Pretransplant Screening for Infection Exposure: Approach to the Patients with Epidemiologic and Geographic Risk Factors

Author(s):  
Deepa Nanayakkara ◽  
Joanna Schaenman
Keyword(s):  
Author(s):  
Young J. Juhn ◽  
Philip Wheeler ◽  
Chung-Il Wi ◽  
Joshua Bublitz ◽  
Euijung Ryu ◽  
...  

1995 ◽  
Vol 52 (5) ◽  
pp. 398-402 ◽  
Author(s):  
Jean-Francois Viel ◽  
Frantz Agis ◽  
Thierry Fest ◽  
Alain Dussaucy ◽  
Dominique Pobel

2020 ◽  
Vol 187 (8) ◽  
pp. 317-317 ◽  
Author(s):  
Jenni McDonald ◽  
Jane Clements

BackgroundMany cats in the UK are not neutered before reaching potential breeding age. The purpose of this investigation was to understand the prevalence of veterinarians’ behaviours around neutering cats at four months of age and to identify any needs of the veterinary profession on this.MethodsA sample of 483 veterinarians that completed a cross-sectional online questionnaire were included in quantitative and qualitative analyses.ResultsAlmost 70 per cent of veterinarians indicated they were comfortable carrying out neutering on cats of four months of age, and approximately half of veterinarians indicated they would recommend neutering client-owned cats at four months of age if practice policy permitted. There was no association found between these practices and geographic risk factors. Instead, neutering at four months was associated with the gender of the veterinarian, their practice policy and whether they routinely neuter unowned cats. Veterinarians have contrasting beliefs on similar themes, depending on whether they neuter kittens at four months or not, including differing opinions on general anaesthetic, surgery risks, owner compliance and their perceptions of neutering practices within the wider profession.ConclusionFamiliarity and experience with the procedure, alongside perceived norms, are central to beliefs. We also highlight informational and learning barriers.


2009 ◽  
Vol 8 (1) ◽  
Author(s):  
Ward P Myers ◽  
Andrea P Myers ◽  
Janet Cox-Singh ◽  
Hui C Lau ◽  
Benny Mokuai ◽  
...  

1986 ◽  
Vol 123 (3) ◽  
pp. 464-472 ◽  
Author(s):  
LYTT I. GARDNER ◽  
ROBERT R. REDFIELD ◽  
WAYNE M. LEDNAR ◽  
STANLEY M. LEMON ◽  
RICHARD N. MILLER

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.


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