Tapping the Potential of Metabolomics in New Natural Products Discovery from Bacillus Species

2019 ◽  
pp. 201-215
Author(s):  
Zerihun T. Dame ◽  
Md Tofazzal Islam
Keyword(s):  
Natural Products ◽  
Bacillus Species ◽  
Natural Products Discovery

scholarly journals CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean

2020 ◽  
Vol 49 (D1) ◽  
pp. D509-D515
Author(s):  
Chuanyu Lyu ◽  
Tong Chen ◽  
Bo Qiang ◽  
Ningfeng Liu ◽  
Heyu Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Natural Products ◽  
Terrestrial Plants ◽  
Activity Data ◽  
Related Data ◽  
Free Data ◽  
Pharmacokinetic Properties ◽  
Natural Products Discovery ◽  
User Friendly

Abstract Marine organisms are expected to be an important source of inspiration for drug discovery after terrestrial plants and microorganisms. Despite the remarkable progress in the field of marine natural products (MNPs) chemistry, there are only a few open access databases dedicated to MNPs research. To meet the growing demand for mining and sharing for MNPs-related data resources, we developed CMNPD, a comprehensive marine natural products database based on manually curated data. CMNPD currently contains more than 31 000 chemical entities with various physicochemical and pharmacokinetic properties, standardized biological activity data, systematic taxonomy and geographical distribution of source organisms, and detailed literature citations. It is an integrated platform for structure dereplication (assessment of novelty) of (marine) natural products, discovery of lead compounds, data mining of structure-activity relationships and investigation of chemical ecology. Access is available through a user-friendly web interface at https://www.cmnpd.org. We are committed to providing a free data sharing platform for not only professional MNPs researchers but also the broader scientific community to facilitate drug discovery from the ocean.

Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery

2018 ◽  
Vol 20 (3) ◽  
pp. 1253-1270 ◽  
Author(s):  
Jose G. Maciá-Vicente ◽  
Yan-Ni Shi ◽  
Zakaria Cheikh-Ali ◽  
Peter Grün ◽  
Kyriaki Glynou ◽  
...  
Keyword(s):  
Natural Products ◽  
Endophytic Fungi ◽  
Root Endophytic Fungi ◽  
Natural Products Discovery

Spinosad - a case study: an example from a natural products discovery programme

2000 ◽  
Vol 56 (8) ◽  
pp. 696-702 ◽  
Author(s):  
Gary D Thompson ◽  
Robert Dutton ◽  
Thomas C Sparks
Keyword(s):  
Natural Products ◽  
Natural Products Discovery
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