Stimuli-Responsive Polymeric Systems for Smart Drug Delivery

2020 ◽  
pp. 115-134
Author(s):  
Dariana Aristizabal Bedoya ◽  
Francisco N. Figueroa ◽  
Micaela A. Macchione ◽  
Miriam C. Strumia
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Polymeric Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

Dual Stimuli-Responsive Block Copolymers with Adjacent Redox- and Photo-Cleavable Linkages for Smart Drug Delivery

2020 ◽  
Vol 21 (8) ◽  
pp. 3342-3352
Author(s):  
Yu-Lun Lo ◽  
Ming-Fong Tsai ◽  
Yugendhar Soorni ◽  
Chin Hsu ◽  
Zi-Xian Liao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Stimuli Responsive ◽  
Smart Drug ◽  
Smart Drug Delivery

Leveraging Physiology for Precision Drug Delivery

2017 ◽  
Vol 97 (1) ◽  
pp. 189-225 ◽  
Author(s):  
Wujin Sun ◽  
Quanyin Hu ◽  
Wenyan Ji ◽  
Grace Wright ◽  
Zhen Gu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Material Chemistry ◽  
Therapeutic Benefits ◽  
Challenges And Opportunities ◽  
Smart Drug ◽  
Smart Drug Delivery

Physiological characteristics of diseases bring about both challenges and opportunities for targeted drug delivery. Various drug delivery platforms have been devised ranging from macro- to micro- and further into the nanoscopic scale in the past decades. Recently, the favorable physicochemical properties of nanomaterials, including long circulation, robust tissue and cell penetration attract broad interest, leading to extensive studies for therapeutic benefits. Accumulated knowledge about the physiological barriers that affect the in vivo fate of nanomedicine has led to more rational guidelines for tailoring the nanocarriers, such as size, shape, charge, and surface ligands. Meanwhile, progresses in material chemistry and molecular pharmaceutics generate a panel of physiological stimuli-responsive modules that are equipped into the formulations to prepare “smart” drug delivery systems. The capability of harnessing physiological traits of diseased tissues to control the accumulation of or drug release from nanomedicine has further improved the controlled drug release profiles with a precise manner. Successful clinical translation of a few nano-formulations has excited the collaborative efforts from the research community, pharmaceutical industry, and the public towards a promising future of smart drug delivery.

Dual stimuli-responsive polymeric hollow nanocapsules as “smart” drug delivery system against cancer

2020 ◽  
Vol 59 (13) ◽  
pp. 1492-1504 ◽  
Author(s):  
Rana Jahanban-Esfahlan ◽  
Bakhshali Massoumi ◽  
Mojtaba Abbasian ◽  
Amir Farnudiyan‐Habibi ◽  
Hadi Samadian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Smart Drug ◽  
Smart Drug Delivery

Intrinsic stimuli‐responsive nanocarriers for smart drug delivery of antibacterial agents—An in‐depth review of the last two decades

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Nikita Devnarain ◽  
Nawras Osman ◽  
Victoria Oluwaseun Fasiku ◽  
Sifiso Makhathini ◽  
Mohammed Salih ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Agents ◽  
Stimuli Responsive ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals HYDROGEL: RESPONSIVE STRUCTURES FOR DRUG DELIVERY

2021 ◽  
pp. 65-76
Author(s):  
MALLIKARJUN P. N. ◽  
ANUSHA S. ◽  
SAI NANDINI V. ◽  
RAMA RAO B. ◽  
KAMALA KUMARI P. V. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Molecules ◽  
Therapeutic Agents ◽  
Ionic Concentration ◽  
Stimuli Responsive ◽  
Electrical Fields ◽  
Smart Hydrogel ◽  
External Stimuli ◽  
Smart Drug ◽  
Smart Drug Delivery

Hydrogels are water-swollen 3D networks made of polymers, proteins, small molecules, or colloids. They are porous in structure and entrap/encapsulate large amounts of therapeutic agents and biopharmaceuticals. Their unique properties like biocompatibility, biodegradability, sensitivity to various stimuli, and the ability to be easily conjugated with hydrophilic and hydrophobic drugs with a controlled-release profile make hydrogels a smart drug delivery system. Smart hydrogel systems with various chemically and structurally responsive moieties exhibit responsiveness to external stimuli including temperature, pH, ionic concentration, light, magnetic fields, electrical fields, and chemical and biological stimuli with selected triggers includes polymers with multiple responsive properties have also been developed elegantly combining two or more stimuli-responsive mechanisms. This article emphasized the types, features, and various stimuli systems that produce responsive delivery of drugs.

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