CADA Challenge: Rupture Risk Assessment Using Computational Fluid Dynamics

2021 ◽  
pp. 75-86
Author(s):  
Kartik Jain
Keyword(s):  
Fluid Dynamics ◽  
Risk Assessment ◽  
Computational Fluid Dynamics ◽  
Rupture Risk

Computational Fluid Dynamics of a Fatal Ruptured Anterior Communicating Artery Aneurysm

2017 ◽  
Vol 78 (06) ◽  
pp. 610-616 ◽  
Author(s):  
Helena Švihlová ◽  
Alena Sejkorová ◽  
Tomáš Radovnický ◽  
Daniel Adámek ◽  
Jaroslav Hron ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Artery Aneurysm ◽  
Aneurysm Rupture ◽  
Anterior Communicating Artery ◽  
Rupture Risk ◽  
Anterior Communicating Artery Aneurysm ◽  
Computational Fluid Dynamics Cfd ◽  
Inflow Jet ◽  
Rupture Site

AbstractComputational fluid dynamics (CFD) has been studied as a tool for the stratification of aneurysm rupture risk. We performed CFD analysis in a patient operated on for a ruptured anterior communicating artery aneurysm. The point of rupture was identified during surgery. The aneurysm and blood vessels were segmented from computed tomography angiography to prepare a model for simulations. We found that the streamlines showed a concentrated inflow jet directed straight at the rupture point, and high wall shear stress was found at the point of rupture in the aneurysm sac. Thus specific local hemodynamics may be indicative of the aneurysm rupture site.

scholarly journals Computational fluid dynamics as a risk assessment tool for aneurysm rupture

2019 ◽  
Vol 47 (1) ◽  
pp. E12 ◽  
Author(s):  
Yuichi Murayama ◽  
Soichiro Fujimura ◽  
Tomoaki Suzuki ◽  
Hiroyuki Takao
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Clinical Decision Making ◽  
Assessment Tool ◽  
Clinical Decision ◽  
Aneurysm Rupture ◽  
Hemodynamic Parameters ◽  
Rupture Risk ◽  
Clinical Role ◽  
Risk Of Rupture

OBJECTIVEThe authors reviewed the clinical role of computational fluid dynamics (CFD) in assessing the risk of intracranial aneurysm rupture.METHODSA literature review was performed to identify reports on CFD assessment of aneurysms using PubMed. The usefulness of various hemodynamic parameters, such as wall shear stress (WSS) and the Oscillatory Shear Index (OSI), and their role in aneurysm rupture risk analysis, were analyzed.RESULTSThe authors identified a total of 258 published articles evaluating rupture risk, growth, and endovascular device assessment. Of these 258 articles, 113 matching for CFD and hemodynamic parameters that contribute to the risk of rupture (such as WSS and OSI) were identified. However, due to a lack of standardized methodology, controversy remains on each parameter’s role.CONCLUSIONSAlthough controversy continues to exist on which risk factors contribute to predict aneurysm rupture, CFD can provide additional parameters to assess this rupture risk. This technology can contribute to clinical decision-making or evaluation of efficacy for endovascular methods and devices.

scholarly journals 590Development of a patient-specific computational fluid dynamics model of the LA in AF for stroke risk assessment

EP Europace ◽  
2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii120-iii121 ◽  
Author(s):  
A. Masci ◽  
D. Forti ◽  
M. Alessandrini ◽  
F. Menghini ◽  
L. Dede ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Risk Assessment ◽  
Computational Fluid Dynamics ◽  
Stroke Risk ◽  
Patient Specific ◽  
Dynamics Model ◽  
Computational Fluid Dynamics Model

scholarly journals The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study

2019 ◽  
Vol 9 ◽  
Author(s):  
Alessandro Masci ◽  
Lorenzo Barone ◽  
Luca Dedè ◽  
Marco Fedele ◽  
Corrado Tomasi ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Atrial Fibrillation ◽  
Risk Assessment ◽  
Computational Fluid Dynamics ◽  
Left Atrium ◽  
Stroke Risk ◽  
The Impact

scholarly journals Computational Fluid Dynamics in Unruptured Intracranial Aneurysms

