:
Since 1887, phenoxazine derivatives have attracted attention of chemist due to its versatile utility, industrially
and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives
like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, antidepressant, analgesic and many other drug resistance reversal activities. This review covers detailed over-view on
pharmacological application of phenoxazine nucleus, its chemistry and reactivity and also illustrating the incorporation of
different group at different positions enhancing its biological application, besides some synthetic procedures.