Exogenous Carcinogen-DNA Adducts and Their Repair in Mammalian Cells

1998 ◽  
pp. 51-64
Author(s):  
Anthony Dipple ◽  
Leonora J. Lipinski
Keyword(s):  
Dna Adducts ◽  
Mammalian Cells

Mutagenic Specificity of (Acetylamino)fluorene-Derived DNA Adducts in Mammalian Cells†

Biochemistry ◽  
1998 ◽  
Vol 37 (35) ◽  
pp. 12034-12041 ◽  
Author(s):  
Shinya Shibutani ◽  
Naomi Suzuki ◽  
Arthur P. Grollman
Keyword(s):  
Dna Adducts ◽  
Mammalian Cells

Exogenous Carcinogen-DNA Adducts and Their Repair in Mammalian Cells

2003 ◽  
pp. 51-64
Author(s):  
Anthony Dipple ◽  
Leonora J. Lipinski
Keyword(s):  
Dna Adducts ◽  
Mammalian Cells

Mutagenic Specificity of Model Estrogen−DNA Adducts in Mammalian Cells†

Biochemistry ◽  
1998 ◽  
Vol 37 (24) ◽  
pp. 8803-8807 ◽  
Author(s):  
Isamu Terashima ◽  
Naomi Suzuki ◽  
Shinji Itoh ◽  
Itsuo Yoshizawa ◽  
Shinya Shibutani
Keyword(s):  
Dna Adducts ◽  
Mammalian Cells

Arsenite induces oxidative DNA adducts and DNA-protein cross-links in mammalian cells

2001 ◽  
Vol 31 (3) ◽  
pp. 321-330 ◽  
Author(s):  
Tsu-Shing Wang ◽  
Tsung-Yang Hsu ◽  
Chiao-Hui Chung ◽  
Alexander S.S Wang ◽  
Da-Tian Bau ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Mammalian Cells ◽  
Cross Links

Mutagenic potential of DNA adducts formed by diol-epoxides, triol-epoxides and the K-region epoxide of chrysene in mammalian cells

1986 ◽  
Vol 7 (10) ◽  
pp. 1739-1743 ◽  
Author(s):  
D.H. Phillips ◽  
H.R. Glatt ◽  
A. Seidel ◽  
W. Bochnitschek ◽  
F. Oesch ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Mammalian Cells ◽  
Mutagenic Potential ◽  
Diol Epoxides

scholarly journals Quantitative detection of 4-hydroxyequilenin-DNA adducts in mammalian cells using an immunoassay with a novel monoclonal antibody

2010 ◽  
Vol 38 (12) ◽  
pp. e133-e133 ◽  
Author(s):  
Y. Okahashi ◽  
T. Iwamoto ◽  
N. Suzuki ◽  
S. Shibutani ◽  
S. Sugiura ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Dna Adducts ◽  
Mammalian Cells ◽  
Quantitative Detection

scholarly journals PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Ann Liza Piberger ◽  
Akhil Bowry ◽  
Richard D. W. Kelly ◽  
Alexandra K. Walker ◽  
Daniel González-Acosta ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Dna Adducts ◽  
Mammalian Cells ◽  
Genetic Recombination ◽  
Gap Formation ◽  
Dna Damage Tolerance ◽  
Strand Breaks ◽  
Bulky Dna Adducts ◽  
Fork Stalling ◽  
Stalled Replication Forks

AbstractStalled replication forks can be restarted and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle. Bulky DNA adducts are important replication-blocking lesions, but it is unknown whether they activate HR at stalled forks or behind ongoing forks. Using mainly BPDE-DNA adducts as model lesions, we show that HR induced by bulky adducts in mammalian cells predominantly occurs at post-replicative gaps formed by the DNA/RNA primase PrimPol. RAD51 recruitment under these conditions does not result from fork stalling, but rather occurs at gaps formed by PrimPol re-priming and resection by MRE11 and EXO1. In contrast, RAD51 loading at double-strand breaks does not require PrimPol. At bulky adducts, PrimPol promotes sister chromatid exchange and genetic recombination. Our data support that HR at bulky adducts in mammalian cells involves post-replicative gap repair and define a role for PrimPol in HR-mediated DNA damage tolerance.

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