Design of Transmembrane Peptides: Coping with Sticky Situations

2013 ◽  
pp. 197-210 ◽  
Author(s):  
Arianna Rath ◽  
Charles M. Deber
Keyword(s):  
Transmembrane Peptides

scholarly journals Studies of transmembrane peptides by pulse dipolar spectroscopy with semi-rigid TOPP spin labels

2021 ◽  
Author(s):  
Igor Tkach ◽  
Ulf Diederichsen ◽  
Marina Bennati
Keyword(s):  
Molecular Level ◽  
Dipolar Interaction ◽  
Spin Labels ◽  
Paramagnetic Centers ◽  
Structural Adaptation ◽  
Paramagnetic Resonance ◽  
Transmembrane Peptides ◽  
Distance Distributions ◽  
Lipid Environment ◽  
Electron Paramagnetic

AbstractElectron paramagnetic resonance (EPR)-based pulsed dipolar spectroscopy measures the dipolar interaction between paramagnetic centers that are separated by distances in the range of about 1.5–10 nm. Its application to transmembrane (TM) peptides in combination with modern spin labelling techniques provides a valuable tool to study peptide-to-lipid interactions at a molecular level, which permits access to key parameters characterizing the structural adaptation of model peptides incorporated in natural membranes. In this mini-review, we summarize our approach for distance and orientation measurements in lipid environment using novel semi-rigid TOPP [4-(3,3,5,5-tetramethyl-2,6-dioxo-4-oxylpiperazin-1-yl)-L-phenylglycine] labels specifically designed for incorporation in TM peptides. TOPP labels can report single peak distance distributions with sub-angstrom resolution, thus offering new capabilities for a variety of TM peptide investigations, such as monitoring of various helix conformations or measuring of tilt angles in membranes. Graphical Abstract

scholarly journals Interfacial Anchor Properties of Tryptophan Residues in Transmembrane Peptides Can Dominate over Hydrophobic Matching Effects in Peptide−Lipid Interactions†

Biochemistry ◽  
2003 ◽  
Vol 42 (18) ◽  
pp. 5341-5348 ◽  
Author(s):  
Maurits R. R. de Planque ◽  
Boyan B. Bonev ◽  
Jeroen A. A. Demmers ◽  
Denise V. Greathouse ◽  
Roger E. Koeppe ◽  
...  
Keyword(s):  
Transmembrane Peptides ◽  
Lipid Interactions ◽  
Tryptophan Residues ◽  
Hydrophobic Matching

scholarly journals Phospholipid flip-flop modulated by transmembrane peptides WALP and melittin

2009 ◽  
Vol 168 (1) ◽  
pp. 37-52 ◽  
Author(s):  
Timothy C. Anglin ◽  
Krystal L. Brown ◽  
John C. Conboy
Keyword(s):  
Flip Flop ◽  
Transmembrane Peptides

scholarly journals Influence of Hydrophobic Mismatch and Amino Acid Composition on the Lateral Diffusion of Transmembrane Peptides

2010 ◽  
Vol 99 (5) ◽  
pp. 1447-1454 ◽  
Author(s):  
Sivaramakrishnan Ramadurai ◽  
Andrea Holt ◽  
Lars V. Schäfer ◽  
Victor V. Krasnikov ◽  
Dirk T.S. Rijkers ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Lateral Diffusion ◽  
Hydrophobic Mismatch ◽  
Transmembrane Peptides

Chemical synthesis of transmembrane peptides

Peptides 1992 ◽  
1993 ◽  
pp. 381-382 ◽  
Author(s):  
R. Bollhagen ◽  
J. Knolle ◽  
H. Betz ◽  
E. Grell
Keyword(s):  
Chemical Synthesis ◽  
Transmembrane Peptides

scholarly journals Observation of Backbone Cα-Deuteron Signals in Solid-State NMR Spectra of Labeled Alanines in Oriented Transmembrane Peptides

2010 ◽  
Vol 98 (3) ◽  
pp. 91a
Author(s):  
Nicholas J. Gleason ◽  
Vitaly V. Vostrikov ◽  
Roger E. Koeppe
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Nmr Spectra ◽  
Transmembrane Peptides

scholarly journals Cover Feature: 4‐Aminophthalimide Amino Acids as Small and Environment‐Sensitive Fluorescent Probes for Transmembrane Peptides (ChemBioChem 5/2020)

ChemBioChem ◽  
2020 ◽  
Vol 21 (5) ◽  
pp. 573-573
Author(s):  
Samantha Wörner ◽  
Franziska Rönicke ◽  
Anne S. Ulrich ◽  
Hans‐Achim Wagenknecht
Keyword(s):  
Amino Acids ◽  
Fluorescent Probes ◽  
Transmembrane Peptides

scholarly journals Transmembrane peptides used to investigate the homo-oligomeric interface and binding hot-spot of latent membrane protein 1

Biopolymers ◽  
2011 ◽  
pp. n/a-n/a ◽  
Author(s):  
Deanne W. Sammond ◽  
Catherine Joce ◽  
Ryan Takeshita ◽  
Sarah McQuate ◽  
Nilanjan Ghosh ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Hot Spot ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Transmembrane Peptides
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