Enumerating Stem Cell Frequency: Neural Colony Forming Cell Assay

2013 ◽  
pp. 117-132 ◽  
Author(s):  
Sharon A. Louis ◽  
Carmen K. H. Mak
Keyword(s):  
Stem Cell ◽  
Cell Frequency ◽  
Cell Assay ◽  
Colony Forming Cell

Amino Acid Requirements of a Rat Sarcoma as Determined by a Stem Cell Assay

1987 ◽  
Vol 11 (3) ◽  
pp. 223-228 ◽  
Author(s):  
Timothy J. Miller ◽  
Robert S. Franco ◽  
William T. Chance ◽  
Orlando J. Martelo ◽  
Martin B. Popp
Keyword(s):  
Stem Cell ◽  
Amino Acid ◽  
Cell Assay ◽  
Amino Acid Requirements

scholarly journals Genetic control of the frequency of hematopoietic stem cells in mice: mapping of a candidate locus to chromosome 1.

1996 ◽  
Vol 183 (3) ◽  
pp. 1141-1150 ◽  
Author(s):  
C E Müller-Sieburg ◽  
R Riblet
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Inbred Strains ◽  
Cell Number ◽  
Chromosome 1 ◽  
Cell Frequency ◽  
Candidate Locus ◽  
Hematopoietic Stem ◽  
Differentiation And Proliferation

The genetic elements that govern the differentiation and proliferation of hematopoietic stem cells remain to be defined. We describe here marked strain-specific differences in the frequency of long-term culture-initiating cells (LTC-IC) in the bone marrow of different strains of mice. Mice of C57Bl/6 background showed the lowest levels of stem cells in marrow, averaging 2.4 +/- .06 LTC-IC/10(5) cells, BALB/c is intermediate (9.1 +/- 4.2/10(5) cells), and DBA/2 mice contained a 11-fold higher frequency of LTC-IC (28.1 +/- 16.5/10(5) cells) than C57Bl/6 mice. The genetic factors affecting the size of the stem cell pool were analyzed in the C57Bl/6 X DBA/2 recombinant inbred strains; LTC-IC frequencies ranged widely, indicating that stem cell frequencies are controlled by multiple genes. Quantitative trait linkage analysis suggested that two loci that have major quantitative effects are located on chromosome 1 near Adprp and Acrg, respectively. The mapping of the locus near Adprp was confirmed by finding an elevated stem cell frequency in B6.C-H25, a C57Bl/6 congenic strain that carries a portion of chromosome 1 derived from BALB/c mice. We have named this gene Scfr1 (stem cell frequency regulator 1). The allelic forms of this gene may be an important predictor of stem cell number and thus would be useful for evaluating cell sources in clinical stem cell transplantation.

scholarly journals Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia

Haematologica ◽  
2017 ◽  
Vol 102 (9) ◽  
pp. 1567-1577 ◽  
Author(s):  
Wenwen Wang ◽  
Thomas Stiehl ◽  
Simon Raffel ◽  
Van T. Hoang ◽  
Isabel Hoffmann ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Myeloid Leukemia ◽  
Cell Frequency ◽  
Hematopoietic Stem ◽  
Acute Myeloid

Human colorectal carcinoma: Patterns of sensitivity to chemotherapeutic agents in the human tumor stem cell assay

1982 ◽  
Vol 20 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Michael V. Agrez ◽  
John S. Kovach ◽  
Robert W. Beart ◽  
Joseph Rubin ◽  
Charles G. Moertel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Colorectal Carcinoma ◽  
Human Tumor ◽  
Chemotherapeutic Agents ◽  
Tumor Stem Cell ◽  
Cell Assay ◽  
Tumor Stem Cell Assay ◽  
Human Colorectal Carcinoma

The Usefulness of the Human Tumour Stem Cell Assay

1985 ◽  
pp. 98-108
Author(s):  
C. J. Williams
Keyword(s):  
Stem Cell ◽  
Human Tumour ◽  
Cell Assay

Growth Factor Enhancement of the In Vitro Stem Cell Assay

1984 ◽  
pp. 253-266
Author(s):  
G. Spitzer ◽  
F. Baker ◽  
G. Umbach ◽  
V. Hug ◽  
B. Tomasovic ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Assay
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