A RETROPERITONEAL SEMINOMA WITH ENTRAPPED NERVE GANGLION MASQUERADING AS A PARAGANGLIOMA

Objective: The differential diagnosis of retroperito-neal tumors includes lymphoid, germ cell, and neurogenic tumors such as paraganglioma. Paragangliomas are rare neuroendocrine tumors of the autonomic nervous system, which may secrete catecholamines and their metabolites. Clinical features include sustained or paroxysmal hypertension, headaches, sweating, and palpitations. Here we present an unusual case of a retroperitoneal tumor entrapping a sympathetic nerve ganglion and mimicking paraganglioma.Methods: A 57-year-old man with a history of controlled hypertension presented with paroxysms of tachycardia, flushing, high blood pressure, and headache. Ambulatory blood pressure monitoring showed uncontrolled labile hypertension with a normal nocturnal dip. Abdominal computed tomography (CT) demonstrated a 6.1 cm mass in the right retroperitoneum with adjacent lymphadenopathy. Paraganglioma was suspected and 24-hour urine demonstrated elevated normetanephrines (575 mcg/24 hours; normal, 5 to 290 mcg/24 hours) and vanillylmandelic acid (8.3 mg/24 hours; normal, 0.5 to 6.6 mg/24 hours). 68-Gallium DOTATATE positron emission tomography/CT showed weak uptake in the retroperitoneal mass and no other mass lesions.Results: Following preparation with alpha-adrenergic blockers, surgical excision was performed with diagnostic and curative intent. Postoperatively, hypertension and paroxysmal symptoms resolved completely. The histopathology report described seminoma with an entrapped large ganglion within the tumor.Conclusion: We describe a retroperitoneal seminoma with an entrapped ganglion causing hypertension and paroxysmal symptoms, with laboratory and imaging features compatible with paraganglioma. Awareness of the rare possibility of mechanical pressure on a ganglion, within the differential diagnosis of retroperitoneal mass and sympathetic symptoms may aid in clinical decision making in atypical cases.

Effects of Riluzole on Nr2B subunits of NMDA receptors in rat migraine model

Migraine, a major public health problem, occurring due to the consequences of serial changes in the nerve ganglion leading to an imbalance in the excitation and inhibition. The is the major neurotransmitter in the central nervous system, causing to the sensory neurons leading to sensitization and . The present study was done to determine the effects of on the Nr2B of NMDA receptors after inducing a migraine. The rats were treated with after inducing migraine with nitroglycerin 10mg/kg. The nitroglycerin treated rats showed intense staining for NR2B , and there was a decrease in the expression after treatment. This study concludes that the NR2B are during migraine and can be used to control those by its property.

In vitro Efficacy of Deltamethrin against Hyalomma anatolicum anatolicum

Tick and tick-borne diseases such as theileriosis,babesiosis, and Anaplasmosis pose a constant threato cattle health. Rhipicephalus (Boophilus) microplus andHyalomma anatolicum are the most commonly foundcattle tick species and cause significant economic lossesto dairy and leather industries by adversely affecting themilk production and quality of hides. Tick control strategyinvolves mainly the use of synthetic acaricides which resultsin the development of acaricide resistance. Deltamethrinacts on the parasites by contact and has strong lipophilicaction thus penetrates the cuticle nerve ganglion and block the motor activity. The presentstudy was aimed at the determination of in vitro efficacyof Deltamethrin against H. anatolicum ticks collected fromhealthy cattle of college farm and nearby dairy farms.