Plastidic ABC Proteins

2014 ◽  
pp. 103-136 ◽  
Author(s):  
Rebecca L. Roston ◽  
Anna K. Hurlock ◽  
Christoph Benning
Keyword(s):  
Abc Proteins

scholarly journals The repertoire of ABC proteins in Clostridioides difficile

2021 ◽  
Author(s):  
Methinee Pipatthana ◽  
Phurt Harnvoravongchai ◽  
Pisut Pongchaikul ◽  
Somsak Likhitrattanapisal ◽  
Matthew Phanchana ◽  
...  
Keyword(s):  
Abc Proteins ◽  
Clostridioides Difficile

Natural history of ABC systems: not only transporters

2011 ◽  
Vol 50 ◽  
pp. 19-42 ◽  
Author(s):  
Elie Dassa
Keyword(s):  
Common Ancestor ◽  
Three Dimensional ◽  
Last Common Ancestor ◽  
Abc Proteins ◽  
Hypothetical Scenario ◽  
History Of ◽  
Phylogenetic Perspective ◽  
Living Organisms

In recent years, our understanding of the functioning of ABC (ATP-binding cassette) systems has been boosted by the combination of biochemical and structural approaches. However, the origin and the distribution of ABC proteins among living organisms are difficult to understand in a phylogenetic perspective, because it is hard to discriminate orthology and paralogy, due to the existence of horizontal gene transfer. In this chapter, I present an update of the classification of ABC systems and discuss a hypothetical scenario of their evolution. The hypothetical presence of ABC ATPases in the last common ancestor of modern organisms is discussed, as well as the additional possibility that ABC systems might have been transmitted to eukaryotes, after the two endosymbiosis events that led to the constitution of eukaryotic organelles. I update the functional information of selected ABC systems and introduce new families of ABC proteins that have been included recently into this vast superfamily, thanks to the availability of high-resolution three-dimensional structures.

scholarly journals What monomeric nucleotide binding domains can teach us about dimeric ABC proteins

FEBS Letters ◽  
2020 ◽  
Vol 594 (23) ◽  
pp. 3857-3875
Author(s):  
Robert C. Ford ◽  
Ute A. Hellmich
Keyword(s):  
Nucleotide Binding ◽  
Abc Proteins ◽  
Binding Domains

INTRODUCTION TO BACTERIAL ABC PROTEINS

ABC Proteins ◽  
2003 ◽  
pp. 149-155 ◽  
Author(s):  
I. BARRY HOLLAND
Keyword(s):  
Abc Proteins

scholarly journals Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins

Structure ◽  
2018 ◽  
Vol 26 (9) ◽  
pp. 1259-1265.e3 ◽  
Author(s):  
Lu Qu ◽  
Yan Jiang ◽  
Chongyun Cheng ◽  
Dong Wu ◽  
Bing Meng ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Abc Proteins

scholarly journals Modulation of Leishmania ABC Protein Gene Expression through Life Stages and among Drug-Resistant Parasites

2006 ◽  
Vol 5 (10) ◽  
pp. 1713-1725 ◽  
Author(s):  
Philippe Leprohon ◽  
Danielle Légaré ◽  
Isabelle Girard ◽  
Barbara Papadopoulou ◽  
Marc Ouellette
Keyword(s):  
Gene Expression ◽  
Expression Profiling ◽  
Dna Microarrays ◽  
Leishmania Major ◽  
Complete Sequence ◽  
Life Stages ◽  
Data Set ◽  
Abc Proteins ◽  
Functional Studies ◽  
Abc Protein

ABSTRACT The ATP-binding cassette (ABC) protein superfamily is one of the largest evolutionarily conserved families and is found in all kingdoms of life. The recent completion of the Leishmania genome sequence allowed us to analyze and classify its encoded ABC proteins. The complete sequence predicts a data set of 42 open reading frames (ORFs) coding for proteins belonging to the ABC superfamily, with representative members of every major subfamily (from ABCA to ABCH) commonly found in eukaryotes. Comparative analysis showed that the same ABC data set is found between Leishmania major and Leishmania infantum and that some orthologues are found in the genome of the related parasites Trypanosoma brucei and Trypanosoma cruzi. Customized DNA microarrays were made to assess ABC gene expression profiling throughout the two main Leishmania life stages. Two ABC genes (ABCA3 and ABCG3) are preferentially expressed in the amastigote stage, whereas one ABC gene (ABCF3) is more abundantly expressed in promastigotes. Microarray-based expression profiling experiments also revealed that three ABC genes (ABCA3, ABCC3, and ABCH1) are overexpressed in two independent antimony-resistant strains compared to the parental sensitive strain. All microarray results were confirmed by real-time reverse transcription-PCR assays. The present study provides a thorough phylogenic classification of the Leishmania ABC proteins and sets the basis for further functional studies on this important class of proteins.

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