Electrophysiological Analysis of the Modulation of NMDA-Receptors Function by d-Serine and Glycine in the Central Nervous System

2011 ◽  
pp. 299-312 ◽  
Author(s):  
Fabrice Turpin ◽  
Glenn Dallérac ◽  
Jean-Pierre Mothet
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nmda Receptors ◽  
Electrophysiological Analysis ◽  
The Central Nervous System

The regulation of NMDA receptors in the central nervous system

1989 ◽  
Vol 13 (3-4) ◽  
pp. 481-488 ◽  
Author(s):  
John F. Macdonald ◽  
Istvan Mody ◽  
Michael W. Salter ◽  
Peter Pennefather ◽  
Jacob H. Schneiderman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nmda Receptors ◽  
The Central Nervous System

scholarly journals Effects of Riluzole on Nr2B subunits of NMDA receptors in rat migraine model

2019 ◽  
Vol 10 (3) ◽  
pp. 2242-2245
Author(s):  
Sankaran PK ◽  
Gunapriya Raghunath ◽  
Joy Ghoshal ◽  
Yuvaraj Maria Francis ◽  
Siva T ◽  
...  
Keyword(s):  
Public Health ◽  
Central Nervous System ◽  
Nervous System ◽  
Nmda Receptors ◽  
Sensory Neurons ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Intense Staining ◽  
Nerve Ganglion ◽  
The Central Nervous System

Migraine, a major public health problem, occurring due to the consequences of serial changes in the nerve ganglion leading to an imbalance in the excitation and inhibition. The is the major neurotransmitter in the central nervous system, causing to the sensory neurons leading to sensitization and . The present study was done to determine the effects of on the Nr2B of NMDA receptors after inducing a migraine. The rats were treated with after inducing migraine with nitroglycerin 10mg/kg. The nitroglycerin treated rats showed intense staining for NR2B , and there was a decrease in the expression after treatment. This study concludes that the NR2B are during migraine and can be used to control those by its property.

scholarly journals NMDA Receptors in the Central Nervous System

2017 ◽  
pp. 1-80 ◽  
Author(s):  
Kasper B. Hansen ◽  
Feng Yi ◽  
Riley E. Perszyk ◽  
Frank S. Menniti ◽  
Stephen F. Traynelis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nmda Receptors ◽  
The Central Nervous System

scholarly journals D-Amino Acids in the Nervous and Endocrine Systems

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Yoshimitsu Kiriyama ◽  
Hiromi Nochi
Keyword(s):  
Amino Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Nmda Receptors ◽  
Disulfide Bonds ◽  
Endocrine System ◽  
Hormone Release ◽  
Endocrine Organs ◽  
The Central Nervous System ◽  
Lateral Sclerosis

Amino acids are important components for peptides and proteins and act as signal transmitters. Only L-amino acids have been considered necessary in mammals, including humans. However, diverse D-amino acids, such as D-serine, D-aspartate, D-alanine, and D-cysteine, are found in mammals. Physiological roles of these D-amino acids not only in the nervous system but also in the endocrine system are being gradually revealed. N-Methyl-D-aspartate (NMDA) receptors are associated with learning and memory. D-Serine, D-aspartate, and D-alanine can all bind to NMDA receptors. H2S generated from D-cysteine reduces disulfide bonds in receptors and potentiates their activity. Aberrant receptor activity is related to diseases of the central nervous system (CNS), such as Alzheimer’s disease, amyotrophic lateral sclerosis, and schizophrenia. Furthermore, D-amino acids are detected in parts of the endocrine system, such as the pineal gland, hypothalamus, pituitary gland, pancreas, adrenal gland, and testis. D-Aspartate is being investigated for the regulation of hormone release from various endocrine organs. Here we focused on recent findings regarding the synthesis and physiological functions of D-amino acids in the nervous and endocrine systems.

Sign in / Sign up

Export Citation Format

Share Document