Chromosomal Copy Number Analysis in Melanoma Diagnostics

2013 ◽  
pp. 199-226 ◽  
Author(s):  
Jeffrey P. North ◽  
Swapna S. Vemula ◽  
Boris C. Bastian
Keyword(s):  
Copy Number ◽  
Copy Number Analysis ◽  
Chromosomal Copy Number ◽  
Chromosomal Copy

scholarly journals Chromosomal copy number heterogeneity predicts survival rates across cancers

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erik van Dijk ◽  
Tom van den Bosch ◽  
Kristiaan J. Lenos ◽  
Khalid El Makrini ◽  
Lisanne E. Nijman ◽  
...  
Keyword(s):  
Copy Number ◽  
Cancer Survival ◽  
Survival Rates ◽  
Cancer Prognosis ◽  
Disease Outcomes ◽  
Distinct Disease ◽  
Cancer Types ◽  
Chromosomal Copy Number ◽  
Chromosomal Copy ◽  
Pan Cancer

AbstractSurvival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast, intra-tumour heterogeneity (ITH) has the potential to elucidate pan-cancer survival rates and the biology that drives cancer prognosis. Unfortunately, a comprehensive and effective framework to measure ITH across cancers is missing. Here, we introduce a scalable measure of chromosomal copy number heterogeneity (CNH) that predicts patient survival across cancers. We show that the level of ITH can be derived from a single-sample copy number profile. Using gene-expression data and live cell imaging we demonstrate that ongoing chromosomal instability underlies the observed heterogeneity. Analysing 11,534 primary cancer samples from 37 different malignancies, we find that copy number heterogeneity can be accurately deduced and predicts cancer survival across tissues of origin and stages of disease. Our results provide a unifying molecular explanation for the different survival rates observed between cancer types.

Screening and detection of chromosomal copy number alterations in the domestic horse using SNP‐array genotyping data

2021 ◽  
Author(s):  
Y. Pirosanto ◽  
N. Laseca ◽  
M. Valera ◽  
A. Molina ◽  
M. Moreno‐Millán ◽  
...  
Keyword(s):  
Copy Number ◽  
Snp Array ◽  
Domestic Horse ◽  
Copy Number Alterations ◽  
Chromosomal Copy Number ◽  
Chromosomal Copy

scholarly journals Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy

2009 ◽  
Vol 193 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Marian Grade ◽  
Jochen Gaedcke ◽  
Danny Wangsa ◽  
Sudhir Varma ◽  
Jaje Beckmann ◽  
...  
Keyword(s):  
Copy Number ◽  
Locally Advanced ◽  
Preoperative Chemoradiotherapy ◽  
Rectal Cancers ◽  
Chromosomal Copy Number ◽  
Chromosomal Copy ◽  
Copy Number Changes
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