Curcuma and Breast Cancer: A Focus on Cell Signaling Pathways

2021 ◽  
pp. 179-200
Author(s):  
Azhar Rasul ◽  
Ghulam Hussain ◽  
Ameer Fawad Zahoor ◽  
Ammara Riaz ◽  
Iqra Sarfraz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Cell Signaling Pathways

scholarly journals A Synthetic Triterpenoid CDDO-Im Inhibits Tumorsphere Formation by Regulating Stem Cell Signaling Pathways in Triple-Negative Breast Cancer

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107616 ◽  
Author(s):  
Jae Young So ◽  
Janice J. Lin ◽  
Joseph Wahler ◽  
Karen T. Liby ◽  
Michael B. Sporn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Signaling Pathways

Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways

2019 ◽  
Vol 27 (5) ◽  
pp. 1021-1036 ◽  
Author(s):  
Zhenjiang Zhao ◽  
Guoguo Jin ◽  
Yinghui Ge ◽  
Zhiping Guo
Keyword(s):  
Breast Cancer ◽  
Cell Signaling ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Breast Cancer Cells ◽  
Cell Signaling Pathways

scholarly journals Recent Advances in Targeting of Breast Cancer Stem Cells Based on Biological Concepts and Drug Delivery System Modification

2020 ◽  
Vol 10 (3) ◽  
pp. 338-349 ◽  
Author(s):  
Zeynab Aaliyari-Serej ◽  
Ayyub Ebrahimi ◽  
Balal Barazvan ◽  
Abbas Ebrahimi-Kalan ◽  
Khalil Hajiasgharzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Concepts ◽  
Cell Signaling Pathways

Breast cancer with various biological diversity known as the common reason of death in the world and despite progress in novel therapeutic approaches, it faced with failure and recurrence in general. Recent clinical and preclinical statistics support cancer stem cells (CSCs) hypothesis and its similarities with normal stem cells. Evaluation of related paper conclude in significance finding in the further characterization of CSCs biology such as surface biomarkers, microenvironment regulatory molecules, cell signaling pathways, cell to cell transition and drug efflux pumps to overcome multidrug resistance and effective therapy. Emerging novel data indicate biological concepts in the base of unsuccessful treatment. A powerful understanding of the cell signaling pathways in cancer and CSCs topics can be led us to define and control treatment problems in cancer. More recently nano medicine based on drug delivery system modification and new implications on combinatorial therapy have been used to treat breast cancer effectively. The aim of this review is focus on CSCs as a potential target of cancer therapy, to overcome the limitation and problems of current therapeutic strategies in cancer.

scholarly journals Impact of Stilbenes as Epigenetic Modulators of Breast Cancer Risk and Associated Biomarkers

2021 ◽  
Vol 22 (18) ◽  
pp. 10033
Author(s):  
Sebanti Ganguly ◽  
Itika Arora ◽  
Trygve O. Tollefsbol
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Cancer Susceptibility ◽  
Antioxidant Properties ◽  
Environment Interaction ◽  
Epigenetic Biomarkers ◽  
Cell Signaling Pathways

With the recent advancement of genetic screening for testing susceptibility to mammary oncogenesis in women, the relevance of the gene−environment interaction has become progressively apparent in the context of aberrant gene expressions. Fetal exposure to external stressors, hormones, and nutrients, along with the inherited genome, impact its traits, including cancer susceptibility. Currently, there is increasing interest in the role of epigenetic biomarkers such as genomic methylation signatures, plasma microRNAs, and alterations in cell-signaling pathways in the diagnosis and primary prevention of breast cancer, as well as its prognosis. Polyphenols like natural stilbenes have been shown to be effective in chemoprevention by exerting cytotoxic effects that can stall cell proliferation. Besides possessing antioxidant properties against the DNA-damaging effects of reactive oxygen species, stilbenes have also been observed to modulate cell-signaling pathways. With the increasing trend of early-life screening for hereditary breast cancer risks, the potency of different phytochemicals in harnessing the epigenetic biomarkers of breast cancer risk demand more investigation. This review will explore means of exploiting the abilities of stilbenes in altering the underlying factors that influence breast cancer risk, as well as the appearance of associated biomarkers.

Cell signaling pathways as molecular targets to eliminate AML stem cells

2021 ◽  
Vol 160 ◽  
pp. 103277
Author(s):  
Ana Carolina B. da C. Rodrigues ◽  
Rafaela G.A. Costa ◽  
Suellen L.R. Silva ◽  
Ingrid R.S.B. Dias ◽  
Rosane B. Dias ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Molecular Targets ◽  
Cell Signaling Pathways

scholarly journals Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

2021 ◽  
pp. 108634
Author(s):  
Ibrahim Jantan ◽  
Md. Areeful Haque ◽  
Laiba Arshad ◽  
Hemavathy Harikrishnan ◽  
Abdi Wira Septama ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Chronic Inflammation ◽  
Dietary Polyphenols ◽  
Cell Signaling Pathways
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