scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

scholarly journals The Effective Combination between 3D Cancer Models and Stimuli-Responsive Nanoscale Drug Delivery Systems

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3295
Author(s):  
Federica Foglietta ◽  
Loredana Serpe ◽  
Roberto Canaparo
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Cell Cultures ◽  
Drug Delivery Systems ◽  
In Vitro Models ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Cancer Models

Stimuli-responsive drug-delivery systems (DDSs) have emerged as a potential tool for applications in healthcare, mainly in the treatment of cancer where versatile nanocarriers are co-triggered by endogenous and exogenous stimuli. Two-dimensional (2D) cell cultures are the most important in vitro model used to evaluate the anticancer activity of these stimuli-responsive DDSs due to their easy manipulation and versatility. However, some limitations suggest that these in vitro models poorly predict the outcome of in vivo studies. One of the main drawbacks of 2D cell cultures is their inadequate representation of the 3D environment’s physiological complexity, which sees cells interact with each other and the extracellular matrix (ECM) according to their specific cellular organization. In this regard, 3D cancer models are a promising approach that can overcome the main shortcomings of 2D cancer cell cultures, as these in vitro models possess many peculiarities by which they mimic in vivo tumors, including physiologically relevant cell–cell and cell–ECM interactions. This is, in our opinion, even more relevant when a stimuli-responsive DDS is being investigated. In this review, we therefore report and discuss endogenous and exogenous stimuli-responsive DDSs whose effectiveness has been tested using 3D cancer cell cultures.

Stimuli-responsive Polymeric nanosystems for therapeutic applications

2021 ◽  
Vol 27 ◽  
Author(s):  
Mayank Handa ◽  
Ajit Singh ◽  
S.J.S. Flora ◽  
Rahul Shukla
Keyword(s):  
Drug Delivery ◽  
Metallic Nanoparticles ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Delivery Systems ◽  
Specific Drug ◽  
Stimuli Responsive

Background: Recent past decades have reported emerging of polymeric nanoparticles as a promising technique for controlled and targeted drug delivery. As nanocarriers, they have high drug loading and delivery to the specific site or targeted cells with an advantage of no drug leakage within en route and unloading of a drug in a sustained fashion at the site. These stimuli-responsive systems are functionalized in dendrimers, metallic nanoparticles, polymeric nanoparticles, liposomal nanoparticles, quantum dots. Purpose of Review: The authors reviewed the potential of smart stimuli-responsive carriers for therapeutic application and their behavior in external or internal stimuli like pH, temperature, redox, light, and magnet. These stimuli-responsive drug delivery systems behave differently in In vitro and In vivo drug release patterns. Stimuli-responsive nanosystems include both hydrophilic and hydrophobic systems. This review highlights the recent development of the physical properties and their application in specific drug delivery. Conclusion: The stimuli (smart, intelligent, programmed) drug delivery systems provide site-specific drug delivery with potential therapy for cancer, neurodegenerative, lifestyle disorders. As development and innovation, the stimuli-responsive based nanocarriers are moving at a fast pace and huge demand for biocompatible and biodegradable responsive polymers for effective and safe delivery.

Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Containing Rice Bran Oil for Enhanced Fenofibrate Oral Delivery: In Vitro Digestion, Ex Vivo Permeability, and In Vivo Bioavailability Studies

2020 ◽  
Vol 21 (6) ◽  
Author(s):  
Christina Karavasili ◽  
Ioannis I. Andreadis ◽  
Maria P. Tsantarliotou ◽  
Ioannis A. Taitzoglou ◽  
Paschalina Chatzopoulou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Rice Bran ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Rice Bran Oil ◽  
Ex Vivo ◽  
In Vitro Digestion ◽  
Delivery Systems

scholarly journals Ex Vivo and In Vivo Characterization of Interpolymeric Blend/Nanoenabled Gastroretentive Levodopa Delivery Systems

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Ndidi C. Ngwuluka ◽  
Yahya E. Choonara ◽  
Girish Modi ◽  
Lisa C. du Toit ◽  
Pradeep Kumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Pharmacokinetic Parameters ◽  
Gastric Residence Time ◽  
Systemic Bioavailability ◽  
Absorption Window

One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances of two gastroretentive systems (PXLNETand IPB matrices) in comparison to Madopar® HBS capsules. The pig model was used to assess gastric residence time and pharmacokinetic parameters using blood, cerebrospinal fluid (CSF), and urine samples. Histopathology and cytotoxicity testing were also undertaken. The pharmacokinetic parameters indicated that levodopa was liberated from the drug delivery systems, absorbed, widely distributed, metabolized, and excreted.Cmaxwere 372.37, 257.02, and 461.28 ng/mL and MRT were 15.36, 14.98, and 13.30 for Madopar HBS capsules,PXLNET, and IPB, respectively. In addition, X-ray imaging indicated that the gastroretentive systems have the potential to reside in the stomach for 7 hours. There was strong in vitro-in vivo correlation for all formulations withr2values of 0.906, 0.935, and 0.945 for Madopar HBS capsules,PXLNET, and IPB, respectively. Consequently,PXLNETand IPB matrices have pertinent potential as gastroretentive systems for narrow absorption window drugs (e.g., L-dopa) and, in this application specifically, enhanced the central nervous system and/or systemic bioavailability of such drugs.

In Vitro Investigations of Smart Drug Delivery Systems Based on Redox-Sensitive Cross-Linked Micelles

2013 ◽  
Vol 13 (12) ◽  
pp. 1661-1670 ◽  
Author(s):  
Sébastien Cajot ◽  
Daureen Schol ◽  
Fabienne Danhier ◽  
Véronique Préat ◽  
Marie-Claire Gillet De Pauw ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

In Vitro , Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems

2020 ◽  
pp. 57-98
Author(s):  
Ljiljana Djekic ◽  
Martina Martinovic
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems

Janus Nano- and Microparticles as Smart Drug Delivery Systems

2016 ◽  
Vol 17 (8) ◽  
pp. 673-682 ◽  
Author(s):  
Ibrahim M. El-Sherbiny ◽  
Yasmine Abbas
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Mono and Multi‐Stimuli Responsive Polymers: Application as Intelligent Nano‐Drug Delivery Systems

2021 ◽  
pp. 237-265
Author(s):  
Archana Sidagouda Patil ◽  
Anand Panchakshari Gadad ◽  
Panchaxari Mallappa Dandagi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Nano Drug Delivery
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