A Big-Data Variational Bayesian Framework for Supporting the Prediction of Functional Outcomes in Wake-Up Stroke Patients

Background: Statin therapy has been shown to be effective in the prevention of ischemic stroke. In addition, recent studies have suggested that prior statin therapy could lower the initial stroke severity and improve stroke functional outcomes in the event of stroke. It was speculated that prestroke statin use may enhance collateral circulation and result in favorable functional outcomes. Objective: The aim of the study was to investigate the association of prestroke statin use with leptomeningeal collaterals and to determine the association of prestroke statin use with stroke severity and functional outcome in acute ischemic stroke patients. Methods: We prospectively and consecutively enrolled 239 acute ischemic stroke patients with acute infarction due to occlusion of the middle cerebral artery within 24 h in the neurology department of West China Hospital from May 2011 to April 2017. Computed tomographic angiography (CTA) imaging was performed for all patients to detect middle cerebral artery thrombus; regional leptomeningeal collateral score (rLMCS) was used to assess the degree of collateral circulation; the National Institutes of Health Stroke Scale (NIHSS) was used to measure stroke severity at admission; the modified Rankin scale (mRS) was used to measure outcome at 90 days; and premorbid medications were recorded. Univariate and multivariate analyses were performed. Results: Overall, 239 patients met the inclusion criteria. Fifty-four patients used statins, and 185 did not use statins before stroke onset. Prestroke statin use was independently associated with good collateral circulation (rLMCS > 10) (odds ratio [OR], 4.786; 95% confidence interval [CI], 1.195–19.171; P = 0.027). Prestroke statin use was not independently associated with lower stroke severity (NIHSS score≤14) (OR, 1.955; 95% CI, 0.657–5.816; p = 0.228), but prestroke statin use was independently associated with favorable outcome (mRS score≤2) (OR, 3.868; 95% CI, 1.325–11.289; P = 0.013). Conclusions: Our findings suggest that prestroke statin use was associated with good leptomeningeal collaterals and clinical outcomes in acute ischemic stroke (AIS) patients presenting with occlusion of the middle cerebral artery. However, clinical studies should be conducted to verify this claim.

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The effect of robot-assisted gait training on cortical activation in stroke patients: A functional near-infrared spectroscopy study

Neurorehabilitation ◽

10.3233/nre-210034 ◽

2021 ◽

pp. 1-9

Author(s):

Kyeong Joo Song ◽

Min Ho Chun ◽

Junekyung Lee ◽

Changmin Lee

Keyword(s):

Gait Speed ◽

Functional Outcomes ◽

Near Infrared ◽

Gait Training ◽

Berg Balance Scale ◽

Cortical Activation ◽

Control Group ◽

Stroke Patients ◽

Robot Assisted ◽

Functional Near Infrared Spectroscopy

OBJECTIVE: To investigate the effects of the robot–assisted gait training on cortical activation and functional outcomes in stroke patients. METHODS: The patients were randomly assigned: training with Morning Walk® (Morning Walk group; n = 30); conventional physiotherapy (control group; n = 30). Rehabilitation was performed five times a week for 3 weeks. The primary outcome was the cortical activation in the Morning Walk group. The secondary outcomes included gait speed, 10-Meter Walk Test (10MWT), FAC, Motricity Index–Lower (MI–Lower), Modified Barthel Index (MBI), Rivermead Mobility Index (RMI), and Berg Balance Scale (BBS). RESULTS: Thirty-six subjects were analyzed, 18 in the Morning Walk group and 18 in the control group. The cortical activation was lower in affected hemisphere than unaffected hemisphere at the beginning of robot rehabilitation. After training, the affected hemisphere achieved a higher increase in cortical activation than the unaffected hemisphere. Consequently, the cortical activation in affected hemisphere was significantly higher than that in unaffected hemisphere (P = 0.036). FAC, MBI, BBS, and RMI scores significantly improved in both groups. The Morning Walk group had significantly greater improvements than the control group in 10MWT (P = 0.017), gait speed (P = 0.043), BBS (P = 0.010), and MI–Lower (P = 0.047) scores. CONCLUSION: Robot-assisted gait training not only improved functional outcomes but also increased cortical activation in stroke patients.

