Control Engineering and Systems Biology

2007 ◽  
pp. 267-288 ◽  
Author(s):  
Burton W. Andrews ◽  
Pablo A. Iglesias
Keyword(s):  
Systems Biology ◽  
Control Engineering

scholarly journals Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering

2016 ◽  
Vol 13 (117) ◽  
pp. 20151046 ◽  
Author(s):  
Fei He ◽  
Ettore Murabito ◽  
Hans V. Westerhoff
Keyword(s):  
Systems Biology ◽  
Synthetic Biology ◽  
Regulatory Networks ◽  
Computational Systems Biology ◽  
Control Engineering ◽  
Trade Offs ◽  
Metabolic Systems ◽  
Analytical Approaches

Metabolic pathways can be engineered to maximize the synthesis of various products of interest. With the advent of computational systems biology, this endeavour is usually carried out through in silico theoretical studies with the aim to guide and complement further in vitro and in vivo experimental efforts. Clearly, what counts is the result in vivo , not only in terms of maximal productivity but also robustness against environmental perturbations. Engineering an organism towards an increased production flux, however, often compromises that robustness. In this contribution, we review and investigate how various analytical approaches used in metabolic engineering and synthetic biology are related to concepts developed by systems and control engineering. While trade-offs between production optimality and cellular robustness have already been studied diagnostically and statically, the dynamics also matter. Integration of the dynamic design aspects of control engineering with the more diagnostic aspects of metabolic, hierarchical control and regulation analysis is leading to the new, conceptual and operational framework required for the design of robust and productive dynamic pathways.

Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

2019 ◽  
Vol 42 ◽  
Author(s):  
J. Alfredo Blakeley-Ruiz ◽  
Carlee S. McClintock ◽  
Ralph Lydic ◽  
Helen A. Baghdoyan ◽  
James J. Choo ◽  
...  
Keyword(s):  
Systems Biology ◽  
High Resolution ◽  
Experimental Design ◽  
Integrated Systems ◽  
Microbiome Research ◽  
Constructive Criticism

Abstract The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

Systems Biology

2009 ◽  
Author(s):  
Bernhard O. Palsson ◽  
Marc Abrams
Keyword(s):  
Systems Biology

Using integrative lipid systems biology to understand the role of Liver X receptors (LXRs) in male reproduction

2018 ◽  
Author(s):  
Sheba Jarvis ◽  
Lee Gethings ◽  
Raffaella Gadeleta ◽  
Emmanuelle Claude ◽  
Robert Winston ◽  
...  
Keyword(s):  
Systems Biology ◽  
Male Reproduction ◽  
Liver X Receptors ◽  
X Receptors

An Expert System Scenario for Computer-Aided Control Engineering

1984 ◽  
Author(s):  
James H. Taylor ◽  
Dean K. Frederick ◽  
John R. James
Keyword(s):  
Expert System ◽  
Control Engineering ◽  
Computer Aided

Bridging structural and systems biology through academic and industrial career experiences

2016 ◽  
Vol 4 (Suppl. 1) ◽  
pp. A2.4
Author(s):  
Montserrat Soler López
Keyword(s):  
Systems Biology ◽  
Career Experiences

INCO-WELD W.E. 686CPT

Alloy Digest ◽  
1996 ◽  
Vol 45 (8) ◽  
Keyword(s):  
Corrosion Resistance ◽  
Tensile Properties ◽  
Pollution Control ◽  
General Corrosion ◽  
Control Engineering ◽  
Alloy Content ◽  
Nickel Base ◽  
Welding Electrode

Abstract Inco-Weld Welding Electrode 686CPT is an all-position shielded-metal-arc (SMAW) electrode with highter (CR + Mo + W) content than most other nickel-base welding products. This higher alloy content increases the resistance to pitting, crevice, and general corrosion. Applications include the severest service in pollution control engineering. This datasheet provides information on composition, hardness, and tensile properties. It also includes information on corrosion resistance as well as joining. Filing Code: Ni-515. Producer or source: Inco Alloys International Inc.

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