Applicator and Electrode Design for In Vivo DNA Delivery by Electroporation

2008 ◽  
pp. 35-59 ◽  
Author(s):  
Dietmar Rabussay
Keyword(s):  
Dna Delivery ◽  
Electrode Design

scholarly journals Synthetic DNA Delivery by Electroporation Promotes Robust in Vivo Sulfation of Broadly Neutralizing Anti-HIV Immunoadhesin eCD4-Ig

2018 ◽  
Author(s):  
Ziyang Xu ◽  
Megan C. Wise ◽  
Hyeree Choi ◽  
Alfredo Perales-Puchalt ◽  
Ami Patel ◽  
...  
Keyword(s):  
Dna Delivery ◽  
Synthetic Dna ◽  
Anti Hiv

DNA Delivery to Cells In Vivo by Ultrasound

2004 ◽  
pp. 293-298
Author(s):  
Thomas P. McCreery ◽  
Robert H. Sweitzer ◽  
Evan C. Unger ◽  
Sean Sullivan
Keyword(s):  
Dna Delivery

scholarly journals A New Broad Range Plasmid for DNA Delivery in Eukaryotic Cells Using Lactic Acid Bacteria: In Vitro and In Vivo Assays

2017 ◽  
Vol 4 ◽  
pp. 83-91 ◽  
Author(s):  
Pamela Mancha-Agresti ◽  
Mariana Martins Drumond ◽  
Fillipe Luiz Rosa do Carmo ◽  
Monica Morais Santos ◽  
Janete Soares Coelho dos Santos ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Dna Delivery ◽  
Eukaryotic Cells ◽  
In Vivo Assays

scholarly journals In Vivo Analysis of Glucocorticoid-Induced Reporter Gene Expression Using Gene Gun DNA Delivery

2002 ◽  
Vol 25 (8) ◽  
pp. 1115-1118 ◽  
Author(s):  
Kiyoshi Tanigawa ◽  
Katsunao Tanaka ◽  
Hidetaka Nagase ◽  
Hidekazu Miyake ◽  
Mamoru Kiniwa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reporter Gene ◽  
Dna Delivery ◽  
Reporter Gene Expression ◽  
Gene Gun ◽  
In Vivo Analysis

scholarly journals Complex Coacervation-Integrated Hybrid Nanoparticles Increasing Plasmid DNA Delivery Efficiency in Vivo

2016 ◽  
Vol 8 (45) ◽  
pp. 30735-30746 ◽  
Author(s):  
Yunfei Li ◽  
Brock Humphries ◽  
Zhishan Wang ◽  
Shuyao Lang ◽  
Xuefei Huang ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Dna Delivery ◽  
Hybrid Nanoparticles ◽  
Complex Coacervation ◽  
Delivery Efficiency

In Vivo Gene Gun-Mediated DNA Delivery into Rodent Brain Tissue

2000 ◽  
Vol 270 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Hidemitsu Sato ◽  
Satoshi Hattori ◽  
Susumu Kawamoto ◽  
Ichidai Kudoh ◽  
Akimune Hayashi ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Dna Delivery ◽  
Gene Gun ◽  
Rodent Brain

Liver-directed gene transfer: a linear polyethylenimine derivative mediates highly efficient DNA delivery to primary hepatocytes in vitro and in vivo

1998 ◽  
Vol 5 (6) ◽  
pp. 369-375 ◽  
Author(s):  
I. Chemin ◽  
D. Moradpour ◽  
S. Wieland ◽  
W. -B. Offensperger ◽  
E. Walter ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Dna Delivery ◽  
Primary Hepatocytes ◽  
Highly Efficient ◽  
Linear Polyethylenimine

NANOMEDICINES: DELIVERING DRUGS USING BOTTOM UP NANOTECHNOLOGY

2005 ◽  
Vol 04 (05n06) ◽  
pp. 855-861 ◽  
Author(s):  
MARTIN GARNETT
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Biodegradable Polymers ◽  
Drug Loading ◽  
Dna Delivery ◽  
Delivery Systems ◽  
The Body ◽  
Nanosized Materials

The use of nanosized materials changes the way in which drugs are handled by the body and offers opportunities to improve drug delivery. The physiological mechanisms controlling the distribution of nanosized materials (enhanced permeability and retention effect, cellular uptake pathways and opsonisation/elimination of nanoparticles) are described. Two different nanosized drug delivery systems are considered; drug delivery and DNA delivery. The deficiencies of currently available biodegradable polymers for preparation of drug containing nanoparticles are mainly the amount of drug that can be incorporated and the rapid rate of drug release. The development of new biodegradable polymers which can interact with the drug and so significantly increase drug loading and decrease the rate of drug release are outlined. DNA delivery necessitates overcoming a variety of biological barriers. We are developing polyelectrolyte complexes of DNA with cationic polyamidoamines (PAA) as a delivery system. Complexing PAA with DNA results in good transfection of cells in vitro. However, in vivo, a more complex arrangement of PAA, Polyethylene glycol-PAA copolymers, DNA and the use of ligands will be required. Despite these efforts, further developments will be needed in nanotechnology for both drug and DNA nanoparticle delivery systems to achieve our clinical objectives.

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