This article suggests ways in which a spatial perspective is relevant to questions of African economic history prior to formal colonization. Aspects of spatial analysis can help to identify and compare economically dynamic centres and subregions and to understand the qualities of regional and inter-regional systems. Spatial analysis can also illuminate various economic relationships between Africa and Europe; thus it is relevant to such issues as African adaptation to ‘legitimate’ trade and economic dependency. Among the main concepts discussed are central place theory, ‘growth centres’, port gateways, and dendritic marketing systems. The article focuses upon the Sierra Leone–Guinea plain and the larger Sierra Leone–Guinea inter-regional commercial system during the second half of the nineteenth century. Brief comparisons are made with other areas.