Neuroendocrine Tumors of Prostate, Urinary Bladder and Kidney

Author(s):  
Zhong Jiang
2017 ◽  
Vol 03 (02) ◽  
pp. 144-146
Author(s):  
Jatin Sundersham Gandhi ◽  
Sunil Pasricha ◽  
Gurudutt Gupta

AbstractLarge cell neuroendocrine tumors of the bladder are rare tumors. Their co-association with adenocarcinoma is even rarer. We present a third undisputed case of collision tumor comprising large cell neuroendocrine carcinoma and adenocarcinoma of the urinary bladder in a 73-year-old gentleman with a revisit to its origin and histogenesis.


2013 ◽  
Vol 20 (06) ◽  
pp. 929-931
Author(s):  
MALIK HUSSAIN JALBANI ◽  
NISAR AHMED SHAIKH ◽  
GHULAM SHABIR SHAIKH

Objective: To evaluate clinical presentation and surgical out come of primary neuroendocrine tumors of Kidney, U. bladderand Prostate gland. Design: A Retrospective study. Setting: Urology Department, SMBBMU Larkana. Period: 2001-2011. Patients andMethods: Series of 6 patients of primary neuroendocrine tumors of Kidney, U. bladder and Prostate gland were identified from 1890cases of urinary tract tumors. Two cases of renal carcinoid, two cases of small cell carcinoma of urinary bladder and two cases of smallcell carcinoma of prostate glands. Renal carcinoid tumors presenting with lumbar pain and microscopic haematuria and identified on theultrasound. Small cell carcinoma of urinary bladder presenting with dysuria, gross haematuria and on ultrasound while small cellcarcinoma of prostate gland presenting with irritatory and obstructive symptoms and confirmed on DRE. Results: 6 patients(5 male and1 female),Mean age of patients were 45years and range was 35-55 years. All patients treated primarily by definitive surgery like RadicalNephrectomy, TURBT and Pallitive TURP and all tumors confirmed on histopathological examination and referred to LINAR Larkana forproper managements. Conclusions: primary neuroendocrine tumors of Kidney, U.bladder and Prostate gland are rare tumors. Carcinoidtumors have good prognosis but small cell carcinoma have poor prognosis so require prompt treatment.


2021 ◽  
pp. 113-128
Author(s):  
Ahmed N. Shehabeldin ◽  
Jae Y. Ro

2016 ◽  
Vol 2 (1) ◽  
pp. 42-49
Author(s):  
Monika Ulamec ◽  
◽  
Božo Krušlin

2021 ◽  
Vol 11 ◽  
pp. e2021305
Author(s):  
Meenakshi Rao ◽  
Apoorvi Dubey ◽  
Himanshu Pandey ◽  
Binit Sureka ◽  
Pawan Kumar Garg ◽  
...  

2019 ◽  
Vol 11 (01) ◽  
pp. 091-093
Author(s):  
Manjari Kishore ◽  
Purnima Malhotra ◽  
Minakshi Bhardwaj

AbstractNeuroendocrine tumors (NETs) are commonly located in the respiratory and gastrointestinal tract; however, these tumors can rarely be found in the urinary bladder. NETs comprise <1% of all bladder tumors; usually intermixed with urothelial carcinoma and its variants. We report a case of primary neuroendocrine carcinoma of urinary bladder in an adult female with a history of smoking and hematuria. The present case highlights the importance of immunohistochemistry in arriving at an accurate diagnosis and thereby differentiating this tumor from other clinical mimics.


Author(s):  
A.J. Mia ◽  
L.X. Oakford ◽  
T. Yorio

The amphibian urinary bladder has been used as a ‘model’ system for studies of the mechanism of action of antidiuretic hormone (ADH) in stimulating transepithelial water flow. The increase in water permeability is accompanied by morphological changes that include the stimulation of apical microvilli, mobilization of microtubules and microfilaments and vesicular membrane fusion events . It has been shown that alterations in the cytosolic calcium concentrations can inhibit ADH transmembrane water flow and induce alterations in the epithelial cell cytomorphology, including the cytoskeletal system . Recently, the subapical granules of the granular cell in the amphibian urinary bladder have been shown to contain high concentrations of calcium, and it was suggested that these cytoplasmic constituents may act as calcium storage sites for intracellular calcium homeostasis. The present study utilizes the calcium antagonist, verapamil, to examine the effect of calcium deprivation on the cytomorphological features of epithelial cells from amphibian urinary bladder, with particular emphasis on subapical granule and microfilament distribution.


Author(s):  
A.J. Mia ◽  
L.X. Oakford ◽  
T. Yorio

Protein kinase C (PKC) isozymes, when activated, are translocated to particulate membrane fractions for transport to the apical membrane surface in a variety of cell types. Evidence of PKC translocation was demonstrated in human megakaryoblastic leukemic cells, and in cardiac myocytes and fibroblasts, using FTTC immunofluorescent antibody labeling techniques. Recently, we reported immunogold localizations of PKC subtypes I and II in toad urinary bladder epithelia, following 60 min stimulation with Mezerein (MZ), a PKC activator, or antidiuretic hormone (ADH). Localization of isozyme subtypes I and n was carried out in separate grids using specific monoclonal antibodies with subsequent labeling with 20nm protein A-gold probes. Each PKC subtype was found to be distributed singularly and in discrete isolated patches in the cytosol as well as in the apical membrane domains. To determine if the PKC isozymes co-localized within the cell, a double immunogold labeling technique using single grids was utilized.


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