Everybody wants to analyse their data, but only few posses the data science expertise to do this. Motivated by this observation, we introduce a novel framework and system VisualSynth for human-machine collaboration in data science. Its aim is to democratize data science by allowing users to interact with standard spreadsheet software in order to perform and automate various data analysis tasks ranging from data wrangling, data selection, clustering, constraint learning, predictive modeling and auto-completion. VisualSynth relies on the user providing colored sketches, i.e., coloring parts of the spreadsheet, to partially specify data science tasks, which are then determined and executed using artificial intelligence techniques.