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Relationship between Comorbid Cognitive Impairment and Functional Outcomes in Stroke Patients with Spatial Neglect

Brain & Neurorehabilitation ◽

10.12786/bn.2016.9.1.37 ◽

2016 ◽

Vol 9 (1) ◽

pp. 37 ◽

Cited By ~ 1

Author(s):

Eun Hwa Jeong ◽

Bo-Ram Kim ◽

Jongmin Lee

Keyword(s):

Cognitive Impairment ◽

Functional Outcomes ◽

Spatial Neglect ◽

Stroke Patients

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Poster 99 The Effects of Pre-Morbid Anxiety and Depression on Functional Outcomes in Acute Stroke Patients Admitted to Inpatient Rehabilitation

PM&R ◽

10.1016/j.pmrj.2015.06.138 ◽

2015 ◽

Vol 7 ◽

pp. S123-S124

Author(s):

David B. Essaff ◽

Sarah Ackroyd ◽

Kevin Rhie ◽

Katarzyna B. Iwan ◽

Jennifer Fleeman ◽

...

Keyword(s):

Acute Stroke ◽

Functional Outcomes ◽

Inpatient Rehabilitation ◽

Anxiety And Depression ◽

Stroke Patients

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Symmetrical event-related EEG/fMRI information fusion in a variational Bayesian framework

NeuroImage ◽

10.1016/j.neuroimage.2007.01.044 ◽

2007 ◽

Vol 36 (1) ◽

pp. 69-87 ◽

Cited By ~ 101

Author(s):

Jean Daunizeau ◽

Christophe Grova ◽

Guillaume Marrelec ◽

Jérémie Mattout ◽

Saad Jbabdi ◽

...

Keyword(s):

Information Fusion ◽

Bayesian Framework ◽

Variational Bayesian

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Dose-Response Effect of Daily Rehabilitation Time on Functional Gain in Stroke Patients

Annals of Rehabilitation Medicine ◽

10.5535/arm.2020.44.2.101 ◽

2020 ◽

Vol 44 (2) ◽

pp. 101-108

Author(s):

Hanbit Ko ◽

Howook Kim ◽

Yeongwook Kim ◽

Min Kyun Sohn ◽

Sungju Jee

Keyword(s):

Functional Outcomes ◽

Treatment Time ◽

Rehabilitation Medicine ◽

Berg Balance Scale ◽

Functional Change ◽

Daily Treatment ◽

Stroke Patients ◽

Rehabilitation Treatment ◽

Dose Response Effect ◽

Functional Gain

Objective To demonstrate the effect of daily treatment time on recovery of functional outcomes and how each type of rehabilitation treatment influences the improvement of subgroups of functional outcomes in stroke patients.Methods We conducted a retrospective study in 168 patients who were admitted to the Department of Rehabilitation Medicine between 2015 and 2016. Patients who experienced their first-ever stroke and unilateral lesions were included. All patients underwent conventional rehabilitation treatment, and each treatment was administered one to two times a day depending on individual and treatment room schedules. Based on the mean daily treatment time, patients were divided into two groups: a high-amount group (n=54) and low-amount group (n=114). Outcomes were measured through the Korean version of Modified Barthel Index (MBI), FuglMeyer Assessment of the upper extremity, Trunk Impairment Scale (TIS), and Berg Balance Scale (BBS) scores on admission and at discharge.Results The functional change and scores at discharge of MBI, TIS, and BBS were greater in the high-amount group than in the low-amount group. Among various types of rehabilitation treatments, occupational therapy training showed significant correlation with MBI, TIS, and BBS gain from admission to discharge.Conclusion The amount of daily mean treatment in post-stroke patients plays an important role in recovery. Mean daily rehabilitation treatment time seems to correlate with improved balance and basic activities of daily living after stroke.

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