Numerical Modeling to Calculate Thermal Lesion Formation Using Internally-Cooled Electrodes during Radiofrequency Ablation of Liver Tumors

Author(s):  
Huang-Wen Huang
2017 ◽  
Vol 24 (3) ◽  
pp. 205-213 ◽  
Author(s):  
Franz G. M. Poch ◽  
Christian Rieder ◽  
Hanne Ballhausen ◽  
Verena Knappe ◽  
Jörg Peter Ritz ◽  
...  

Purpose. Radiofrequency ablation (RFA) for primary liver tumors and liver metastases is restricted by a limited ablation size. Multipolar RFA is a technical advancement of RFA, which is able to achieve larger ablations. The aim of this ex vivo study was to determine optimal ablation parameters for multipolar RFA depending on applicator distance and energy input. Methods. RFA was carried out ex vivo in porcine livers with three internally cooled, bipolar applicators in multipolar ablation mode. Three different applicator distances were used and five different energy inputs were examined. Ablation zones were sliced along the cross-sectional area at the largest ablation diameter, orthogonally to the applicators. These slices were digitally measured and analyzed. Results. Sixty RFA were carried out. A limited growth of ablation area was seen in all test series. This increase was dependent on ablation time, but not on applicator distance. A steady state between energy input and energy loss was not observed. A saturation of the minimum radius of the ablation zone was reached. Differences in ablation radius between the three test series were seen for lowest and highest energy input ( P < .05). No differences were seen for medium amounts of energy ( P > .05). Conclusions. The ablation parameters applicator distance and energy input can be chosen in such a way, that minor deviations of the preplanned ablation parameters have no influence on the size of the ablation area.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
F. G. M. Poch ◽  
C. A. Neizert ◽  
B. Geyer ◽  
O. Gemeinhardt ◽  
S. M. Niehues ◽  
...  

AbstractMultibipolar radiofrequency ablation (RFA) is an advanced ablation technique for early stage hepatocellular carcinoma and liver metastases. Vessel cooling in multibipolar RFA has not been systematically investigated. The objective of this study was to evaluate the presence of perivascular vital cells within the ablation zone after multibipolar RFA. Multibipolar RFA were performed in domestic pigs in vivo. Three internally cooled bipolar RFA applicators were used simultaneously. Three experimental settings were planned: (1) inter-applicator-distance: 15 mm; (2) inter-applicator-distance: 20 mm; (3) inter-applicator-distance: 20 mm with hepatic inflow occlusion (Pringle maneuver). A vitality staining was used to analyze liver cell vitality around all vessels in the ablation center with a diameter > 0.5 mm histologically. 771 vessels were identified. No vital tissue was seen around 423 out of 429 vessels (98.6%) situated within the central white zone. Vital cells could be observed around major hepatic vessels situated adjacent to the ablation center. Vessel diameter (> 3.0 mm; p < 0.05) and low vessel-to-ablation-center distance (< 0.2 mm; p < 0.05) were identified as risk factors for incomplete ablation adjacent to hepatic vessels. The vast majority of vessels, which were localized in the clinically relevant white zone, showed no vital perivascular cells, regardless of vessel diameter and vessel type. However, there was a risk of incomplete ablation around major hepatic vessels situated directly within the ablation center. A Pringle maneuver could avoid incomplete ablations.


2004 ◽  
Vol 15 (11) ◽  
pp. 1323-1327 ◽  
Author(s):  
Toyomichi Shibata ◽  
Toshiya Shibata ◽  
Yoji Maetani ◽  
Takeshi Kubo ◽  
Kyo Itoh ◽  
...  

Author(s):  
Pierre C. Qian ◽  
Duc Minh Nguyen ◽  
Michael Anthony Barry ◽  
Vu Tran ◽  
Juntang Lu ◽  
...  

2012 ◽  
Vol 47 (3) ◽  
pp. e7-e12 ◽  
Author(s):  
Stijn van Laarhoven ◽  
Robertine van Baren ◽  
Rienk Yde Johan Tamminga ◽  
Koert Pieter de Jong

2021 ◽  
Author(s):  
Peizhao Yu ◽  
Tianyu Fu ◽  
Chan Wu ◽  
Yurong Jiang ◽  
Jian Yang

2009 ◽  
Vol 20 (7) ◽  
pp. S342-S347 ◽  
Author(s):  
Debra A. Gervais ◽  
S. Nahum Goldberg ◽  
Daniel B. Brown ◽  
Michael C. Soulen ◽  
Steven F. Millward ◽  
...  

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