Clinical and Therapeutic Effectiveness of Nanoscale Antibacterial Drugs for Veterinary Use

The fight against staphylococcal infection, increasing the effectiveness of methods of prevention and treatment of diseases of staphylococcal etiology is of interest to scientists and practitioners, both in Ukraine and around the world. The urgency of this problem is growing rapidly, as there is a tendency to increase the resistance of not only staphylococci, but also other gram-positive bacteria. The spread of methicillin-resistant staphylococci restricts the choice of antibiotics for the treatment of diseases of staphylococcal etiology. Staphylococcus aureus is the most common and dangerous type, which is one of the main factors of purulent-inflammatory lesions of the skin and mucous membranes. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. One of the unique and promising medicinal plants, which contains a rich complex of biologically active substances (BAS), is common hops (Humulus lupulus L.). The complex of BAS (flavonoids, hormones, vitamins, bitter, phenolic compounds, essential oils) causes anti-inflammatory, bactericidal, hyposensitizing and analgesic action of hops. The purpose of this work is to determine the antistaphylococcal activity of the carbon dioxide extract of hops and to justify the development on its basis of new antimicrobial agents for the prevention and treatment of infectious and purulent-inflammatory diseases. The following methods were used: microbiological (method of diffusion into agar (well method)) and mathematical and statistical. The high antimicrobial activity of the carbon dioxide extract of hops has been established for museum test strains of the genus Staphylococcus. The results of the studies testify to the prospects of further study of the bactericidal properties of the extract of hops carbon dioxide with the aim of creating effective antimicrobial agents on its basis for the prevention and treatment of infectious and purulent-inflammatory diseases of staphylococcal etiology.

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Analysis on the practical situation of antibacterial drugs in ophthalmic cleaning surgery in our hospital

Frontiers of Clinical Medicine ◽

10.35534/fcm.0201002c ◽

2020 ◽

Vol 2 (1) ◽

pp. 6-9

Author(s):

Nan Jiang

Keyword(s):

Practical Situation ◽

Antibacterial Drugs

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Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

Current Medicinal Chemistry ◽

10.2174/0929867326666181220094229 ◽

2020 ◽

Vol 27 (1) ◽

pp. 154-169 ◽

Cited By ~ 7

Author(s):

Claudiu N. Lungu ◽

Bogdan Ionel Bratanovici ◽

Maria Mirabela Grigore ◽

Vasilichia Antoci ◽

Ionel I. Mangalagiu

Keyword(s):

Experimental Data ◽

Antimicrobial Properties ◽

Qsar Model ◽

Therapeutic Effectiveness ◽

Computational Results ◽

Pyridine Derivatives ◽

Quadruplex Dna ◽

Dna Intercalators ◽

Structure Activity ◽

G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

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Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00451.2019 ◽

2020 ◽

Vol 318 (5) ◽

pp. H1325-H1336

Author(s):

Jaime Eugenín ◽

Carolina Larraín ◽

Patricio Zapata

Keyword(s):

Carotid Body ◽

Therapeutic Use ◽

Therapeutic Effectiveness ◽

Sympathetic Outflow ◽

Sympathetic Hyperactivity ◽

Functional Changes ◽

Human Disorders ◽

Carotid Body Denervation

Unilateral carotid body denervation has been proposed as treatment for sympathetic hyperactivity-related human disorders. Its therapeutic effectiveness for maintaining a persistent decrease in the sympathetic outflow activity will depend on the absence of compensatory chemoreflex plasticity in the remnant carotid and aortic afferents. Here, we suggest that the integrity of central afferents after carotid body denervation is essential to prevent the emergence of plastic functional changes on the contralateral “intact” carotid nerve.

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Therapeutic effectiveness of an antibody against brevetoxin (PbTx-2)

Toxicon ◽

10.1016/0041-0101(89)90388-7 ◽

1989 ◽

Vol 27 (1) ◽

pp. 82

Keyword(s):

Therapeutic Effectiveness

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Clinical Study of 107 Hospitalized Patients with Peritonsillar Abscess

International Journal of Practical Otolaryngology ◽

10.1055/s-0041-1722857 ◽

2021 ◽

Vol 04 (01) ◽

pp. e11-e16

Author(s):

Risa Wakisaka ◽

Takumi Kumai ◽

Kan Kishibe ◽

Miki Takahara ◽

Akihiro Katada ◽

...

Keyword(s):

Clinical Study ◽

Initial Treatment ◽

Peritonsillar Abscess ◽

Laryngeal Edema ◽

Antibacterial Drugs ◽

Inferior Pole ◽

Duration Of Hospitalization ◽

The Right ◽

Superior Pole

AbstractWe conducted a retrospective analysis of the data of 107 cases of peritonsillar abscess treated at our hospital between January 2014 and December 2018. Data on age, sex, affected site, duration of hospitalization, method of drainage, presence/absence of laryngeal edema, antibacterial drugs used, and isolated bacteria were analyzed. Of the 107 patients, 71 were males and 36 were females; the median age was 44 years (range: 18–88 years).The left side was affected in 55 patients, the right side in 50 patients, and both sides in two patients. The abscess was localized in the superior pole in 71 patients, and in the inferior pole in 36 patients. Thirty-five patients had laryngeal edema, of which three underwent tracheotomy. Recurrence of the abscess was observed in 15 cases, with the recurrence developing within 3 months in 7 cases, and over a period of 3 years in 4 cases. As for the sensitivity of the causative bacteria to antibacterial drugs, 17% of the causative bacteria showed resistance to clindamycin, while none showed resistance to ampicillin/sulbactam (ABPC/SBT). We concluded that ABPC/SBT might be suitable for the initial treatment of peritonsillar abscess, and that we need to bear in mind the possibility of long-term recurrence.

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