Medicinal and Biological Significance of Phenoxazine Derivatives

2020 ◽  
Vol 20 ◽  
Author(s):  
Jaya Dwivedi ◽  
Neetu Yaduvanshi ◽  
Shruti Shukla ◽  
Sonika Jain
Keyword(s):  
Drug Resistance ◽  
Biological Significance ◽  
Biological Application ◽  
Pharmacological Activities ◽  
Resistance Reversal ◽  
Anti Inflammatory ◽  
Pharmacological Application

: Since 1887, phenoxazine derivatives have attracted attention of chemist due to its versatile utility, industrially and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, antidepressant, analgesic and many other drug resistance reversal activities. This review covers detailed over-view on pharmacological application of phenoxazine nucleus, its chemistry and reactivity and also illustrating the incorporation of different group at different positions enhancing its biological application, besides some synthetic procedures.

Antimicrobial activities of various thiazine based heterocyclic compounds: A mini-review

2021 ◽  
Vol 18 ◽  
Author(s):  
Mohammad Asif ◽  
Mohd. Imran ◽  
Abida
Keyword(s):  
Antimicrobial Activity ◽  
Drug Resistance ◽  
Heterocyclic Compounds ◽  
Antimicrobial Agents ◽  
Antimicrobial Activities ◽  
Vital Role ◽  
Pharmacological Activities ◽  
Natural Sources ◽  
Anti Inflammatory ◽  
Heterocyclic Moiety

: Heterocyclic compounds play a vital role in the development of novel compounds due to their diverse pharmacological activities. Thiazine is a six-membered heterocyclic moiety. Various thiazine derivatives were synthesized or isolated from natural sources like plants and animals. Thiazine derivatives have varieties of pharmacological activities such as antimicrobial, antibacterial, antifungal, antiviral, anti-inflammatory, anticoagulant, anticancer, antihypertensive, and other useful biological as well as chemical applications. In the therapy of antimicrobial infections, new antimicrobial agents are needed because current antimicrobials have developed drug resistance. So, we discussed some thiazine derivatives which exhibited antimicrobial activity.

Recent Development of Sulfonyl or Sulfonamide Hybrids as Potential Anticancer Agents: A Key Review

2018 ◽  
Vol 18 (4) ◽  
pp. 488-505 ◽  
Author(s):  
K. P. Rakesh ◽  
Shi-Meng Wang ◽  
Jing Leng ◽  
L. Ravindar ◽  
Abdullah M. Asiri ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Anticancer Agents ◽  
Side Effect ◽  
Docking Studies ◽  
Multi Drug Resistance ◽  
Anticancer Activities ◽  
Pharmacological Activities ◽  
Synthetic Compounds ◽  
Structure Activity ◽  
Anticancer Drug Discovery

Cancer is the second leading cause of death worldwide. There is always a huge demand for novel anticancer drugs and diverse new natural or synthetic compounds are developed continuously by scientists. Presently, a large number of drugs in clinical practice have showed pervasive side effect and multidrug resistance. Sulfonyl or sulfonamide hybrids became one of the most attractive subjects due to their broad spectrum of pharmacological activities. Sulfonyl hybrids were broadly explored for their anticancer activities and it was found that they possess minimum side effect along with multi-drug resistance activity. This review describes the most recent applications of sulfonyl hybrid analogues in anticancer drug discovery and further discusses the mechanistic insights, structure-activity relationships and molecular docking studies for the potent derivatives.

scholarly journals Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3140
Author(s):  
Rocco Giordano ◽  
Zeinab Saii ◽  
Malthe Fredsgaard ◽  
Laura Sini Sofia Hulkko ◽  
Thomas Bouet Guldbæk Poulsen ◽  
...  
Keyword(s):  
Pain Relief ◽  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Medicinal Products ◽  
Salt Tolerant ◽  
Salicornia Europaea ◽  
Pharmacological Activities ◽  
Sustainable Resources ◽  
Anti Inflammatory ◽  
Significant Attention

The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species Aster tripolium, Crithmum maritimum and Salicornia europaea, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.

