Identification of a Common Variant Affecting Human Episodic Memory Performance Using a Pooled Genome-Wide Association Approach: A Case Study of Disease Gene Identification

2010 ◽  
pp. 261-269 ◽  
Author(s):  
Traci L. Pawlowski ◽  
Matthew J. Huentelman
Keyword(s):  
Episodic Memory ◽  
Disease Gene ◽  
Memory Performance ◽  
Common Variant ◽  
Genome Wide Association ◽  
Gene Identification ◽  
Genome Wide

scholarly journals Impacts of Population Structure and Analytical Models in Genome-Wide Association Studies of Complex Traits in Forest Trees: A Case Study in Eucalyptus globulus

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e81267 ◽  
Author(s):  
Eduardo P. Cappa ◽  
Yousry A. El-Kassaby ◽  
Martín N. Garcia ◽  
Cintia Acuña ◽  
Nuno M. G. Borralho ◽  
...  
Keyword(s):  
Population Structure ◽  
Complex Traits ◽  
Eucalyptus Globulus ◽  
Association Studies ◽  
Genome Wide Association ◽  
Analytical Models ◽  
Genome Wide Association Studies ◽  
Forest Trees ◽  
Genome Wide

scholarly journals O1-01-02: Genome-wide association study of memory performance

2011 ◽  
Vol 7 ◽  
pp. S93-S93
Author(s):  
Stéphanie Debette ◽  
Helena Schmidt ◽  
James Wilson ◽  
Velandai Srikanth ◽  
Lina Zgaga ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Memory Performance ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals A genome-wide association study identifies RNF213 as the first Moyamoya disease gene

2010 ◽  
Vol 56 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Fumiaki Kamada ◽  
Yoko Aoki ◽  
Ayumi Narisawa ◽  
Yu Abe ◽  
Shoko Komatsuzaki ◽  
...  
Keyword(s):  
Association Study ◽  
Moyamoya Disease ◽  
Genome Wide Association Study ◽  
Disease Gene ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

How to discover a metabolic pathway? An update on gene identification in aliphatic glucosinolate biosynthesis, regulation and transport

2014 ◽  
Vol 395 (5) ◽  
pp. 529-543 ◽  
Author(s):  
Lea Møller Jensen ◽  
Barbara Ann Halkier ◽  
Meike Burow
Keyword(s):  
Association Studies ◽  
Phylogenetic Analyses ◽  
Lessons Learned ◽  
Genome Wide Association ◽  
Gene Identification ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Aliphatic Glucosinolates ◽  
Biosynthesis Regulation

Abstract Identification of enzymes, regulators and transporters involved in different metabolic processes is the foundation to understand how organisms function. There are, however, many difficulties in identifying candidate genes as well as in proving their in vivo roles. In this review, we describe different approaches utilized in Arabidopsis thaliana to identify gene candidates and experiments required to prove the function of a given candidate. For example, we use the production of methionine-derived aliphatic glucosinolates that represent major defence compounds in A. thaliana. Nearly all biosynthetic genes, as well as the first sets of regulators and transporters, have been identified. An array of approaches, i.e. classical mapping, quantitative trait loci (QTL) mapping, eQTL mapping, co-expression, genome wide association studies (GWAS), mutant screens and phylogenetic analyses, has been exploited to increase the number of identified genes. Here we summarize the lessons learned from the different approaches used over the years with the aim to help designing and combining new approaches in the future.

P1-264: A Genome-Wide Association Scan for Episodic Memory Decline in Aging

2011 ◽  
Vol 7 ◽  
pp. S195-S195
Author(s):  
Joshua Shulman ◽  
Lori Chibnik ◽  
Brendan Keenan ◽  
Anita Destefano ◽  
Sue Leurgans ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Genome Wide Association ◽  
Memory Decline ◽  
Genome Wide ◽  
A Genome
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