Airways Smooth Muscle: Development, and Regulation of Contractility

1994 ◽  
Keyword(s):  
Smooth Muscle ◽  
Muscle Development ◽  
Airways Smooth Muscle

scholarly journals Molecular analysis of smooth muscle development in the mouse

1995 ◽  
Vol 204 (3) ◽  
pp. 278-290 ◽  
Author(s):  
Kirk M. McHugh
Keyword(s):  
Smooth Muscle ◽  
Molecular Analysis ◽  
Muscle Development

Myosin phosphatase isoform switching in vascular smooth muscle development

2006 ◽  
Vol 40 (2) ◽  
pp. 274-282 ◽  
Author(s):  
M PAYNE ◽  
H ZHANG ◽  
T PROSDOCIMO ◽  
K JOYCE ◽  
Y KOGA ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Development ◽  
Myosin Phosphatase ◽  
Isoform Switching

BMP4 and WNT signaling interact to promote mouse tracheal mesenchyme morphogenesis

2021 ◽  
Author(s):  
Natalia Bottasso Arias ◽  
Lauren Leesman ◽  
Kaulini Burra ◽  
John Snowball ◽  
Ronak M Shah ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Wnt Signaling ◽  
Rna Sequencing ◽  
Muscle Development ◽  
Target Genes ◽  
Bmp Signaling ◽  
Embryonic Mouse ◽  
Tracheal Cartilage ◽  
Cartilage Formation

Tracheobronchomalacia and Complete Tracheal Rings are congenital malformations of the trachea associated with morbidity and mortality for which the etiology remains poorly understood. Epithelial expression of Wls (a cargo receptor mediating Wnt ligand secretion) by tracheal cells is essential for patterning the embryonic mouse trachea's cartilage and muscle. RNA sequencing indicated that Wls differentially modulated the expression of BMP signaling molecules. We tested whether BMP signaling, induced by epithelial Wnt ligands, mediates cartilage formation. Deletion of Bmp4 from respiratory tract mesenchyme impaired tracheal cartilage formation that was replaced by ectopic smooth muscle, recapitulating the phenotype observed after epithelial deletion of Wls in the embryonic trachea. Ectopic muscle was caused in part by anomalous differentiation and proliferation of smooth muscle progenitors rather than tracheal cartilage progenitors. Mesenchymal deletion of Bmp4 impaired expression of Wnt/β-catenin target genes, including targets of WNTsignaling: Notum, and Axin2. In vitro, rBMP4 rescued the expression of Notum in Bmp4 deficient tracheal mesenchymal cells and induced Notum promoter activity via SMAD1/5. RNA sequencing of Bmp4 deficient tracheas identified genes essential for chondrogenesis and muscle development co-regulated by BMP and WNT signaling. During tracheal morphogenesis, WNT signaling induces Bmp4 in mesenchymal progenitors to promote cartilage differentiation and restrict trachealis muscle. In turn, Bmp4 differentially regulates the expression of Wnt/β-catenin targets to attenuate mesenchymal WNT signaling and to further support chondrogenesis.

G-Proteins in Airways Smooth Muscle

1994 ◽  
pp. 187-213
Author(s):  
Nigel J. Pyne ◽  
Susan Pyne
Keyword(s):  
Smooth Muscle ◽  
G Proteins ◽  
Airways Smooth Muscle
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