Cytochrome P450 Isozymes

2021 ◽  
pp. 515-515
Keyword(s):  
Cytochrome P450 ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes

Antibodies as Probes of Cytochrome P450 Isozymes

1986 ◽  
pp. 95-106 ◽  
Author(s):  
Paul E. Thomas ◽  
Linda M. Reik ◽  
Sarah L. Maines ◽  
Stelvio Bandiera ◽  
Dene E. Ryan ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes

Efavirenz-induced neurological symptoms in rare homozygote CYP2B6 *2/*2 (C64T)

2007 ◽  
Vol 18 (8) ◽  
pp. 575-576 ◽  
Author(s):  
Osamu Usami ◽  
Yugo Ashino ◽  
Yuichi Komaki ◽  
Masafumi Tomaki ◽  
Toshiya Irokawa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytochrome P450 ◽  
Plasma Concentrations ◽  
Highly Active ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Hiv 1 ◽  
Rare Homozygote ◽  
Hepatic Cytochrome

Some of the HIV-1-infected patients who were given highly active anti-retroviral therapy (HAART) including efavirenz (EFV) presented adverse central nervous system (CNS) symptoms such as fatigue and insomnia. The incidence of adverse CNS symptoms is associated with hepatic cytochrome P450 isozymes (CYP2B6) polymorphisms. For example, CYP2B6 *6 (G516T and A785G) and *7 (G516T, A785G and C1459T) prolonged the EFV half-life despite discontinuation of EFV. CYP2B6 *2/*2 (C64T) is extremely rare and there have been no data describing the EFV plasma concentrations in C64T homozygous patients, who developed adverse CNS symptoms. C64T homozygous possibly has some catalytic defects.

scholarly journals Effect of some inducers on the intralobular distribution of cytochrome P450 isozymes of the rat liver.

1991 ◽  
Vol 55 ◽  
pp. 312
Author(s):  
Hiromi Yamazaki ◽  
Keiko Nishiguchi ◽  
Palitha Serasinghe ◽  
Soma Serasinghe ◽  
Suehiro Nakanishi
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes
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