Electrical stimulation of the anterior cingulate cortex in a rat neuropathic pain model

2007 ◽  
pp. 65-71 ◽  
Author(s):  
S. I. Park ◽  
J. H. Oh ◽  
Y. S. Hwang ◽  
S. J. Kim ◽  
J. W. Chang
Keyword(s):  
Neuropathic Pain ◽  
Electrical Stimulation ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Pain Model ◽  
Neuropathic Pain Model ◽  
Stimulation Of

Mirth and laughter elicited by electrical stimulation of the human anterior cingulate cortex

Cortex ◽  
2015 ◽  
Vol 71 ◽  
pp. 323-331 ◽  
Author(s):  
Fausto Caruana ◽  
Pietro Avanzini ◽  
Francesca Gozzo ◽  
Stefano Francione ◽  
Francesco Cardinale ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Stimulation Of

scholarly journals Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts

2021 ◽  
Vol 12 ◽  
Author(s):  
Ashlyn Schmitgen ◽  
Jeremy Saal ◽  
Narayan Sankaran ◽  
Maansi Desai ◽  
Isabella Joseph ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Electrical Stimulation ◽  
Anterior Cingulate Cortex ◽  
Case Series ◽  
Cingulate Cortex ◽  
Brain Network ◽  
Anterior Cingulate ◽  
Functional Brain Network ◽  
Band Activity ◽  
Stimulation Of

The anterior cingulate cortex (ACC) has been extensively implicated in the functional brain network underlying chronic pain. Electrical stimulation of the ACC has been proposed as a therapy for refractory chronic pain, although, mechanisms of therapeutic action are still unclear. As stimulation of the ACC has been reported to produce many different behavioral and perceptual responses, this region likely plays a varied role in sensory and emotional integration as well as modulating internally generated perceptual states. In this case series, we report the emergence of subjective musical hallucinations (MH) after electrical stimulation of the ACC in two patients with refractory chronic pain. In an N-of-1 analysis from one patient, we identified neural activity (local field potentials) that distinguish MH from both the non-MH condition and during a task involving music listening. Music hallucinations were associated with reduced alpha band activity and increased gamma band activity in the ACC. Listening to similar music was associated with different changes in ACC alpha and gamma power, extending prior results that internally generated perceptual phenomena are supported by circuits in the ACC. We discuss these findings in the context of phantom perceptual phenomena and posit a framework whereby chronic pain may be interpreted as a persistent internally generated percept.

scholarly journals Long-Term Results of Deep Brain Stimulation of the Anterior Cingulate Cortex for Neuropathic Pain

2017 ◽  
Vol 106 ◽  
pp. 625-637 ◽  
Author(s):  
Sandra G.J. Boccard ◽  
Simon J. Prangnell ◽  
Laurie Pycroft ◽  
Binith Cheeran ◽  
Liz Moir ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Deep Brain Stimulation ◽  
Anterior Cingulate Cortex ◽  
Brain Stimulation ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Long Term Results ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Transcranial Ultrasound Stimulation of the Anterior Cingulate Cortex Reduces Neuropathic Pain in Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Xiangjun Feng ◽  
Lili Niu ◽  
Meng Long ◽  
Kaixuan Luo ◽  
Xiaowei Huang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Intervention Group ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Control Group ◽  
Mechanical Threshold ◽  
Stimulation Of

Focused ultrasound (FUS) is a potential tool for treating chronic pain by modulating the central nervous system. Herein, we aimed to determine whether transcranial FUS stimulation of the anterior cingulate cortex (ACC) effectively improved chronic pain in the chronic compress injury mice model at different stages of neuropathic pain. The mechanical threshold of pain was recorded in the nociceptive tests. We found FUS stimulation elevated the mechanical threshold of pain in both short-term ( p < 0.01 ) and long-term ( p < 0.05 ) experiments. Furthermore, we determined protein expression differences in ACC between the control group, the intervention group, and the Sham group to analyze the underlying mechanism of FUS stimulation in improving neuropathic pain. Additionally, the results showed FUS stimulation led to alterations in differential proteins in long-term experiments, including cellular processes, cellular signaling, and information storage and processing. Our findings indicate FUS may effectively alleviate mechanical neuropathic pain via the ACC’s stimulation, especially in the chronic state.

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