Robotic Partial Hepatectomy for Colorectal Cancer Liver Metastases

2019 ◽  
pp. 385-395
Author(s):  
Eric C. H. Lai ◽  
Chung Ngai Tang
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Partial Hepatectomy ◽  
Colorectal Cancer Liver Metastases

scholarly journals Partial hepatectomy enhances growing of rat colorectal cancer cells CC531

2020 ◽  
Author(s):  
Borja Herrero de la Parte ◽  
Mikel González-Arribas ◽  
Iñaki Diaz-Sanz ◽  
Teodoro Palomares ◽  
Ignacio García-Alonso
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Cancer Cells ◽  
Partial Hepatectomy ◽  
Lateral Lobe ◽  
Male Rats ◽  
Hepatic Tissue ◽  
Liver Tumours ◽  
Colorectal Cancer Liver Metastases ◽  
Colorectal Cancer Cells

Abstract Background Nowadays, partial hepatectomy (PHx) is the gold standard for the treatment of colorectal cancer liver metastases. After removing a substantial amount of hepatic tissue, however, growth factors are released to induce liver regeneration. These cytokines may promote the proliferation of liver micrometastases or circulating tumour cells still present in the patient. The aim of this study was to assess the effect of PHx on the growth of liver metastases after intrasplenic cell inoculation. Methods Liver tumours were induced in 18 WAG/RijHsd male rats, by seeding 250,000 syngeneic colorectal cancer cells (CC-531) into the spleen. Twenty-eight days after tumour induction, the animals were sacrificed and the liver was removed and sliced to assess the relative tumour surface area (RTSA%). Results The RTSA% was significantly higher in animals which had undergone PHx than the controls (not hepatectomised) (46.98 ± 8.76% vs. 18.73 ± 5.65%; p < 0.05). While no differences were observed in the right lateral lobe, in either hepatectomised or non-hepatectomised animals, there were significant differences in liver surface occupied by metastases in the paramedian and caudate lobes in both groups. Conclusion In this experimental model, the process of growth of colorectal cancer cells in the liver clearly accelerates following PHx.

Abstract 3707: Captopril inhibits colorectal cancer liver metastases following 70% partial hepatectomy in a mouse model

2012 ◽  
Author(s):  
Shir Lin Koh ◽  
E. I. Ager ◽  
C. Malcontenti-Wilson ◽  
P L. Costa ◽  
V. Muralidharan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Liver Metastases ◽  
Partial Hepatectomy ◽  
Colorectal Cancer Liver Metastases

scholarly journals Is post‐transplant chemotherapy feasible in liver transplantation for colorectal cancer liver metastases?

2020 ◽  
Vol 40 (9) ◽  
pp. 461-464
Author(s):  
Giovanni Brandi ◽  
Angela Dalia Ricci ◽  
Alessandro Rizzo ◽  
Chiara Zanfi ◽  
Simona Tavolari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Transplantation ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Post Transplant
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