2018 ◽  
Vol 32 (2) ◽  
pp. 332-339 ◽  
Author(s):  
Maruf Matmusaev ◽  
Yasuhiro Yamada ◽  
Tsukasa Kawase ◽  
Riki Tanaka ◽  
Miyatani Kyosuke ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Intracranial Aneurysms ◽  
Thin Wall ◽  
Rupture Risk ◽  
Ct Angiogram ◽  
Aneurysm Wall ◽  
Unruptured Intracranial Aneurysms ◽  
Increased Risk ◽  
Risk Of Rupture

Abstract Introduction and Objective: Intracranial aneurysm, also known as brain aneurysm, is a cerebrovascular disorder in which weakness in the wall of a cerebral artery causes a localized dilation or ballooning of the blood vessel. There is no objective way, device or tools, of predicting rupture of aneurysm so far. Computational fluid dynamics (CFDs) was proposed as a tool to identify the rupture risk. Purpose of study: To reveal the correlation of CFD findings with intraoperative microscopic findings and prove the relevance of CFDin the prediction of rupture risk and in the management of unruptured intracranial aneurysms. Subjects and Methods: A prospective cohort study was conducted inNeurosurgery department of Fujita Health University Banbuntane Hotokukai Hospital, Nagoya, Japanduring a 3‑month period in 2018,from January to March, Ten patientswere diagnosed unruptured intracranial aneurysms (UIA). In diagnosis computed tomography (CT) angiogram, CFD and digital subtraction angiogram were included. Intraoperatively microscopic examination of the aneurysm wall was carried out and images recorded. The correlation between microscopic dome morphology and CFD information was performed. Results: Nine cases were found intraoperatively to have a higher risk of rupture based on the thinning of the wall. One cases had an atherosclerotic wall. All cases had low wall shear stress (WSS). In 90 % of cases Low WSS was able to predict the potency rupture risk in the near future. Conclusions: This study of CFD and its correlation with intraoperativefindings of the aneurysm suggested that low WSS of the aneurysm wall is associated with thin wall aneurysm and hence increased risk of aneurysm rupture. Thus CFD can be used to predict the risk of rupture of unruptured aneurysm and for planning of its treatment.

scholarly journals Hemodynamics in aneurysm blebs with different wall characteristics

2020 ◽  
pp. neurintsurg-2020-016601
Author(s):  
Seyedeh Fatemeh Salimi Ashkezari ◽  
Fernando Mut ◽  
Bong Jae Chung ◽  
Alexander K Yu ◽  
Christopher J Stapleton ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Shear Stress ◽  
Intracranial Aneurysms ◽  
Wall Stress ◽  
Shear Strain Rate ◽  
Rupture Risk ◽  
Ruptured Aneurysms ◽  
The Relationship ◽  
Development And Evolution

BackgroundBlebs are important secondary structures of intracranial aneurysms associated with increased rupture risk and can affect local wall stress and hemodynamics. Mechanisms of bleb development and evolution are not clearly understood. We investigate the relationship between blebs with different wall characteristics and local hemodynamics and rupture sites.MethodsBlebs with different wall appearances in intra-operative videos were analyzed with image-based computational fluid dynamics. Thin red blebs were compared against thick atherosclerotic/hyperplastic white/yellow blebs. Rupture points were identified in videos of ruptured aneurysms harboring blebs.ResultsThin blebs tended to be closer to the inflow than atherosclerotic blebs of the same aneurysm (P=0.0234). Blebs near the inflow had higher velocity (P=0.0213), vorticity (P=0.0057), shear strain rate (P=0.0084), wall shear stress (WSS) (P=0.0085), and WSS gradient (P=0.0151) than blebs far from the inflow. In a subset of 12 ruptured aneurysms harboring blebs, rupture points were associated with thin blebs in 42% of aneurysms, atherosclerotic blebs in 25%, and were away from blebs in the remaining 33%.ConclusionsNot all blebs are equal; some have thin translucent walls while others have thick atherosclerotic walls. Thin blebs tend to be located closer to the inflow than atherosclerotic blebs. Blebs near the inflow are exposed to stronger flows with higher and spatially variable WSS than blebs far from the inflow which tend to have uniformly lower WSS. Aneurysms can rupture at thin blebs, atherosclerotic blebs, and even away from blebs. Further study of wall failure in aneurysms with different bleb types is needed.

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