PET Imaging in Multiple Sclerosis

2020 ◽  
pp. 893-916
Author(s):  
Chris W. J. van der Weijden ◽  
Jan F. Meilof ◽  
Erik F. J. de Vries
Keyword(s):  
Multiple Sclerosis ◽  
Pet Imaging

scholarly journals Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis

2010 ◽  
Vol 6 (3) ◽  
pp. 354-361 ◽  
Author(s):  
Unsong Oh ◽  
Masahiro Fujita ◽  
Vasiliki N. Ikonomidou ◽  
Iordanis E. Evangelou ◽  
Eiji Matsuura ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pet Imaging ◽  
Glial Activation ◽  
Translocator Protein

scholarly journals Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Wissam Beaino ◽  
Bieneke Janssen ◽  
Gijs Kooij ◽  
Susanne M. A. van der Pol ◽  
B. van Het Hof ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pet Imaging ◽  
Purinergic Receptors

scholarly journals A new frontier for amyloid PET imaging: multiple sclerosis

2018 ◽  
Vol 46 (2) ◽  
pp. 276-279 ◽  
Author(s):  
Silvia Morbelli ◽  
Matteo Bauckneht ◽  
Selene Capitanio ◽  
Matteo Pardini ◽  
Luca Roccatagliata ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pet Imaging ◽  
Amyloid Pet ◽  
New Frontier ◽  
Amyloid Pet Imaging

PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: A comparison between [11C]CIC and [11C]MeDAS

NeuroImage ◽  
2014 ◽  
Vol 87 ◽  
pp. 395-402 ◽  
Author(s):  
Daniele de Paula Faria ◽  
Erik F.J. de Vries ◽  
Jurgen W.A. Sijbesma ◽  
Rudi A.J.O. Dierckx ◽  
Carlos A. Buchpiguel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mouse Model ◽  
Pet Imaging

PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

2014 ◽  
Vol 41 (5) ◽  
pp. 995-1003 ◽  
Author(s):  
Daniele de Paula Faria ◽  
Sjef Copray ◽  
Jurgen W. A. Sijbesma ◽  
Antoon T. M. Willemsen ◽  
Carlos A. Buchpiguel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pet Imaging ◽  
Rat Model ◽  
Focal Demyelination

scholarly journals Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes

2016 ◽  
Vol 9 ◽  
Author(s):  
Pekka Poutiainen ◽  
Merja Jaronen ◽  
Francisco J. Quintana ◽  
Anna-Liisa Brownell
Keyword(s):  
Multiple Sclerosis ◽  
Precision Medicine ◽  
Pet Imaging ◽  
Reactive Astrocytes

scholarly journals Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: A [11C]TMSX Brain PET Study

2013 ◽  
Vol 33 (9) ◽  
pp. 1394-1401 ◽  
Author(s):  
Eero Rissanen ◽  
Jere R Virta ◽  
Teemu Paavilainen ◽  
Jouni Tuisku ◽  
Semi Helin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Pet Imaging ◽  
Progressive Multiple Sclerosis ◽  
Secondary Progressive Multiple Sclerosis ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Secondary Progressive ◽  
Normal Appearing White Matter ◽  
Adenosine A2a

In this study, positron emission tomography (PET) imaging with a radioligand to adenosine A2A receptors (A2AR)—a potent regulator of inflammation—was used to gain insight into the molecular alterations in normal-appearing white matter (NAWM) and gray matter (GM) in secondary progressive multiple sclerosis (SPMS). Normal-appearing white matter and GM, despite seeming normal in conventional mangnetic resonance imaging (MRI), are important loci of widespread inflammation, neuronal damage, and source of progressive disability in multiple sclerosis (MS). Dynamic PET imaging using A2AR-specific [ 11 C]TMSX and brain MRI with diffusion tensor imaging were performed to eight SPMS patients and seven healthy controls. Distribution volumes ( VT) of [ 11 C]TMSX were analyzed from 13 regions of interest using Logan plot with arterial plasma input. The SPMS patients had significantly increased [ 11 C]TMSX- VT in NAWM compared with controls (mean (s.d.): 0.55 (± 0.08) vs. 0.45 (± 0.05); P = 0.036). Both the increased VT and the decreased fractional anisotropy (FA) in NAWM were associated with higher expanded disability status scale (EDSS) scores ( P = 0.030 and P = 0.012, respectively), whereas the T2-lesion load of SPMS patients did not correlate with EDSS. This study shows, that A2ARs are increased in the brain of SPMS patients, and that [ 11 C]TMSX-PET provides a novel approach to learn about central nervous system pathology in SPMS in vivo.

scholarly journals Feasibility of Imaging Myelin Lesions in Multiple Sclerosis

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Maria I. Zavodszky ◽  
John F. Graf ◽  
Cristina A. Tan Hehir
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Pet Imaging ◽  
Basic Protein ◽  
Therapy Monitoring ◽  
Model Parameters ◽  
Image Simulation ◽  
Experimental Conditions ◽  
Feasibility Assessment ◽  
Complementary Method

The goal of this study was to provide a feasibility assessment for PET imaging of multiple sclerosis (MS) lesions based on their decreased myelin content relative to the surrounding normal-appearing brain tissue. The imaging agent evaluated for this purpose is a molecule that binds strongly and specifically to myelin basic protein. Physiology-based pharmacokinetic modeling combined with PET image simulation applied to a brain model was used to examine whether such an agent would allow the differentiation of artificial lesions 4–10 mm in diameter from the surrounding normal-looking white and gray matter. Furthermore, we examined how changes in agent properties, model parameters, and experimental conditions can influence imageability, identifying a set of conditions under which imaging of MS lesions might be feasible. Based on our results, we concluded that PET imaging has the potential to become a useful complementary method to MRI for MS diagnosis and therapy monitoring.

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