Polyprodrug with Glutathione Depletion and Cascade Drug Activation for Multi-drug Resistance Reversal

Biomaterials ◽  
2021 ◽  
pp. 120649
Author(s):  
Xuan Xiao ◽  
Kewei Wang ◽  
Qingyu Zong ◽  
Yalan Tu ◽  
Yansong Dong ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Glutathione Depletion ◽  
Multi Drug Resistance ◽  
Resistance Reversal ◽  
Drug Activation

Cisplatin Resistance Reversal of Lung Cancers by Tumor Acidity-Activable Vesicular Nanoreactors via Tumor Oxidative Stress Amplification

2021 ◽  
Author(s):  
Jean Felix Mukerabigwi ◽  
Yu Han ◽  
Nannan Lu ◽  
Wendong Ke ◽  
Yuheng Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Therapeutic Efficacy ◽  
Cisplatin Resistance ◽  
Clinical Applications ◽  
Lung Cancers ◽  
Resistance Reversal ◽  
Tumor Acidity ◽  
Stress Amplification ◽  
Novel Strategy

Drug resistance of cisplatin significantly limits its therapeutic efficacy in clinical applications against a variety of cancers. Herein, we develop a novel strategy to overcome cisplatin drug resistance through sensitizing...

Oxy+ (arthrospira) and its medicinal importance: an appraisal

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Md Anzar Alam ◽  
Mohd Aleemuddin Quamri ◽  
Muzafar Din Ahmad Bhat ◽  
Siddiqui Aafreen ◽  
Ghulamuddin Sofi
Keyword(s):  
Linoleic Acid ◽  
Dietary Supplement ◽  
Autoimmune Disorders ◽  
Natural Source ◽  
Sulfated Polysaccharides ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Anti Inflammatory ◽  
Obesity Hypertension

AbstractOxy+ is a natural source of arthrospira found in nature, used as a dietary supplement and manufactured in Aruba for lifefactors. Arthrospira contains good quality of proteins, sulfated polysaccharides, γ-linoleic acid, along with an array of carotene and phytopigments, vitamins, and minerals which are reported to be antioxidant, immunomodulator, antihyperglycemic, antidyslipidemic, cardioprotective, hepatoprotective, antiviral, anticancerous, antihypertensive, anti-inflammatory, analgesic, neuroprotective and renoprotective activities. Several studies have shown arthrospira, and active ingredients of it revealed various pharmacological activities. It can be used for the management of various ailments such as diabetes, dyslipidemia, obesity, hypertension, cancer, arthritis, osteoarthritis, autoimmune disorders, etc. This review attempts to explore the hidden benefits of Oxy+ (arthrospira).

Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2

2021 ◽  
Vol 21 ◽  
Author(s):  
Li Liu ◽  
Huiyun Wang ◽  
Xiaoyun Chai ◽  
Qingguo Meng ◽  
Sheng Jiang ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Pharmaceutical Preparation ◽  
Ginsenoside Rh2 ◽  
Red Ginseng ◽  
Antitumor Effects ◽  
Pharmacological Activities ◽  
Anti Inflammatory

: Ginsenoside Rh2 (3β-O-Glc-protopanaxadiol), a trace but characteristic pharmacological component of red ginseng, exhibited versatile pharmacological activities, such as antitumor effects, improved cardiac function and fibrosis, anti-inflammatory effects, antibiosis and excellent medicinal potential. In recent years, increased research has been performed on the biocatalytic synthesis of ginsenoside Rh2. In this paper, advances in the biocatalytic synthesis, pharmacological activities, pharmaceutical preparation and metabolism of ginsenoside Rh2 are reviewed.

The anti-inflammatory Design, Synthesis and Exploiting Pharmacological Activities of 2,3-Dihydrofuranocoumarins as Multi-Therapeutic Agents

2018 ◽  
Vol 3 (38) ◽  
pp. 10738-10749
Author(s):  
Jyoti M. Madar ◽  
Lokesh A. Shastri ◽  
Samundeeswari L. Shastri ◽  
Megharaja Holiyachi ◽  
Nirmala S. Naik ◽  
...  
Keyword(s):  
Therapeutic Agents ◽  
Pharmacological Activities ◽  
Design Synthesis ◽  
Anti Inflammatory
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