Computer Aided System for Nuclei Localization in Histopathological Images Using CNN

2020 ◽  
pp. 226-234
Author(s):  
Mahendra G. Kanojia ◽  
Mohd. Abuzar Mohd. Haroon Ansari ◽  
Niketa Gandhi ◽  
S. K. Yadav
Keyword(s):  
Computer Aided ◽  
Histopathological Images

scholarly journals Breast histopathological image analysis using image processing techniques for diagnostic puposes: A methodological review

2021 ◽  
Vol 46 (1) ◽  
Author(s):  
R Rashmi ◽  
Keerthana Prasad ◽  
Chethana Babu K Udupa
Keyword(s):  
Breast Cancer ◽  
Image Processing ◽  
Medical Image ◽  
Human Life ◽  
Medical Image Processing ◽  
Histopathological Analysis ◽  
Image Processing Techniques ◽  
Computer Aided ◽  
Histopathological Images ◽  
Processing Techniques

AbstractBreast cancer in women is the second most common cancer worldwide. Early detection of breast cancer can reduce the risk of human life. Non-invasive techniques such as mammograms and ultrasound imaging are popularly used to detect the tumour. However, histopathological analysis is necessary to determine the malignancy of the tumour as it analyses the image at the cellular level. Manual analysis of these slides is time consuming, tedious, subjective and are susceptible to human errors. Also, at times the interpretation of these images are inconsistent between laboratories. Hence, a Computer-Aided Diagnostic system that can act as a decision support system is need of the hour. Moreover, recent developments in computational power and memory capacity led to the application of computer tools and medical image processing techniques to process and analyze breast cancer histopathological images. This review paper summarizes various traditional and deep learning based methods developed to analyze breast cancer histopathological images. Initially, the characteristics of breast cancer histopathological images are discussed. A detailed discussion on the various potential regions of interest is presented which is crucial for the development of Computer-Aided Diagnostic systems. We summarize the recent trends and choices made during the selection of medical image processing techniques. Finally, a detailed discussion on the various challenges involved in the analysis of BCHI is presented along with the future scope.

scholarly journals A Hybrid-Attention Nested UNet for Nuclear Segmentation in Histopathological Images

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongliang He ◽  
Chi Zhang ◽  
Jie Chen ◽  
Ruizhe Geng ◽  
Luyang Chen ◽  
...  
Keyword(s):  
Image Analysis ◽  
State Of The Art ◽  
The State ◽  
Dense Network ◽  
Crucial Step ◽  
Full Resolution ◽  
Proposed Model ◽  
Computer Aided ◽  
Histopathological Images ◽  
Nuclear Segmentation

Nuclear segmentation of histopathological images is a crucial step in computer-aided image analysis. There are complex, diverse, dense, and even overlapping nuclei in these histopathological images, leading to a challenging task of nuclear segmentation. To overcome this challenge, this paper proposes a hybrid-attention nested UNet (Han-Net), which consists of two modules: a hybrid nested U-shaped network (H-part) and a hybrid attention block (A-part). H-part combines a nested multi-depth U-shaped network and a dense network with full resolution to capture more effective features. A-part is used to explore attention information and build correlations between different pixels. With these two modules, Han-Net extracts discriminative features, which effectively segment the boundaries of not only complex and diverse nuclei but also small and dense nuclei. The comparison in a publicly available multi-organ dataset shows that the proposed model achieves the state-of-the-art performance compared to other models.

Computer-aided methods for 3-D visualization of serial sections and thick biological specimens

1992 ◽  
Vol 50 (2) ◽  
pp. 1060-1061
Author(s):  
Mark Ellisman ◽  
Maryann Martone ◽  
Gabriel Soto ◽  
Eleizer Masliah ◽  
David Hessler ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Three Dimensional ◽  
Neuritic Plaque ◽  
Dimensional Structure ◽  
Data Sets ◽  
Molecular Physiology ◽  
Research Activities ◽  
Computer Aided ◽  
Dimensional Reconstruction

Structurally-oriented biologists examine cells, tissues, organelles and macromolecules in order to gain insight into cellular and molecular physiology by relating structure to function. The understanding of these structures can be greatly enhanced by the use of techniques for the visualization and quantitative analysis of three-dimensional structure. Three projects from current research activities will be presented in order to illustrate both the present capabilities of computer aided techniques as well as their limitations and future possibilities.The first project concerns the three-dimensional reconstruction of the neuritic plaques found in the brains of patients with Alzheimer's disease. We have developed a software package “Synu” for investigation of 3D data sets which has been used in conjunction with laser confocal light microscopy to study the structure of the neuritic plaque. Tissue sections of autopsy samples from patients with Alzheimer's disease were double-labeled for tau, a cytoskeletal marker for abnormal neurites, and synaptophysin, a marker of presynaptic terminals.

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