michela Centra ◽  
Graziano Clerici ◽  
...  
Keyword(s):  
Maternal Plasma ◽  
Early Prediction ◽  
Fetal Dna ◽  
Fetal Gender

Placental volume and cell-free fetal DNA levels in maternal plasma between 15 and 18 gestational weeks

2006 ◽  
Vol 195 (6) ◽  
pp. S174
Author(s):  
Donghyun Cha ◽  
Kyoungjin Lee ◽  
Ji Hyun Park ◽  
Kyoung Joo Lee ◽  
Ji Yeon Kim ◽  
...  
Keyword(s):  
Maternal Plasma ◽  
Fetal Dna ◽  
Cell Free Fetal Dna ◽  
Placental Volume

scholarly journals Impact of Formaldehyde on the in Vitro Proportion of Fetal DNA in Maternal Plasma and Serum

2005 ◽  
Vol 51 (1) ◽  
pp. 242-244 ◽  
Author(s):  
Alexandra Benachi ◽  
Amina Yamgnane ◽  
Martine Olivi ◽  
Yves Dumez ◽  
Evelyne Gautier ◽  
...  
Keyword(s):  
Maternal Plasma ◽  
Fetal Dna

scholarly journals Size Distributions of Maternal and Fetal DNA in Maternal Plasma

2004 ◽  
Vol 50 (1) ◽  
pp. 88-92 ◽  
Author(s):  
K C Allen Chan ◽  
Jun Zhang ◽  
Angela B Y Hui ◽  
Nathalie Wong ◽  
Tze K Lau ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Size Distribution ◽  
Maternal Plasma ◽  
Rapid Expansion ◽  
Molecular Characteristics ◽  
Dna Fragments ◽  
Dna Molecules ◽  
Plasma Dna ◽  
Fetal Dna ◽  
Noninvasive Prenatal Diagnosis

Abstract Background: The discovery of fetal DNA in maternal plasma has opened up an approach for noninvasive prenatal diagnosis. Despite the rapid expansion in clinical applications, the molecular characteristics of plasma DNA in pregnant women remain unclear. Methods: We investigated the size distribution of plasma DNA in 34 nonpregnant women and 31 pregnant women, using a panel of quantitative PCR assays with different amplicon sizes targeting the leptin gene. We also determined the size distribution of fetal DNA in maternal plasma by targeting the SRY gene. Results: The median percentages of plasma DNA with size >201 bp were 57% and 14% for pregnant and nonpregnant women, respectively (P <0.001, Mann–Whitney test). The median percentages of fetal-derived DNA with sizes >193 bp and >313 bp were 20% and 0%, respectively, in maternal plasma. Conclusion: Plasma DNA molecules are mainly short DNA fragments. The DNA fragments in the plasma of pregnant women are significantly longer than those in the plasma of nonpregnant women, and the maternal-derived DNA molecules are longer than the fetal-derived ones.

No evidence of fetal DNA persistence in maternal plasma after pregnancy

2003 ◽  
Vol 112 (5-6) ◽  
pp. 617-618 ◽  
Author(s):  
Maddalena Smid ◽  
Silvia Galbiati ◽  
Antonia Vassallo ◽  
Dania Gambini ◽  
Augusto Ferrari ◽  
...  
Keyword(s):  
Maternal Plasma ◽  
Fetal Dna
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