In the paper, the concept of time-varying wires structure is proposed to avoid interference between wires and a mobile platform in a wire-driven parallel suspension system. A mathematical model, a kinematic notation model and a calculation model for interference between wires and the mobile platform have been built for it. When the mobile platform moves at a single degree of freedom pitch rotation, the motion equations of relevant hinge are deduced. The simulation results demonstrate that interference can be avoided in the wire-driven parallel manipulators with time-varying wires structure, and the workspace of the mobile platform may be enlarged. But different motions chosen for the hinge correspond to distinguishable sizes of workspace of the wire-driven parallel manipulators with time-varying wires structure. Therefore, according to the requirements to avoid interference, the motion of the hinge can be designed.